Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(12), P. 4258 - 4278

Published: Jan. 1, 2018

Recent advances in the chemical design and synthesis of fluorophores second near-infrared biological window (NIR-II) for multimodal imaging theranostics are summarized highlighted this review article.

Language: Английский

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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

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Recent Advances of Optical Imaging in the Second Near‐Infrared Window

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(47)

Published: Sept. 4, 2018

Abstract The near‐infrared window between 1000 and 1700 nm, commonly termed the “second (NIR‐II) window,” has quickly emerged as a highly attractive optical region for biological imaging. In contrast to conventional imaging in visible 400 700 well first NIR (NIR‐I) 900 NIR‐II offers numerous merits, including higher spatial resolution, deeper penetration depth, lower absorption scattering from substrates with minimal tissue autofluorescence. Noninvasive techniques, specifically fluorescence photoacoustic (PA) imaging, have embodied attractiveness of several agents demonstrating superior performance clinically approved NIR‐I agents. Consequently, been increasingly explored due its tremendous potential preclinical studies clinical utility. Herein, progress is reported. Starting highlighting importance spectral region, emergence latest development various PA probes their applications are then discussed. Perspectives on promises challenges facing this nascent yet exciting field given.

Language: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

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Dual‐Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near‐Infrared Window Photothermal Therapy: A Comparative Study

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(14)

Published: Feb. 19, 2018

Near-infrared (NIR) light is widely used for noninvasive optical diagnosis and phototherapy. However, current research focuses on the first NIR window (NIR-I, 650-950 nm), while second (NIR-II, 1000-1700 nm) far less exploited. The development of organic photothermal nanoagent (SPNI-II ) with dual-peak absorption in both windows its utilization therapy (PTT) are reported herein. Such a comprises semiconducting copolymer two distinct segments that respectively identically absorb at 808 1064 nm. With conversion efficiency 43.4% nm generally higher than other inorganic nanomaterials, SPNI-II enables superior deep-tissue heating over their respective safety limits. Model cancer PTT tissue depth 5 mm validates enhanced antitumor effect when shifting laser irradiation from NIR-I to NIR-II window. good biodistribution facile synthesis also allow it be doped an dye fluorescence-imaging-guided through systemic administration. Thus, this study paves way new polymeric nanomaterials advance

Language: Английский

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In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

Nature Biotechnology, Journal Year: 2019, Volume and Issue: 37(11), P. 1322 - 1331

Published: Sept. 30, 2019

Language: Английский

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Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(30), P. 16294 - 16308

Published: Aug. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Language: Английский

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Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(49)

Published: July 29, 2018

Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration poor signal-to-background ratio due to light scattering autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, photoacoustic have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time excitation, detect acoustic signals negligible attenuation, respectively. Because there are only few endogenous molecules absorbing or emitting above the visible region, development contrast agents is essential for those deep-tissue modalities. Organic semiconducting π-conjugated frameworks can be synthesized meet different requirements their easy chemical modification legible structure-property relation. Herein, applications organic including small-molecule nanoparticle derivatives summarized. In particular, molecular engineering nanoformulation approaches further improve detection sensitivity modalities highlighted. Finally, current potential opportunities this emerging subfield biomedical discussed.

Language: Английский

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Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm

Nature Communications, Journal Year: 2017, Volume and Issue: 8(1)

Published: Sept. 25, 2017

Abstract In vivo fluorescence imaging in the near-infrared region between 1500–1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to suppressed scattering of long-wavelength photons large fluorophore Stokes shifts. However, very few NIR-IIb fluorescent probes exist currently. Here, we report synthesis a down-conversion luminescent rare-earth nanocrystal with cerium doping (Er/Ce co-doped NaYbF 4 core an inert NaYF shell). Ce is found suppress up-conversion pathway while boosting by ~9-fold produce bright 1550 luminescence under 980 excitation. Optimization shell coating surrounding hydrophilic surface functionalization minimize quenching effect water. The resulting biocompatible, emitting nanoparticles enable fast blood vasculature mouse brain hindlimb window short exposure time 20 ms for based probes.

Language: Английский

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