Journal of Biological Rhythms,
Journal Year:
2017,
Volume and Issue:
32(2), P. 154 - 164
Published: March 27, 2017
Shift
work
is
a
risk
factor
for
inflammation,
hypertension,
and
cardiovascular
disease.
This
increased
cannot
be
fully
explained
by
classical
factors.
workers’
behavioral
environmental
cycles
are
typically
misaligned
relative
to
their
endogenous
circadian
system.
However,
there
little
information
on
the
impact
of
acute
misalignment
disease
in
shift
workers,
independent
differences
stress,
food
quality,
other
factors
that
likely
differ
between
night
day
shifts.
Thus,
our
objectives
were
determine
effect
24-h
high-sensitivity
C-reactive
protein
(hs-CRP;
marker
systemic
inflammation)
blood
pressure
levels—cardiovascular
factors—in
chronic
workers.
Chronic
workers
undertook
two
3-day
laboratory
protocols
simulated
work,
comprising
12-hour
inverted
(circadian
misalignment)
or
alignment),
using
randomized,
crossover
design.
Circadian
hs-CRP
11%
(
p
<
0.0001).
systolic
(SBP)
diastolic
(DBP)
1.4
mmHg
0.8
mmHg,
respectively
(both
≤
0.038).
The
misalignment-mediated
increase
SBP
was
primarily
an
during
wake
period
(+1.7
mmHg;
=
0.017),
whereas
DBP
sleep
opportunity
(+1.8
0.005).
per
se
increases
may
help
explain
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Nov. 7, 2022
Abstract
Aging
is
accompanied
by
the
decline
of
organismal
functions
and
a
series
prominent
hallmarks,
including
genetic
epigenetic
alterations.
These
aging-associated
changes
include
DNA
methylation,
histone
modification,
chromatin
remodeling,
non-coding
RNA
(ncRNA)
regulation,
all
which
participate
in
regulation
aging
process,
hence
contribute
to
aging-related
diseases.
Therefore,
understanding
mechanisms
will
provide
new
avenues
develop
strategies
delay
aging.
Indeed,
interventions
based
on
manipulating
have
led
alleviation
or
extension
lifespan
animal
models.
Small
molecule-based
therapies
reprogramming
that
enable
rejuvenation
been
developed
for
ameliorating
reversing
conditions.
In
addition,
adopting
health-promoting
activities,
such
as
caloric
restriction,
exercise,
calibrating
circadian
rhythm,
has
demonstrated
Furthermore,
various
clinical
trials
intervention
are
ongoing,
providing
more
evidence
safety
efficacy
these
therapies.
Here,
we
review
recent
work
outline
advances
age-associated
A
better
critical
roles
epigenetics
process
lead
prevention
human
therapy
Journal of Clinical Investigation,
Journal Year:
2021,
Volume and Issue:
131(19)
Published: Sept. 30, 2021
Circadian
disruption
is
pervasive
and
can
occur
at
multiple
organizational
levels,
contributing
to
poor
health
outcomes
individual
population
levels.
Evidence
points
a
bidirectional
relationship,
in
that
circadian
increases
disease
severity
many
diseases
disrupt
rhythms.
Importantly,
increase
the
risk
for
expression
development
of
neurologic,
psychiatric,
cardiometabolic,
immune
disorders.
Thus,
harnessing
rich
findings
from
preclinical
translational
research
biology
enhance
via
circadian-based
approaches
represents
unique
opportunity
personalized/precision
medicine
overall
societal
well-being.
In
this
Review,
we
discuss
implications
human
using
bench-to-bedside
approach.
science
applied
clinical
population-based
Given
broad
regulation
health,
Review
focuses
its
discussion
on
selected
examples
metabolic,
cardiovascular,
allergic,
immunologic
disorders
highlight
interrelatedness
between
potential
interventions,
such
as
bright
light
therapy
exogenous
melatonin,
well
chronotherapy
improve
and/or
modify
outcomes.
Journal of Biological Rhythms,
Journal Year:
2021,
Volume and Issue:
37(1), P. 3 - 28
Published: Dec. 30, 2021
The
various
non-standard
schedules
required
of
shift
workers
force
abrupt
changes
in
the
timing
sleep
and
light-dark
exposure.
These
result
disturbances
endogenous
circadian
system
its
misalignment
with
environment.
Simulated
night-shift
experiments
field-based
studies
both
indicate
that
is
resistant
to
adaptation
from
a
day-
night-oriented
schedule,
as
determined
by
lack
substantial
phase
shifts
over
multiple
days
centrally
controlled
rhythms,
such
those
melatonin
cortisol.
There
evidence
disruption
caused
work
results
not
only
between
external
cycle,
but
also
state
internal
desynchronization
levels
system.
This
case
rhythms
central
pacemaker
clock
genes
expression
tissues
peripheral
blood
mononuclear
cells,
hair
follicle
oral
mucosa
cells.
disruptive
effects
atypical
extend
beyond
profile
canonical
affects
other
transcripts
human
genome.
In
general,
after
several
living
at
night,
most
rhythmic
genome
remain
adjusted
day-oriented
dampened
group
amplitudes.
contrast
transcripts,
metabolomics
revealed
metabolites
hours
when
working
nights,
thus
leading
their
Altogether,
these
sleep-wake
emphasize
all-encompassing
impact
work,
can
contribute
increased
risk
medical
conditions.
Here,
we
review
latest
scientific
regarding
on
system,
alertness
shift-working
populations,
discuss
potential
clinical
impacts.
Cardiovascular Research,
Journal Year:
2021,
Volume and Issue:
118(14), P. 2880 - 2902
Published: Sept. 30, 2021
Abstract
Non-communicable
diseases
(NCDs)
are
fatal
for
more
than
38
million
people
each
year
and
thus
the
main
contributors
to
global
burden
of
disease
accounting
70%
mortality.
The
majority
these
deaths
caused
by
cardiovascular
(CVD).
risk
NCDs
is
strongly
associated
with
exposure
environmental
stressors
such
as
pollutants
in
air,
noise
exposure,
artificial
light
at
night,
climate
change,
including
heat
extremes,
desert
storms,
wildfires.
In
addition
traditional
factors
CVD
diabetes,
arterial
hypertension,
smoking,
hypercholesterolaemia,
genetic
predisposition,
there
a
growing
body
evidence
showing
that
physicochemical
environment
contribute
significantly
high
NCD
numbers.
Furthermore,
urbanization
accumulation
intensification
stressors.
This
comprehensive
expert
review
will
summarize
epidemiology
pathophysiology
focus
on
NCDs.
We
also
discuss
solutions
mitigation
measures
lower
impact
CVD.
