Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2014, Volume and Issue: 369(1656), P. 20130580 - 20130580

Published: Oct. 14, 2014

The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations fish, discuss potential ecological consequences report results from an experiment which quantify uptake impact a psychiatric drug predatory fish (Perca fluviatilis) its invertebrate prey (Coenagrion hastulatum). We show that perch became more active while damselfly was unaffected, illustrating effects pharmaceuticals can differ between species. Furthermore, demonstrate consumption be exposure route as average 46% pharmaceutical ingested accumulated predator. This suggests investigations through bioconcentration, where trophic interactions subsequent bioaccumulation exposed individuals are ignored, underestimate exposure. Wildlife may therefore to higher levels behaviourally altering than predictions based commonly used assays concentrations found environmental monitoring programmes.

Language: Английский

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Environmental concentrations of the selective serotonin reuptake inhibitor fluoxetine impact specific behaviors involved in reproduction, feeding and predator avoidance in the fish Pimephales promelas (fathead minnow)

Aquatic Toxicology, Journal Year: 2013, Volume and Issue: 151, P. 77 - 83

Published: Oct. 16, 2013

Pharmaceuticals and personal care products (PPCPs) have been found in surface waters worldwide, but little is understood of their effects on the wildlife that inhabit these waters. Fluoxetine (Prozac; Eli Lilly), a highly prescribed selective serotonin reuptake inhibitor (SSRI), commonly PPCP water. The purpose this project was to determine if environmentally relevant concentrations fluoxetine impact behavior important for population survival native fish species, including reproduction, feeding predator avoidance. Chronic 4-week exposures were conducted with doses ranging from 100 ng/L μg/L cover range up higher comparable other published studies same drug documented various physiological impacts. Pimephales promelas (fathead minnow), species North America, used as it conducts specific mating behaviors therefore serves an excellent model impacts brain function. low 1 μg/L, concentration has many freshwater environments, significantly behavior, specifically nest building defending male fish. Males also display aggression, isolation, repetitive at concentrations. Female largely unaffected. In addition, avoidance males females impacted μg/L. Feeding 10 highest exposure (100 μg/L), egg production limited by deaths due significant aggressive first two weeks exposure. Specific behavioral changes occurred each (most noticeably μg/L) indicating dose dependent effect triggered different responses lower versus or differential depending region. Length had behavior. Changes hormone levels, neuroendocrine changes, suggested mechanism response acute studies, not linked study. This research provides detailed data how reproduction are dependent.

Language: Английский

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Human Pharmaceuticals in the Aquatic Environment: A Review of Recent Toxicological Studies and Considerations for Toxicity Testing

Reviews of Environmental Contamination and Toxicology, Journal Year: 2012, Volume and Issue: unknown, P. 1 - 99

Published: Jan. 1, 2012

Language: Английский

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Consumption and ocurrence of antidepressants (SSRIs) in pre- and post-COVID-19 pandemic, their environmental impact and innovative removal methods: A review

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 829, P. 154656 - 154656

Published: March 19, 2022

Language: Английский

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The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

Environmental Science & Technology, Journal Year: 2013, Volume and Issue: 47(20), P. 11384 - 11395

Published: Sept. 5, 2013

Pharmaceuticals in the environment have received increased attention over past decade, as they are ubiquitous rivers and waterways. Concentrations sub-ng to low μg/L, well below acute toxic levels, but there uncertainties regarding effects of chronic exposures is a need prioritise which pharmaceuticals may be concern. The read-across hypothesis stipulates that drug will an effect non-target organisms only if molecular targets such receptors enzymes been conserved, resulting (specific) pharmacological plasma concentrations similar human therapeutic concentrations. If this holds true for different classes pharmaceuticals, it should possible predict potential environmental impact from information obtained during development process. This paper critically reviews evidence read-across, finds few studies include mode action based effects. Thus, despite large number apparently relevant papers general acceptance hypothesis, absence documented evidence. There large-scale generate robust data testing developing predictive models, feasible approach protecting environment.

Language: Английский

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Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows

Environmental Science & Technology, Journal Year: 2012, Volume and Issue: 46(4), P. 2427 - 2435

Published: Jan. 20, 2012

Selective serotonin reuptake inhibitors (SSRIs) represent a class of pharmaceuticals previously reported in aquatic ecosystems. SSRIs are designed to treat depression and other disorders humans, but recognized elicit variety effects on organisms, ranging from neuroendocrine disruption behavioral perturbations. However, an understanding the relationships among mechanistic responses associated with SSRI targets ecologically important fish remains elusive. Herein, linking Adverse Outcomes Pathways (AOP) models internal dosimetry potential approaches for developing pharmaceutical risks life. We selected sertraline as model 28-d study adult male fathead minnows. Binding activity transporter (SERT), demonstrated mammals respond exposure, was endpoint therapeutic activity. Shelter-seeking behavior monitored using digital tracking software diagnose abnormalities. Fish plasma levels exceeding human doses were accurately modeled external exposure concentrations when pH influences ionization log D considered. observed statistically significant decreases binding at target (SERT) shelter-seeking exceeded thresholds. Such observations highlights strengths coupling physiologically based pharmacokinetic modeling AOP suggest that should be advance ecological consequences vertebrates.

Language: Английский

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Uptake and Tissue Distribution of Pharmaceuticals and Personal Care Products in Wild Fish from Treated-Wastewater-Impacted Streams

Environmental Science & Technology, Journal Year: 2015, Volume and Issue: 49(19), P. 11649 - 11658

Published: Sept. 8, 2015

A fish plasma model (FPM) has been proposed as a screening technique to prioritize potential hazardous pharmaceuticals wild fish. However, this approach does not account for inter- or intraspecies variability of pharmacokinetic and pharmacodynamic parameters. The present study elucidated the uptake potency (from ambient water), tissue distribution, biological risk 20 pharmaceutical personal care product (PPCP) residues in cyprinoid inhabiting treated-wastewater-impacted streams. In order clarify uncertainty FPM PPCPs, we compared bioaccumulation factor field (BAFplasma = measured plasma/ambient water concentration ratio) with predicted bioconcentration (BCFplasma by use theoretical partition coefficients/ambient actual environment. As result, maximum BAFplasma inflammatory agents was up 17 times higher than BCFplasma values, leading possible underestimation toxicological on When tissue–blood coefficients (tissue/blood ratios) PPCPs were estimated, transportability into tissues, especially brain, found psychotropic agents, but brain/plasma ratios widely varied among individual (up 28-fold). study, provide valuable data set PPCP pharmacokinetics, our results emphasize importance determining concentrations target organs well blood assess

Language: Английский

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Fish on Prozac (and Zoloft): Ten years later

Aquatic Toxicology, Journal Year: 2014, Volume and Issue: 151, P. 61 - 67

Published: Jan. 19, 2014

Language: Английский

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Current concepts in neuroendocrine disruption

General and Comparative Endocrinology, Journal Year: 2014, Volume and Issue: 203, P. 158 - 173

Published: Feb. 13, 2014

Language: Английский

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Quantitative Cross-Species Extrapolation between Humans and Fish: The Case of the Anti-Depressant Fluoxetine

PLoS ONE, Journal Year: 2014, Volume and Issue: 9(10), P. e110467 - e110467

Published: Oct. 22, 2014

Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, safety assessment environmental toxicology. However, do fish respond to as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) based on hypothesis that similar plasma concentrations cause comparable target-mediated effects both at level biological organization (Read-Across Hypothesis). validate hypothesis, behavioural anti-depressant fluoxetine fathead minnow (Pimephales promelas) were used test case. exposed 28 days range measured water (0.1, 1.0, 8.0, 16, 32, 64 µg/L) produce below, equal above Human Therapeutic Plasma Concentrations (HTPCs). Fluoxetine its metabolite, norfluoxetine, quantified individual linked anxiety-related endpoints. The minimum elicited anxiolytic responses upper value HTPC range, whereas no observed below HTPCs. In vivo metabolism was similar, displayed bi-phasic concentration-dependent kinetics driven by auto-inhibitory dynamics saturation enzymes convert into norfluoxetine. sensitivity not so dissimilar from patients affected general anxiety disorders. These results represent first direct evidence internal dose response effect pharmaceutical fish, hence validating Read-Across applied fluoxetine. Overall, study demonstrates qCSE approach, anchored concentrations, is powerful tool guide pharmaceuticals, strengthens translational power extrapolation.

Language: Английский

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