Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(9), P. 1202 - 1213.e6

Published: July 29, 2021

Language: Английский

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Multiomics to elucidate inflammatory bowel disease risk factors and pathways

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(6), P. 399 - 409

Published: March 17, 2022

Language: Английский

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Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Jan. 27, 2023

Recently, mesenchymal stem/stromal cells (MSCs) therapy has become an emerging therapeutic modality for the treatment of inflammatory bowel disease (IBD), given their immunoregulatory and pro-survival attributes. MSCs alleviate dysregulated responses through secretion a myriad anti-inflammatory mediators, such as interleukin 10 (IL-10), transforming growth factor-β (TGFβ), prostaglandin E2 (PGE2), tumor necrosis factor-stimulated gene-6 (TSG-6), etc. Indeed, MSC IBD is largely carried out local microcirculation construction, colonization repair, immunomodulation, thus alleviating diseases severity. The clinical efficacy relies on to marked various secretory molecules from viable via paracrine mechanisms that are required gut immuno-microbiota regulation proliferation differentiation surrounding like intestinal epithelial (IECs) stem (ISCs). For example, can induce IECs upregulate expression tight junction (TJs)-associated protein, ensuring barrier integrity. Concerning encouraging results derived animal studies, trials conducted or ongoing address safety administration in patients. Although short-term have been evinced, long-term transplantation not yet verified. Herein, we emphasized illumination capacity therapy, including naïve MSCs, preconditioned also MSCs-derived exosomes, severity experimental models. Also, brief overview published patients delivered.

Language: Английский

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The hyphal-specific toxin candidalysin promotes fungal gut commensalism

Nature, Journal Year: 2024, Volume and Issue: 627(8004), P. 620 - 627

Published: March 6, 2024

Language: Английский

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Myeloid C-type lectin receptors in innate immune recognition

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 700 - 717

Published: April 1, 2024

C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of that play key role in innate immune recognition. Myeloid CLRs exhibit remarkable ability to recognize an extensive array ligands, from carbohydrates and beyond, encompass pattern-associated molecular patterns (PAMPs), damage-associated (DAMPs), markers altered self. These receptors, classified into distinct subgroups, pivotal roles recognition modulation responses. Their intricate signaling pathways orchestrate spectrum cellular responses, influencing processes such as phagocytosis, cytokine production, antigen presentation. Beyond their contributions host defense viral, bacterial, fungal, parasitic infections, have been implicated non-infectious diseases cancer, allergies, autoimmunity. A nuanced understanding CLR interactions with endogenous microbial triggers is starting uncover the context-dependent nature immunity, implications for therapeutic intervention.

Language: Английский

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Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: April 13, 2021

The relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the mycobiota of 67 patients, 35 H1N1-infected patients 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing analysed their associations with clinical features bacterial microbiota. Compared to HCs, fungal burden was higher. Fungal dysbiosis in both mainly characterized by depletion fungi such as Aspergillus Penicillium, but several fungi, including Candida glabrata, were enriched patients. profiles mild severe symptoms similar. Hospitalization had no apparent additional effects. In Mucoromycota positively correlated Fusicatenibacter, niger diarrhoea, Penicillium citrinum negatively C-reactive protein (CRP). penicilloides Lachnospiraceae members, CRP, procalcitonin. Therefore, occurs does improve until are discharged longer require medical attention.

Language: Английский

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Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder

Cellular and Molecular Neurobiology, Journal Year: 2021, Volume and Issue: 42(8), P. 2571 - 2591

Published: Oct. 12, 2021

Language: Английский

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Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation

Science Immunology, Journal Year: 2022, Volume and Issue: 7(70)

Published: April 8, 2022

Altered enteric microorganisms in concert with host genetics shape inflammatory bowel disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that eukaryotic viruses bacteriophages (collectively, the virome), enriched from non-IBD, noninflamed human colon resections, actively elicited atypical anti-inflammatory innate immune programs. Conversely, ulcerative colitis or Crohn's resection viromes provoked inflammation, which was successfully dampened by non-IBD viromes. The IBD tissue virome perturbed, including an increase enterovirus B species of picornaviruses, not previously detected fecal studies. Mice humanized were protected intestinal whereas mice exhibited exacerbated inflammation a nucleic acid sensing-dependent fashion. Furthermore, there detrimental consequences for patient-derived epithelial cells bearing loss-of-function mutations within virus sensor MDA5 when exposed Our results demonstrate recognition autonomously influences homeostasis Thus, perturbations virome, altered ability sense due genetic variation, contribute induction IBD. Harnessing may offer therapeutic biomarker potential.

Language: Английский

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Roles of the gut virome and mycobiome in faecal microbiota transplantation

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2022, Volume and Issue: 7(5), P. 472 - 484

Published: March 8, 2022

Language: Английский

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The microbiota and the gut–liver axis in primary sclerosing cholangitis

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(3), P. 135 - 154

Published: Nov. 9, 2022

Language: Английский

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