First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

Nature Biomedical Engineering, Journal Year: 2019, Volume and Issue: 4(3), P. 259 - 271

Published: Dec. 23, 2019

Language: Английский

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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

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Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(30), P. 16294 - 16308

Published: Aug. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Language: Английский

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Multimodal Biophotonics of Semiconducting Polymer Nanoparticles

Accounts of Chemical Research, Journal Year: 2018, Volume and Issue: 51(8), P. 1840 - 1849

Published: Aug. 3, 2018

ConspectusBiophotonics as an interdisciplinary frontier plays increasingly important role in modern biomedical science. Optical agents are generally involved biophotonics to interpret biomolecular events into readable optical signals for imaging and diagnosis or convert photons other forms of energy (such heat, mechanical force, chemical radicals) therapeutic intervention biological stimulation. Development new including metallic nanoparticles, quantum dots, up-conversion carbon silica nanoparticles has contributed the advancement this field. However, most these have their own merits demerits, making them less effective multimodal biophotonic platforms.In Account, we summarize our recent work on development near-infrared (NIR) semiconducting polymer (SPNs) light converters advanced biophotonics. SPNs composed π-electron delocalized polymers (SPs) often possess advantages good biocompatibility, high photostability, large absorption coefficients. Because photophysical properties mainly determined by molecular structures precursor polymers, engineering allows us fine tune processes obtain different responses, even second NIR window (1000–1700 nm). Meanwhile, facile nanoformulation methods enable alteration outer inner diverse interactions.The unique brought about ultrasensitive deep-tissue imaging. NIR-absorbing with strong charge-transfer backbones can photoenergy acoustic waves, permitting photoacoustic that bypasses issue scattering reaches centimeter tissue penetration depth. Differently, phenylenevinylene-containing store photon via defects emit long-NIR afterglow luminescence a half-life ∼6 min after cessation excitation. Such process avoids autofluorescence, giving rise ultrahigh signal-to-background ratios. So far, SPN-based probes been developed image disease tissues (tumors), biomarkers (biothiols reactive oxygen species), physiological indexes (pH temperature) preclinical animal models.The synthetic flexibility further permits light-modulated interventions. Till now, photothermal conversion efficiencies shaped transducers remotely regulate protein ion channels, enzymatic activity, gene expression. In conjunction desired biodistribution tumor-homing ability, doped coated inorganic amplified self-regulated photodynamic cancer therapy.This Account thus demonstrates serve nanoplatform provide unprecedented opportunities imaging, noninvasive bioactivation, therapy.

Language: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 9, 2020

Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at morphological levels. An dye emitting up 1600 nm quantum yield 11.5% NIR-II region is developed. fluorescence blood vessels deeply-located intestinal tract live mice based on dyes achieved high clarity enhanced signal-to-background ratio. We hope this study will inspire further development evolution bio-imaging.

Language: Английский

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Supramolecular cancer nanotheranostics

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(4), P. 2839 - 2891

Published: Jan. 1, 2021

Supramolecular cancer nanotheranostics have shown promising potentials in early-stage diagnosis and personal therapy. Herein, we summarize the progress of supramolecular provide guidance for designing new targeted theranostic agents.

Language: Английский

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All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(31)

Published: May 23, 2019

Abstract Development of single near‐infrared (NIR) laser triggered phototheranostics for multimodal imaging guided combination therapy is highly desirable but still a big challenge. Herein, novel small‐molecule dye DPP‐BT designed and synthesized, which shows strong absorption in the first NIR window (NIR‐I) fluorescence emission second region (NIR‐II). Such not only acts as dual‐modal contrast agent NIR‐II photoacoustic (PA) imaging, also serves combined therapeutic photothermal (PTT) photodynamic (PDT). The all‐in‐one phototheranostic nanoparticles are constructed by encapsulating DPP‐BT, chemotherapy drug DOX, natural phase‐change materials with folic acid functionalized amphiphile. Notably, under irradiation, DOX can effectively release from such via NIR‐induced hyperthermia DPP‐BT. By intravenous injection into Hela tumor‐bearing mice, tumor size location be accurately observed fluorescence/PA imaging. From vitro vivo results, simultaneously present remarkable antitumor efficacy PTT/PDT/chemo therapy, laser. Overall, this work provides an innovative strategy to design construct nanoplatforms clinical phototheranostics.

Language: Английский

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Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(11)

Published: Jan. 21, 2019

Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1700 nm) holds great promise for deep-tissue diagnosis due to reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive technique is greatly constrained by lack biodegradable NIR-II absorbing agents. Herein, first series metabolizable PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist π-conjugated yet oxidizable optical as generator hydrolyzable amphiphilic particle matrix provide water solubility. The obtained SPNs readily degraded myeloperoxidase lipase abundant phagocytes, transforming from nonfluorescent (30 into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these can be effectively cleared out via both hepatobiliary renal excretions after systematic administration, leaving no toxicity living mice. Particularly possess high photothermal conversion efficiencies emit bright signals at 1064 nm, enabling sensitive subcutaneous tumor deep brain vasculature through intact skull animals low dosage. This study thus provides generalized molecular design toward materials biophotonic applications window.

Language: Английский

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X-ray-activated nanosystems for theranostic applications

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 3073 - 3101

Published: Jan. 1, 2019

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of cancer treatment leads to insufficient radiation energy deposition due low X-ray attenuation coefficients living tissues organs, producing unavoidable excessive doses with serious side effects healthy body parts. Over past decade, developments materials science nanotechnology have led rapid progress field X-ray-activated tumor-targeting nanosystems, which able tackle even systemic tumors relieve burden exposure large doses. Additionally, novel imaging contrast agents techniques also been developed. In comparison conventional external light sources (e.g., near infrared), technique is ideal activation nanosystems applications its nearly unlimited penetration depth organisms. this review, we systematically describe interaction mechanisms between provide an overview X-ray-sensitive recent on cancer-associated theranostic applications.

Language: Английский

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