Social jetlag, obesity and metabolic disorder: investigation in a cohort study

International Journal of Obesity, Journal Year: 2014, Volume and Issue: 39(5), P. 842 - 848

Published: Dec. 22, 2014

Language: Английский

---

Role of sleep deprivation in immune-related disease risk and outcomes

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Nov. 18, 2021

Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects deprivation on Sleep exerts immune-supportive function, promoting host defense against infection inflammatory insults. has been associated alterations innate adaptive immune parameters, leading to a chronic state increased risk infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune neurodegenerative diseases. Here, we review recent advancements responses as evidenced by experimental epidemiological studies, pathophysiology, role deprivation-induced changes in Gaps knowledge methodological pitfalls still remain. Further understanding causal relationship between deregulation would help identify individuals at disease prevent adverse health outcomes.

Language: Английский

---

The role of insufficient sleep and circadian misalignment in obesity

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(2), P. 82 - 97

Published: Oct. 24, 2022

Language: Английский

---

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Cell, Journal Year: 2019, Volume and Issue: 177(4), P. 896 - 909.e20

Published: April 25, 2019

In mammals, endogenous circadian clocks sense and respond to daily feeding lighting cues, adjusting internal ∼24 h rhythms resonate with, anticipate, external cycles of day night. The mechanism underlying entrainment time is critical for understanding why mistimed feeding, as occurs during shift work, disrupts physiology, a state that associated with increased incidence chronic diseases such type 2 (T2) diabetes. We show feeding-regulated hormones insulin insulin-like growth factor 1 (IGF-1) reset in vivo vitro by induction PERIOD proteins, signaling organization mouse behavior clock gene expression. Insulin IGF-1 receptor sufficient determine essential parameters, principally via protein synthesis. This requires coincident mechanistic target rapamycin (mTOR) activation, phosphoinositide signaling, microRNA downregulation. Besides its well-known homeostatic functions, we propose are primary signals cellular throughout the body.

Language: Английский

---

Associations between chronotype, morbidity and mortality in the UK Biobank cohort

Chronobiology International, Journal Year: 2018, Volume and Issue: unknown, P. 1 - 9

Published: April 11, 2018

Later chronotype (i.e. evening preference) and later timing of sleep have been associated with greater morbidity, including higher rates metabolic dysfunction cardiovascular disease (CVD). However, no one has examined whether is mortality risk to date. Our objective was test the hypothesis that being an type increased in a large cohort study, UK Biobank. analysis included 433 268 adults aged 38-73 at time enrolment average 6.5-year follow-up. The primary exposure chronotype, as assessed through single self-reported question-defining participants definite morning types, moderate types or types. outcomes were all-cause due CVD. Prevalent also compared among groups. Analyses adjusted for age, sex, ethnicity, smoking, body mass index, duration, socioeconomic status comorbidities. Greater eveningness, particularly type, significantly prevalence all Comparing associations strongest psychological disorders (OR 1.94, 95% CI 1.86-2.02, p = < 0.001), followed by diabetes 1.30, 1.24-1.36, neurological 1.25, 1.20-1.30, gastrointestinal/abdominal 1.23, 1.19-1.27, 0.001) respiratory 1.22, 1.18-1.26, 0.001). total number deaths 10 534, out which 2127 based on ordinal variable, small (HR 1.02, 1.004-1.05, 0.017) CVD 1.04, 1.00-1.09, 0.06). Compared had 1.10, 1.02-1.18, 0.012). This first report consistent previous reports levels cardiometabolic factors this group. Mortality may be behavioural, physiological factors, many attributable chronic misalignment between internal externally imposed work social activities. These findings suggest need researching possible interventions aimed either modifying circadian rhythms individuals allowing working hour flexibility.

Language: Английский

---

High-accuracy determination of internal circadian time from a single blood sample

Journal of Clinical Investigation, Journal Year: 2018, Volume and Issue: 128(9), P. 3826 - 3839

Published: June 28, 2018

BACKGROUND. The circadian clock is a fundamental and pervasive biological program that coordinates 24-hour rhythms in physiology, metabolism, behavior, it essential to health. Whereas therapy adapted time of day increasingly reported be highly successful, needs personalized, since internal different for each individual. In addition, not stable trait, but influenced by many factors, including genetic predisposition, age, sex, environmental light levels, season. An easy convenient diagnostic tool currently missing.

Language: Английский

---

CYCLOPS reveals human transcriptional rhythms in health and disease

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(20), P. 5312 - 5317

Published: April 24, 2017

Circadian rhythms modulate many aspects of physiology. Knowledge the molecular basis these has exploded in last 20 years. However, most data are from model organisms, and translation to clinical practice been limited. Here, we present an approach identify humans thousands unordered expression measurements. Our algorithm, cyclic ordering by periodic structure (CYCLOPS), uses evolutionary conservation machine learning elliptical high-dimensional data. From this structure, CYCLOPS estimates phase each sample. We validated using temporally ordered mouse human demonstrated its consistency on two independent research sites. used rhythmic transcripts liver lung, including hundreds drug targets disease genes. Importantly, for genes, circadian variation exceeded genetic other environmental factors. also analyzed hepatocellular carcinoma samples show solid tumors maintain function but with aberrant output. Finally, how method can catalyze medical translation, that dosage time segregate efficacy dose-limiting toxicity streptozocin, a chemotherapeutic drug. In sum, power temporal reconstruction bridging basic medicine.

Language: Английский

---

Disturbance of the Circadian System in Shift Work and Its Health Impact

Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 37(1), P. 3 - 28

Published: Dec. 30, 2021

The various non-standard schedules required of shift workers force abrupt changes in the timing sleep and light-dark exposure. These result disturbances endogenous circadian system its misalignment with environment. Simulated night-shift experiments field-based studies both indicate that is resistant to adaptation from a day- night-oriented schedule, as determined by lack substantial phase shifts over multiple days centrally controlled rhythms, such those melatonin cortisol. There evidence disruption caused work results not only between external cycle, but also state internal desynchronization levels system. This case rhythms central pacemaker clock genes expression tissues peripheral blood mononuclear cells, hair follicle oral mucosa cells. disruptive effects atypical extend beyond profile canonical affects other transcripts human genome. In general, after several living at night, most rhythmic genome remain adjusted day-oriented dampened group amplitudes. contrast transcripts, metabolomics revealed metabolites hours when working nights, thus leading their Altogether, these sleep-wake emphasize all-encompassing impact work, can contribute increased risk medical conditions. Here, we review latest scientific regarding on system, alertness shift-working populations, discuss potential clinical impacts.

Language: Английский

---

Exploring phylogeny to find the function of sleep

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 20(2), P. 109 - 116

Published: Dec. 20, 2018

Language: Английский

---

Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans

Advances in Nutrition, Journal Year: 2016, Volume and Issue: 7(2), P. 399 - 406

Published: March 1, 2016

Language: Английский

---