Enhanced cGAS‐STING Activation and Immune Response by LPDAM Platform‐Based Lapachone–Chemical–Photothermal Synergistic Therapy for Colorectal Cancer DOI Open Access
Xiaoyu Pan,

Yan Lin,

Chunlin Lin

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract The cGAS‐STING signaling pathway is a pivotal immune response mechanism that bridges tumor and cell interactions. This study describes multifunctional LPDAM nanoplatform integrating Lapachone, polydopamine (PDA), Mn 2+ , which synergistically kills cells activates the pathway, thereby inducing DC maturation T activation to achieve potent antitumor immunity. In microenvironment, Lapachone generates H 2 O via NAD(P)H:quinone oxidoreductase 1 (NQO1 enzyme), while catalyze conversion into •OH through chemodynamic effects (CDT). photothermal (PTT) of PDA further amplify this cascade reaction, producing reactive oxygen species (ROS) damage mitochondria release mitochondrial DNA (mtDNA). released mtDNA enhances sensitivity cGAS mtDNA, leading robust Concurrently, photothermal‐induced immunogenic death (ICD) promotes d endritic ( DCs) maturation, strengthening responses. Moreover, ⁺ also serves as contrast agent for T1‐weighted magnetic resonance imaging (MRI), offering precise visualization. demonstrates facilitates Lapachone/CDT/PTT synergistic therapy under MRI guidance, showcasing its potential an innovative strategy combined immunotherapy in clinical oncology.

Language: Английский

Stimuli-activatable nanomedicine meets cancer theranostics DOI Creative Commons
Haonan Li, Feng Yue, Qiang Luo

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

Citations

147
Biomarker-driven molecular imaging probes in radiotherapy DOI Creative Commons
Haonan Li, Qiyong Gong, Kui Luo

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146

Published: Jan. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Language: Английский

Citations

78
Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

Citations

31
A cuproptosis nanocapsule for cancer radiotherapy DOI
You Liao, Dongmei Wang,

Chenglu Gu

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

Citations

23
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4
Nanomedicine Combats Drug Resistance in Lung Cancer DOI
Xiuli Zheng, Xiao-Hai Song,

Guonian Zhu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Nov. 16, 2023

Lung cancer is the second most prevalent and leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, radiotherapy are currently available as treatment methods. However, drug resistance a significant factor in failure lung treatments. Novel therapeutics have been exploited to address complicated mechanisms advancement nanomedicine extremely promising terms overcoming resistance. Nanomedicine equipped with multifunctional tunable physiochemical properties alignment tumor genetic profiles can achieve precise, safe, effective while minimizing or eradicating cancer. Here, this work reviews discovered for radiotherapy, outlines novel strategies development against This focuses on engineering design, customized delivery, current challenges, clinical translation application resistant

Language: Английский

Citations

36
A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer DOI
Lele Zhou, Qun Guan, Wei Zhou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20445 - 20461

Published: Oct. 6, 2023

Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis an iodine- ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for enhancement radiotherapeutic efficacy in treatment radioresistant esophageal cancer. The iodine atoms on COF not only exerted a direct effect radiotherapy, increasing its X-ray absorption, but also promoted radiolysis water, increased production reactive oxygen species (ROS). In addition, ferrocene surface decoration disrupted redox homeostasis levels hydroxyl lipid peroxide radicals depleting intracellular antioxidants. Both vitro vivo experiments substantiated excellent response TADI-COF-Fc. This study demonstrates potential COF-based multinanozymes as radiosensitizers suggests possible integration strategy combination oncotherapy.

Language: Английский

Citations

35
Monitoring ROS Responsive Fe3O4‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via 129Xe MRI DOI
Lei Zhang, Maosong Qiu, Ruifang Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(22)

Published: March 29, 2024

The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, low response limits immunotherapy efficiency. Here, we report a ROS-responsive Fe

Language: Английский

Citations

15
Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization DOI Creative Commons

Rui Qiao,

Zhongwen Yuan,

Meijin Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Language: Английский

Citations

13
Intracellular and extracellular synergistic therapy for restoring macrophage functions via anti-CD47 antibody-conjugated bifunctional nanoparticles in atherosclerosis DOI Creative Commons
Qiang Luo, Liqun Dai, Junli Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 326 - 337

Published: Jan. 5, 2024

Atherosclerosis is a significant contributor to global cardiovascular disease. Reducing the formation of atherosclerotic plaque effectively can lead decrease in diseases. Therefore, controlling macrophage function crucial. This study presents creation bifunctional nanoparticle that specific macrophages achieve intracellular and extracellular synergistic therapy for restoring functions. The conjugated with anti-CD47 antibody modulate CD47-SIRPα phagocytic signaling axis on outer surface encapsulates NLRP3 inhibitor (CY-09) regulate inflammation response macrophages. results showed nanoparticles accumulate plaque, alter phagocytosis, inhibit inflammasome activation, burden Apoe−/− mice whilst ensuring safety. Examination single-cell RNA sequencing indicates this multifunctional decreases expression genes linked manages inflammatory pathways lesion. proposes therapeutic approach utilizes nanoparticle, anti-CD47, microenvironment plaques.

Language: Английский

Citations

10