Microbe-material hybrids for therapeutic applications DOI
Meng Chen, Lili Xia, Chenyao Wu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(16), P. 8306 - 8378

Published: Jan. 1, 2024

As natural living substances, microorganisms have emerged as useful resources in medicine for creating microbe-material hybrids ranging from nano to macro dimensions. The engineering of microbe-involved nanomedicine capitalizes on the distinctive physiological attributes microbes, particularly their intrinsic "living" properties such hypoxia tendency and oxygen production capabilities. Exploiting these remarkable characteristics combination with other functional materials or molecules enables synergistic enhancements that hold tremendous promise improved drug delivery, site-specific therapy, enhanced monitoring treatment outcomes, presenting substantial opportunities amplifying efficacy disease treatments. This comprehensive review outlines microbial derivatives used biomedicine specific advantages therapeutic application. In addition, we delineate fundamental strategies mechanisms employed constructing hybrids. diverse biomedical applications constructed hybrids, encompassing bioimaging, anti-tumor, anti-bacteria, anti-inflammation diseases therapy are exhaustively illustrated. We also discuss current challenges prospects associated clinical translation hybrid platforms. Therefore, unique versatility potential exhibited by position them promising candidates development next-generation biomaterials theranostic functionalities.

Language: Английский

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment DOI
Rui Liu, Cong Luo, Zhiqing Pang

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

Citations

360
Bioengineered nanogels for cancer immunotherapy DOI

Xianbin Ma,

Shu‐Jin Li, Yuantong Liu

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 5136 - 5174

Published: Jan. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Language: Английский

Citations

136
Biomedical polymers: synthesis, properties, and applications DOI Open Access
Wei‐Hai Chen, Qi‐Wen Chen, Qian Chen

et al.

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

Citations

134
Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field DOI Creative Commons
Xiaotu Ma, Xiaolong Liang, Yao Li

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 23, 2023

Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression drug release should be spatiotemporally controlled to avoid in healthy tissues undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating orthotopic colon tumors female mice, the paramagnetic nanoparticles enable receive convert signals into heat, thereby initiating of lysis proteins under control a heat-sensitive promoter. then lyse, releasing its anti-CD47 nanobody cargo, that is pre-expressed within bacteria. robust immunogenicity lysate cooperates activate both innate adaptive immune responses, generating antitumor effects against not only but also distal mice. magnetically constant field-controlled motion enhanced targeting increased therapeutic efficacy. Thus, behavior can manipulated vivo field, achieving tumor-specific CD47 blockage precision immunotherapy.

Language: Английский

Citations

127
Progress of engineered bacteria for tumor therapy DOI
Jin‐Xuan Fan,

Mei‐Ting Niu,

You‐Teng Qin

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114296 - 114296

Published: April 16, 2022

Language: Английский

Citations

78
Engineered Living Materials for Advanced Diseases Therapy DOI Open Access
Dong Xue, Wei Wu, Pei Pan

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

Citations

56
Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer DOI Creative Commons

Yueyue Fan,

Jiamin Ye, Yong Kang

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(19)

Published: May 8, 2024

Lactic acid (LA) accumulation in the tumor microenvironment poses notable challenges to effective immunotherapy. Here, an intelligent treatment microrobot based on unique physiological structure and metabolic characteristics of

Language: Английский

Citations

43
Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy DOI
Wenfei Chen, Yining Zhu,

Zhirong Zhang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114295 - 114295

Published: April 13, 2022

Language: Английский

Citations

44
Chemically engineering cells for precision medicine DOI
Yixin Wang, Zhaoting Li,

Fanyi Mo

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 1068 - 1102

Published: Jan. 1, 2023

This review summarizes chemical tools for cell engineering, introduces their wide application in diagnosis and therapy, discusses the challenges opportunities precision medicine.

Language: Английский

Citations

42
Nano Proteolysis Targeting Chimeras (PROTACs) with Anti‐Hook Effect for Tumor Therapy DOI

Ni‐Yuan Zhang,

Da‐Yong Hou, Xingjie Hu

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(37)

Published: July 24, 2023

Abstract Proteolysis targeting chimera (PROTAC) is an emerging pharmacological modality with innovated post‐translational protein degradation capabilities. However, off‐target induced unintended tissue effects and intrinsic “hook effect” hinder PROTAC biotechnology to be maturely developed. Herein, intracellular fabricated nano proteolysis chimeras (Nano‐PROTACs) a center‐spoke network for achieving efficient dose‐dependent in tumor reported. The precursors are triggered by higher GSH concentrations inside cells, which subsequently situ self‐assemble into Nano‐PROTACs through intermolecular hydrogen bond interactions. fibrous can form effective polynary complexes E3 ligases multi‐binding sites, “anti‐hook effect”. generality efficacy of validated degrading variable interest (POI) such as epidermal growth factor receptor (EGFR) androgen (AR) wide‐range manner 95 % rate long‐lasting potency up 72 h vitro. Significantly, achieve vivo 79 inhibition A549 LNCap xenograft mice models, respectively. Taking advantages self‐assembly strategy, the provide generalizable platform promote precise clinical translational application PROTAC.

Language: Английский

Citations

41