Artificial Polymerizations in Living Organisms for Biomedical Applications DOI
Yun Chen,

Brynne Shu Ni Tan,

Yu Cheng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract Within living organisms, numerous nanomachines are constantly involved in complex polymerization processes, generating a diverse array of biomacromolecules for maintaining biological activities. Transporting artificial polymerizations from lab settings into contexts has expanded opportunities understanding and managing events, creating novel cellular compartments, introducing new functionalities. This review summarizes the recent advancements polymerizations, including those responding to external stimuli, internal environmental factors, that polymerize spontaneously. More importantly, cutting‐edge biomedical application scenarios polymerization, notably safeguarding cells, modulating improving diagnostic performance, facilitating therapeutic efficacy highlighted. Finally, this outlines key challenges technological obstacles remain as well offers insights potential directions advancing their practical applications clinical trials.

Language: Английский

Engineered Living Materials for Advanced Diseases Therapy DOI Open Access
Dong Xue, Wei Wu, Pei Pan

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

Citations

56
Progress in ATRP-derived materials for biomedical applications DOI Creative Commons
Mohsen Khodadadi Yazdi,

Payam Zarrintaj,

Mohammad Reza Saeb

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 143, P. 101248 - 101248

Published: Feb. 11, 2024

Language: Английский

Citations

19
Atom transfer radical polymerization DOI
Simon Harrisson, Richard Whitfield, Athina Anastasaki

et al.

Nature Reviews Methods Primers, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 9, 2025

Language: Английский

Citations

5
DNA-Based Hydrogels for Bone Regeneration: A Promising Tool for Bone Organoids DOI Creative Commons
Xiang Wu, Yan Hu, Shihao Sheng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101502 - 101502

Published: Jan. 19, 2025

DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These facilitate the formation of spatial structures through bulk hydrogel fabricating, microsphere formatting, 3D printing. Furthermore, microenvironment can be finely tuned by leveraging degradation products, nanostructure, targeting, delivery capabilities inherent materials. In this review, we underscore advantages hydrogels, detailing composition, gelation techniques, structure optimization. We then delineate three critical elements in promotion using hydrogels: (i) osteogenesis driven phosphate ions, plasmids, oligodeoxynucleotides (ODNs) that enhance mineralization promote gene protein expression; (ii) vascularization facilitated tetrahedral DNA nanostructures (TDNs) aptamers, which boosts expression targeted release; (iii) immunomodulation achieved loaded factors, TDNs, bound ions stimulate macrophage polarization exhibit antibacterial properties. With these properties, used construct organoids, providing an innovative tool disease modeling therapeutic applications tissue engineering. Finally, discuss current challenges future prospects, emphasizing potential impacts regenerative medicine.

Language: Английский

Citations

5
Synthesizing biomaterials in living organisms DOI
Xiangyang Zhang, Junxia Wang, Ying Zhang

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(23), P. 8126 - 8164

Published: Jan. 1, 2023

Synthesizing biomaterials from building blocks in living organisms.

Language: Английский

Citations

32
Light-mediated intracellular polymerization DOI
Mohamed Abdelrahim, Quan Gao, Yichuan Zhang

et al.

Nature Protocols, Journal Year: 2024, Volume and Issue: 19(7), P. 1984 - 2025

Published: March 21, 2024

Language: Английский

Citations

11
Artificial Cell Wall: From Maintenance of Cell Viability to Boosting New Cellular Functionalities† DOI Open Access
Haoxiang Yuan, Xin Qiao, Shangsong Li

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Comprehensive Summary Artificial cell wall (ACW) referring to active functional cellular nano‐coatings is capable of providing more cell‐shell synergic and cooperative properties than conventional single nanoencapsulation (SCNE). With the development SCNE, issues cytocompatibility, degradability, etc ., have already been improved successively. However, further emphasis on cooperativity between itself its shell still missing paying attention functions hybrids. Recent research proved that construction nano‐coating cells not only needs satisfy functionalization cells, but also necessary empower interact with other environments. This indicates SCNEs are tending be “active” participate in metabolic process gradually develop stage ACWs. review provided a reasonable description artificial wall, realization this concept requires cooperativity, self‐adaption fluxionality. Then, methodologies constructing ACWs were discussed. Finally, applications summarized accompanied by potential outlook given fields. Key Scientists Within recent ten years, fabricating biocompatible surface for cyto‐protection rapidly developed. For example, Rawil F. Fakhrullin Yuri M. Lvov developed ‘layer‐by‐layer’ strategy construct ‘face‐lifting’ micro‐organisms. Afterwards, Choi introduced ‘artificial spore’ which thin tough encapsulations. At same time, Tsukruk hydrogel‐based terms 2013. In 2016, Tang reported biomimetic mineralization can used improve modify metabolism processes cells. More advanced, Qu Hawker separately way introduce manganese dioxide nanozymes in‐situ ‐grafting polymers realize responsive effects towards regulation 2017. 2018, Huang showed generate type heritable based situ self‐assembly coacervate micro‐droplets around yeast 2019, Jeffrey nanoparticles adopted exoskeletons outside endow new forming ‘supracells’. put forward concepts ‘active shell’ ‘dynamic indicated nanoencapsulations was beginning transition control fate degradable walls 2020 an intracellular method regulate algae promote hydrogen production. Based his previous research, focused introducing fabrication wall’.

Language: Английский

Citations

2
Frontier applications of retinal nanomedicine: progress, challenges and perspectives DOI Creative Commons

Zhimin Tang,

Fuxiang Ye, Ni Ni

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.

Language: Английский

Citations

2
Extracellular DNA as potential contributors to pathological calcification DOI Creative Commons

Long-zhang Niu,

Yi‐na Zhu,

Mei‐chen Wan

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)

Published: March 5, 2024

Abstract Some biomolecules involved in pathological calcification have been identified. However, the exact mechanism which this intricate process occurs remains unknown. Extracellular DNA (exDNA) has recently recognized as a partaker ectopic phenomenon. acts an intercellular messenger that transmits information and orchestrates complex inflammatory responses. Changes morphology or function of exDNA may trigger under conditions. In present review, recent advances on how is released into extracellular milieu to become will be highlighted conjunction with directly indirectly contributes progression calcification. Emphasis placed “gluing” effect neutrophil traps act bridge between inflammation Manipulation open new vistas for development enterprising strategies prevent treat

Language: Английский

Citations

7
Chemiluminescence Resonance Energy Transfer for Targeted Photoactivation of Ion Channels in Living Cells DOI Open Access
Gang Song, Zhiwen Yang,

Junjie Cheng

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate stress-sensitive membrane channels situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on conjugated oligomer, oligo(p-phenylenevinylene)-imidazolium (OPV-Im), designed the activation transient receptor potential melastatin 2 (TRPM2) calcium by superoxide anion (O2⋅-) without requiring external light sources. OPV-Im oligomer targeted cell efficiently, leading TRPM2 CRET process subsequent intracellular overload. This cascade resulted mitochondrial damage inhibition autophagy, ultimately inducing apoptosis. Additionally, strategy could be applied selective killing tumor that overexpress ion inhibiting growth three-dimensional (3D) spheroids. Our offers novel approach regulating channel activity compared optogenetics photodynamic therapy.

Language: Английский

Citations

1