Hydration Activates Dual‐Confined Shape‐Memory Effects of Cold‐Reprogrammable Photonic Crystals DOI
Yong Qi, Liujun Song,

Changtong Zhou

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(16)

Published: Jan. 20, 2023

Shape-memory photonic crystals (SMPCs) transform the nanoscale deformation of copolymers into structural color through an undifferentiated response to stimuli; however, activatable selective responses are extremely rare. Herein, dual confined shape-memory effects (CSMEs) derived from remodeling interchain hydrogen bonds (H-bonds) in cold-programmable SMPCs revealed. The first level is water-triggered reconstruction H-bonds, which can activate/lock collapsed skeleton, showing shape recovery/retention ethanol vapor. second pressure-induced reorganization H-bonds that results recovered skeleton being locked even when exposed vapor or water, while background porous structure switch between collapse and recovery. Dual CSMEs result Laplace pressure difference binding effect according insights swelling, situ tracking, multidimensional infrared spectra, water wetting/evaporation simulations. signal interference, source code extraction, enhancement structurally colored patterns be implemented using CSMEs. This work opens up a new method for fabricating responsive contributes expansion nanophotonic technology printing, erasable watermarks, amplifiers, information coding.

Language: Английский

Aggregation-Induced Emission (AIE), Life and Health DOI Creative Commons
Haoran Wang, Qiyao Li, Parvej Alam

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

Citations

189
Multicharged cyclodextrin supramolecular assemblies DOI
Zhixue Liu, Yu Liu

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(11), P. 4786 - 4827

Published: Jan. 1, 2022

Multicharged cyclodextrin (CD) supramolecular assemblies, including those based on positively/negatively charged modified mono-6-deoxy-CDs, per-6-deoxy-CDs, and random 2,3,6-deoxy-CDs, as well parent CDs binding guests, have been extensively applied in chemistry, materials science, medicine, biological catalysis, other fields. In this review, we primarily focus summarizing the recent advances encapsulating especially construction process of assemblies their applications. Compared with uncharged CDs, multicharged display remarkably high antiviral antibacterial activity efficient protein fibrosis inhibition. Meanwhile, can interact oppositely dyes, drugs, polymers, biomacromolecules to achieve effective encapsulation aggregation. Consequently, CD show great advantages improving drug-delivery efficiency, luminescence properties materials, molecular recognition imaging, toughness hydrogels, addition enabling multistimuli-responsive assemblies. These features are anticipated not only promote development CD-based chemistry but also contribute rapid exploitation these diverse interdisciplinary

Language: Английский

Citations

170
Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects DOI

Shuang Zeng,

Xiaosheng Liu, Yves S. Kafuti

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5607 - 5651

Published: Jan. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Language: Английский

Citations

153
Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes DOI
Ya‐Lin Qi,

Yunzhan Li,

Ming-Jun Tan

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215130 - 215130

Published: April 10, 2023

Language: Английский

Citations

92
Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications DOI

Chonglu Li,

Yida Pang,

Yuling Xu

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

Citations

88
Activatable NIR-II organic fluorescent probes for bioimaging DOI Creative Commons
Xiaoning Zhang, Shasha Li, Huizhen Ma

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(7), P. 3345 - 3371

Published: Jan. 1, 2022

NIR-II imaging is developed rapidly for noninvasive deep tissue inspection with high spatio-temporal resolution, taking advantage of diminished autofluorescence and light attenuation.Activatable fluorescence probes are widely to report pathological changes accurate targeting, among which organic fluorescent achieve significant progress.Furthermore, the activatable exhibited appealing characteristics like tunable physicochemical optical properties, easy processability, excellent biocompatibility.In present review, we highlight advances in design, synthesis applications reactive oxygen species (ROS), nitrogen (RNS), sulfur (RSS), pH, hypoxia, viscosity as well abnormally expressed enzymes.This non-invasive modality shows a promising prospect targeting site envisioned potential clinical translation.

Language: Английский

Citations

74
Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice DOI
Chenxu Yan, Jianfeng Dai,

Yongkang Yao

et al.

Nature Protocols, Journal Year: 2023, Volume and Issue: 18(4), P. 1316 - 1336

Published: Jan. 25, 2023

Language: Английский

Citations

63
Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing DOI
Gangwei Jiang, Han Liu, Hong Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(11)

Published: Dec. 12, 2023

Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance

Language: Английский

Citations

51
A Space‐Dependent ‘Enzyme‐Substrate’ Type Probe based on ‘Carboxylesterase‐Amide Group’ for Ultrafast Fluorescent Imaging Orthotopic Hepatocellular Carcinoma DOI Creative Commons
Ying Wen, Jing Ning, Min Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(8)

Published: Jan. 18, 2023

Abstract Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis remains significant challenge due complex physical environment. Human carboxylesterase (CE) is expected be potential of hepatocellular carcinoma (HCC) improve the accuracy diagnosis. However, existing probes CE has slow response rate low selectivity. Herein, amide group selected as CE‐responsive sites based on “substrate‐hydrolysis enzymatic reaction” approach. From series off–on with leave groups in unit, probe J screened optimal combination rapid high selectivity toward CE. requires only 150 s reach maximum at 676 nm presence free from interference other esterase. Computational docking simulations indicate shortest distance between active site . Cell vivo present that can turn liver cancer cells tumor region precisely. Importantly, allowed specifically image orthotopic rather than metastatic distinguish human primary tissue adjacent ones. This study provides new tool detection promotes advancements accurate HCC

Language: Английский

Citations

43
Dihydroxanthene-Based Near-infrared Fluorescent Probes for Monitoring Mitochondrial Viscosity in Living Cells and Mice DOI
Xue Wu,

Guanyu Fu,

Ying Li

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(6), P. 3544 - 3549

Published: Feb. 6, 2023

Aberrant mitochondrial viscosity is closely associated with many diseases and cellular malfunctions. Thus, the development of reliable methods for monitoring variations has attracted considerable attention. Herein, through stepwise structural modulation dihydroxanthene fluorophore (DHX), we developed three NIR fluorescent probes, named DHX-V-1-3, detecting viscosity. Among them, DHX-V-3 displayed highest signal-to-noise ratio (67-fold) outstanding selectivity showed excellent mitochondria targeting immobilization ability. At level, probe was successfully applied to image in live cells upon treatment lipopolysaccharide (LPS) or nystatin. Moreover, benefiting from its emission increased depth tissue imaging, demonstrated ability visualize LPS-treated mice.

Language: Английский

Citations

42