Unimolecular Self-Assembled Hemicyanine–Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells DOI Creative Commons
Qiang Wang, Tian Yang, Shiyou Li

et al.

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells (CSCs). However, the innate drawbacks, including short lifetime and diffusion distance of hypoxia within solid tumors, have become bottlenecks for clinical applications photodynamic therapy. Here, we develop mitochondria-targeting hemicyanine–oleic acid conjugate (CyOA), which can self-assemble into supramolecular nanoparticles (NPs) without any exogenous excipients. CyOA also shown targeting mitochondrial complex II protein succinate dehydrogenase inhibit oxidative phosphorylation reverse tumor hypoxia, resulting in 50.4-fold higher phototoxicity against breast (BCSCs) compared SO 3 -CyOA NPs that cannot target mitochondria. In 4T1 BCSC models, achieve inhibition less lung metastasis nodules clinically used photosensitizer Hiporfin. This study develops self-assembled small molecule serve as both inhibitor eradication CSCs tumors.

Language: Английский

Nanomaterials-based photothermal therapies for antibacterial applications DOI Creative Commons
Hao Liu, Fei Xing, Yuxi Zhou

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

Citations

79
Nanomaterials for photothermal cancer therapy DOI Creative Commons

Shufan Duan,

Yanling Hu, Ying Zhao

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14443 - 14460

Published: Jan. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Language: Английский

Citations

76
Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives DOI Creative Commons
Shutao Zhang, Hongtao Yang, Minqi Wang

et al.

The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503

Published: Aug. 29, 2023

•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.

Language: Английский

Citations

60
Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications DOI Creative Commons

Nan Yang,

Changyu Cao,

Xinyi Lv

et al.

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 16, 2023

Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.

Language: Английский

Citations

55
Pore-engineered nanoarchitectonics for cancer therapy DOI Creative Commons
Linawati Sutrisno, Katsuhiko Ariga

NPG Asia Materials, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 31, 2023

Abstract Nanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics application targets for cancer therapy by combining basic descriptions and exemplifying applications in review. The initial two sections briefly summarize basics according classification based (i) porosity (ii) composition. Afterward, main application-oriented section—designing mesoporous therapy—is presented. Various types drug delivery systems, including nanoparticles nanocarriers, endogenous stimuli-responsive delivery, exogenous targeted are described. Importantly, clinical translation materials is further discussed. Mesoporous unique offer network cavities vehicles nanocarriers. Regarding developments allow be broadly used settings, there several challenges should solved their application. From perspective, tremendous processes development materials.

Language: Английский

Citations

43
Light‐Guided Genetic Scissors Based on Phosphorene Quantum Dot DOI
Zhi Chen, Hao Huang,

Jiefeng Deng

et al.

Laser & Photonics Review, Journal Year: 2024, Volume and Issue: 18(11)

Published: July 10, 2024

Abstract Genetic engineering faces persistent challenges in achieving precise Deoxyribonucleic acid (DNA) cleavage, especially with the limitations associated current enzyme‐based methods, exemplified by issues CRISPR technologies. This study introduces a groundbreaking approach: utilizing reactive oxygen species (ROS) generated Multiphoton Absorption (MPA)‐excited Black Phosphorus Quantum Dots (BPQDs) under femto‐second laser irradiation. innovative method not only allows excitation lower energy but also enhances overall efficiency. The integration of complementary RNA sequences facilitates high‐efficiency, site‐selective DNA cleavage system, named “TADPOLE” (Targeted Precision Oriented Laser Excision). Beyond its precision targeting arbitrary using quantum dots, TADPOLE harnesses unique multiphoton absorption property BPQDs, enabling lower‐energy light sources suitable for vivo applications future. Moreover, approach integrates guiding and ultrafast technology to provide control over local ROS generation minimal heat production. guarantees site‐specific while mitigating risk damage non‐targeted sequences. In summary, this catalyzes advancements enzyme‐free technologies, transformative implications genetic engineering, biotechnology, medicine. holistic precision, versatility, endurance presented open new avenues targeted gene therapies related fields.

Language: Английский

Citations

30
Zero-dimensional nano-carbons: Synthesis, properties, and applications DOI
Darwin Kurniawan, Zhenhai Xia, Liming Dai

et al.

Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(2)

Published: April 19, 2024

Zero-dimensional (0D) nano-carbons, including graphene quantum dots, nanodiamonds, and carbon represent the new generation of carbon-based nanomaterials with exceptional properties arising from diverse phenomena, such as surface, size, edge effects, which strongly depend on carbon–carbon bond configuration (sp2, sp3, a mixture sp2 sp3) particle size. Their unique physicochemical properties, optical, electronic, magnetic, reactivity, catalytic are valuable for energy conversion storage, sensing, catalysis, optoelectronic devices, modern nanotechnologies, biomedical, many other applications. This review aims to provide insights into distinctive effects 0D nano-carbon microstructures their that crucial cutting-edge fundamental studies broad range multifunctional The key synthesis methods different types nano-carbons current advances characterization computational techniques study structures structure–property relationships also discussed. concludes status, challenges, future opportunities in this rapidly developing research field.

Language: Английский

Citations

19
Gold Nanorods-Based Photothermal Therapy: Interactions Between Biostructure, Nanomaterial, and Near-Infrared Irradiation DOI Creative Commons

Ruili Zhou,

Meigui Zhang,

Jiahui Xi

et al.

Nanoscale Research Letters, Journal Year: 2022, Volume and Issue: 17(1)

Published: July 26, 2022

Gold nanorods (AuNRs) are ideal inorganic nanophotothermal agents with unique characteristics, including local surface plasmon resonance effects, easy scale preparation and functional modification, good biocompatibility. This review summarizes several recent advances in AuNRs-based photothermal therapy (PTT) research. Functionalized AuNRs have optimized biocompatibility targeting properties. The multifunctional nanoplatform composite structure meets the requirements for synergistic effects of PTT, photoacoustic imaging, other therapeutic methods. Photothermal (AuNRs-PTT) is widely used to treat tumors inflammatory diseases; its tumor-targeting, tumor metastasis inhibition, ablation abilities remarkable curative effects. An in-depth study living systems interactions between biological structure, nanomaterial, near-infrared irradiation could lay foundation further clinical research broad application PTT.

Language: Английский

Citations

45
Single-molecule photosensitizers for NIR-II fluorescence and photoacoustic imaging guided precise anticancer phototherapy DOI Creative Commons
Hua Gu, Weijian Liu, Wen Sun

et al.

Chemical Science, Journal Year: 2022, Volume and Issue: 13(33), P. 9719 - 9726

Published: Jan. 1, 2022

It is ideal yet challenging to achieve precise tumor targeting and high-quality imaging guided combined photodynamic photothermal therapy (PDT PTT). In this study, we synthesized a series of D-π-A-type single-molecule photosensitizers (CyE-TT, CyQN-TT, CyQN-BTT) based on quaternized 1,1,2-trimethyl-1H-benz[e]indoles as acceptors by introducing π-bridges elongate their emission wavelength triphenylamine donor construct twisted molecular conformation. We found that the 1O2 generation ability conversion efficiency (PCE) are directly correlated with π-bridge between donors in these molecules. When 2,1,3-benzothiadiazole group was introduced into CyQN-BTT, singlet oxygen yield enhanced 27.1%, PCE 37.8%, red-shifted near-infrared II (NIR-II). Importantly, double-cationic CyQN-BTT displays structure-inherent cancer cell instead normal cells. Consequently, relying NIR-II fluorescence (NIR-II FLI) photoacoustic (PAI) PDT PTT, can accurately locate solid tumors mice effectively eliminate them good biocompatibility biosafety tissues. This study provides insights design development tumor-specific multifunctional photosensitizer for phototherapy.

Language: Английский

Citations

43
Prospects of nanoparticle-based radioenhancement for radiotherapy DOI Creative Commons
Lukas R. H. Gerken,

Maren E. Gerdes,

Martin Pruschy

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(10), P. 4059 - 4082

Published: Jan. 1, 2023

Radiotherapy is a key pillar of solid cancer treatment. Despite high level conformal dose deposition, radiotherapy limited due to co-irradiation organs at risk and subsequent normal tissue toxicities. Nanotechnology offers an attractive opportunity for increasing the efficacy safety radiotherapy. Leveraging freedom design growing synthetic capabilities nanomaterial-community, variety engineered nanomaterials have been designed investigated as radiosensitizers or radioenhancers. While research so far has primarily focused on gold nanoparticles other atomic number materials increase absorption cross section tumor tissue, recent studies are challenging traditional concept high-

Language: Английский

Citations

38