Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155437 - 155437

Published: Feb. 9, 2024

Language: Английский

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Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis by inhibiting polymerase I and transcript release factor and the TLR4/JNK/NF-κB/MyD88 pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 314, P. 116662 - 116662

Published: May 18, 2023

Language: Английский

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Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 52, P. 151 - 170

Published: June 2, 2023

The relationship between gut microbiota and human health has gradually been recognized. Increasing studies show that the disorder of is related to occurrence development many diseases. Metabolites produced by are responsible for their extensive regulatory roles. In addition, naturally derived medicine food homology species with low toxicity high efficiency have clearly defined owing outstanding physiological pharmacological properties in disease prevention treatment.Based on supporting evidence, current review summarizes representative work targeting regulate host pathophysiology discusses challenges prospects this field. It aims facilitate understanding among species, microbiota, further stimulate advancement more relevant research.As reveals, from initial practical application mechanism studies, evolved into an irrefutable interaction. On one hand, through affecting population structure, metabolism, function maintain homeostasis intestinal microenvironment microbiota. other also involved bioconversion active ingredients thus influences properties.

Language: Английский

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Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 252, P. 126484 - 126484

Published: Aug. 23, 2023

Language: Английский

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Raspberry polysaccharides attenuate hepatic inflammation and oxidative stress in diet-induced obese mice by enhancing butyrate-mediated intestinal barrier function

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 130007 - 130007

Published: Feb. 8, 2024

Language: Английский

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Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2838 - 2838

Published: Aug. 24, 2024

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds millions years. Over the past decade, growing body knowledge has underscored intricate connections among diet, microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, fungi diverse biological functions including antioxidant, immunoregulatory, metabolic activities. Their effects are closely tied to which metabolizes BPs into health-influencing compounds. Understanding how interact is critical for harnessing potential health benefits. This review provides an overview focusing on its role in diseases obesity, type II diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular diseases. It explores basic characteristics several impact microbiota. Given significance health, we summarize these BPs, particularly terms immunoregulatory activities, blood sugar, hypolipidemic effect, thus providing valuable reference understanding benefits treating These properties make promising agents preventing comprehensive mechanisms by exert through opens new avenues developing targeted therapies improve

Language: Английский

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Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

Food & Function, Journal Year: 2022, Volume and Issue: 13(24), P. 12883 - 12895

Published: Jan. 1, 2022

The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years. In this study, a homogeneous polysaccharide, PCP1, was extracted from P. rhizomes purified. Monosaccharide composition analysis showed that PCP1 is primarily composed fructose, glucose, mannose. Chemical the main chain mainly →1)-β-D-Fruf-(2→ →1,6)-β-D-Fruf-(2→, with small amounts →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, β-D-Glcp-(1→. side β-D-Fruf-(2→ linked at C-6 →1,6)-β-D-Fruf-(2→. vivo experiments mitigates liver pathological damage, improves abnormal lipid metabolism oxidative stress, promotes production short-chain fatty acids, balances intestinal microbiota non-alcoholic disease (NAFLD) mice. Thus, can be used as natural ingredient functional foods for treatment NAFLD.

Language: Английский

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Modulating effects of Astragalus polysaccharide on immune disorders via gut microbiota and the TLR4/NF-κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency

Journal of Zhejiang University SCIENCE B, Journal Year: 2023, Volume and Issue: 24(7), P. 650 - 662

Published: July 1, 2023

Language: Английский

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Polysaccharides: The Potential Prebiotics for Metabolic Associated Fatty Liver Disease (MAFLD)

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3722 - 3722

Published: Aug. 25, 2023

Metabolic (dysfunction) associated fatty liver disease (MAFLD) is recognized as the most prevalent chronic globally. However, its pathogenesis remains incompletely understood. Recent advancements in gut-liver axis offer novel insights into development of MAFLD. Polysaccharides, primarily derived from fungal and algal sources, abundantly exist human diet exert beneficial effects on glycometabolism, lipid metabolism, inflammation, immune modulation, oxidative stress, release Numerous studies have demonstrated that these bioactivities polysaccharides are with their prebiotic properties, including ability to modulate gut microbiome profile, maintain barrier integrity, regulate metabolites produced by microbiota such lipopolysaccharide (LPS), short-chain acids (SCFAs), bile (BAs), contribute intestinal homeostasis. This narrative review aims present a comprehensive summary current understanding protective MAFLD through interactions metabolites. Specifically, we highlight potential molecular mechanisms underlying polysaccharides, which may give new avenues for prevention treatment

Language: Английский

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Beneficial effect and mechanism of natural resourced polysaccharides on regulating bone metabolism through intestinal flora: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127428 - 127428

Published: Oct. 13, 2023

Language: Английский

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