ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(4), P. 1061 - 1082
Published: March 8, 2023
Due
to
their
precise
three-dimensional
structures
and
tunable
cavities,
metallacages
covalent
cages
have
been
widely
used
in
various
fields,
such
as
catalysis,
separation,
sensing,
biomedicine.
As
a
result
of
the
unique
pattern
directed
synthesis
modular
assembly,
can
be
modified
many
different
ways
construct
stimuli-responsive
for
marker
detection
imaging
biological
applications.
Additionally,
agents
drugs
loaded
into
cavity
achieve
disease
diagnosis
treatment.
This
Review
summarizes
recent
advances
applications
presents
representative
examples
therapeutics.
The
problems
future
development
directions
are
emphasized,
which
may
provide
clear
guidance
design
application
controllable
diagnostic
reagents.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(7), P. 4021 - 4078
Published: March 22, 2024
Fluorescence
imaging
is
one
of
the
most
promising
approaches
to
achieve
intraoperative
assessment
tumor/normal
tissue
margins
during
cancer
surgery.
This
critical
improve
patients'
prognosis,
and
therefore
various
molecular
fluorescence
probes
have
been
developed
for
identification
lesions
Among
them,
"activatable"
that
react
with
cancer-specific
biomarker
enzymes
generate
signals
great
potential
high-contrast
due
their
low
background
high
signal
amplification
by
enzymatic
turnover.
Over
past
two
decades,
activatable
employing
control
mechanisms
worldwide
this
purpose.
Furthermore,
new
activities
specific
types
cancers
identified,
enabling
visualization
sensitivity
specificity.
Review
focuses
on
recent
advances
in
design,
function
characteristics
target
also
discusses
future
prospects
field
activity-based
diagnostics
cancer.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(18), P. 12656 - 12663
Published: April 29, 2024
Tumor-associated
mast
cells
(TAMCs)
have
been
recently
revealed
to
play
a
multifaceted
role
in
the
tumor
microenvironment.
Noninvasive
optical
imaging
of
TAMCs
is
thus
highly
desired
gain
insights
into
their
functions
cancer
immunotherapy.
However,
due
lack
single
enzyme
that
specific
cells,
common
probe
design
approach
based
on
single-enzyme
activation
not
applicable.
Herein,
we
reported
bienzyme-locked
molecular
(THCMC)
photoinduced
electron
transfer-intramolecular
charge-transfer
hybrid
strategy
for
vivo
TAMCs.
The
mechanism
ensures
THCMC
exclusively
turns
near-infrared
(NIR)
fluorescence
only
presence
both
tryptase
and
chymase
specifically
coexpressed
by
cells.
Thus,
effectively
distinguishes
from
other
leukocytes,
including
T
neutrophils,
macrophages,
capability
lacking
single-locked
probes.
Such
high
specificity
allows
noninvasive
tracking
fluctuation
living
mice
during
results
reveal
decreased
intratumoral
signal
after
combination
immunotherapy
correlates
well
with
reduced
population
TAMCs,
accurately
predicting
inhibition
growth.
this
study
presents
first
NIR
fluorescent
but
also
proposes
generic
cell
imaging.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 7, 2024
Abstract
Conjugated
polymers
(CPs)
have
promising
applications
in
biomedical
fields,
such
as
disease
monitoring,
real‐time
imaging
diagnosis,
and
treatment.
As
a
luminescent
material
with
tunable
emission,
high
brightness
excellent
stability,
CPs
are
widely
used
fluorescent
probes
biological
detection
imaging.
Rational
molecular
design
structural
optimization
broadened
absorption/emission
range
of
CPs,
which
more
conductive
for
diagnosis
precision
therapy.
This
review
provides
comprehensive
overview
recent
advances
the
application
aiming
to
elucidate
their
functional
relationships.
The
fluorescence
properties
mechanism
signal
amplification
first
discussed,
followed
by
an
elucidation
emerging
detection.
Subsequently,
CPs‐based
systems
therapeutic
strategies
illustrated
systematically.
Finally,
advancements
utilizing
electroactive
materials
bioelectronic
devices
also
investigated.
Moreover,
challenges
outlooks
medicine
discussed.
Through
this
systematic
review,
it
is
hoped
highlight
frontier
progress
promote
new
breakthroughs
fundamental
research
clinical
transformation.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 5, 2024
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
is
burgeoning
because
of
its
higher
fidelity
monitoring
physiological
and
pathological
processes
than
clinical
visible/the
fluorescence
imaging.
Notably,
heavily
dependent
on
agents.
So
far,
indocyanine
green,
one
polymethine
dyes,
with
good
biocompatibility
renal
clearance
only
dye
approved
by
Food
Drug
Administration,
but
it
shows
relatively
low
NIR-II
brightness.
Importantly,
tremendous
efforts
are
devoted
to
synthesizing
dyes
for
preclinically
clinically.
They
have
shown
feasibility
customization
structure
properties
fulfill
various
needs
therapy.
Herein,
a
timely
update
special
focus
molecular
design
strategies
fluorescent,
photoacoustic,
multimodal
imaging,
offered.
Furthermore,
progress
sensing
biomarkers
even
reporting
drug
release
illustrated.
Moreover,
imaging-guided
therapies
summarized
regarding
chemo-,
photothermal,
photodynamic,
approaches.
In
addition,
artificial
intelligence
pointed
out
potential
expedite
development.
This
comprehensive
review
will
inspire
interest
among
wide
audience
offer
handbook
people
an
dyes.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(32)
Published: March 22, 2024
Abstract
The
development
of
semiconducting
polymers
(SPs)
with
simultaneous
second
near‐infrared
(NIR‐II)
absorption
and
multimodal
phototheranostic
functions
is
highly
desired
in
the
field
oncotherapy.
Aggregation‐induced
emission
luminogens
(AIEgens)
have
been
acknowledged
to
possess
unique
potential
integrating
multiple
diagnostic
therapeutic
modalities
into
one
organic
molecule.
Nevertheless,
SPs
are
hard
achieve
AIE
activity
due
their
extended
π‐conjugated
skeletons
as
well
large
planar
configuration
commonly‐used
electrophilic
acceptor
moieties.
Herein,
an
ingenious
dimerization‐based
distortion
strategy
proposed
current
work
by
taking
advantage
sterically
encumbered
acceptors
structure
for
successful
construction
AIE‐active
SPs.
Through
further
finely
adjusting
molecular
donor–acceptor
interaction
strength,
obtained
named
SP3
bearing
highest
intramolecular
charge
transfer
effect
presented
NIR‐II
aggregation‐induced
fluorescence
emission,
good
reactive
oxygen
species
production
ability,
superior
photothermal
conversion
performance.
Accordingly,
selected
fabricate
nanoparticles
successfully
applied
laser‐triggered
fluorescence‐photoacoustic
imaging‐guided
photodynamic‐photothermal
therapy
tumors.
This
study
represents
first
excitable
SP,
offers
a
new
perspective
on
designing
advanced
efficient
treatment
malignant
tumor.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(32)
Published: May 23, 2024
Clear
delineation
of
tumor
margins
is
essential
for
accurate
resection
and
decreased
recurrence
rate
in
the
clinic.
Fluorescence
imaging
emerging
as
a
promising
alternative
to
traditional
visual
inspection
by
surgeons
intraoperative
imaging.
However,
probes
lack
accuracy
diagnosis,
making
it
difficult
depict
boundaries
accurately.
Herein,
we
proposed
an
offensive
defensive
integration
(ODI)
strategy
based
on
"attack
systems
(invasive
peptidase)
defense
(reductive
microenvironment)"
multi-dimensional
characteristics
design
activatable
fluorescent
precisely.
Screened
out
from
series
ODI
strategy-based
probes,
ANQ
performed
better
than
unilateral
correlation
distinguishing
between
cells
normal
minimizing
false-positive
signals
living
metabolic
organs.
To
further
improve
signal-to-background
ratio
vivo,
derivatized
FANQ,
was
prepared
successfully
applied
distinguish
orthotopic
hepatocellular
carcinoma
tissues
adjacent
mice
models
clinical
samples.
This
work
highlights
innovative
develop
rapid
diagnosis
tumors
high-precision
boundaries,
providing
more
efficient
tools
future
applications
assisted
resection.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
