Metabolites,
Journal Year:
2023,
Volume and Issue:
13(3), P. 461 - 461
Published: March 22, 2023
Fever
represents
an
elevation
of
body
temperature,
that
exerts
a
protective
effect
against
pathogens.
Innate
immune
cells
and
neurons
are
implicated
in
the
regulation
temperature.
Pathogen-associated
molecular
patterns,
i.e.,
lipopolysaccharides
from
Gram-negative
bacteria
peptidoglycan
lipoteichoic
acid
Gram-positive
exogenous
pyrogens,
bind
to
Toll-like
receptors
on
non-immune
cells.
The
subsequent
release
pro-inflammatory
cytokines
[interleukin-1
(IL-1),
IL-6
Tumor
necrosis
factor-alpha]
their
passage
through
brain
trigger
febrile
response.
In
fact,
pre-optic
area
produce
prostaglandin
E2
(PGE2),
that,
turn,
PGE2
receptors;
thus,
generating
fever.
Apart
classical
non-steroidal
anti-inflammatory
drugs,
aspirin
acetaminophen,
various
botanicals
currently
used
as
antipyretic
agents
and,
therefore,
mechanisms
action
will
be
elucidated.
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 13, 2023
Aging
is
a
progressive
and
irreversible
pathophysiological
process
that
manifests
as
the
decline
in
tissue
cellular
functions,
along
with
significant
increase
risk
of
various
aging-related
diseases,
including
metabolic
diseases.
While
advances
modern
medicine
have
significantly
promoted
human
health
extended
lifespan,
diseases
such
obesity
type
2
diabetes
among
older
adults
pose
major
challenge
to
global
public
societies
age.
Therefore,
understanding
complex
interaction
between
factors
crucial
for
promoting
well-being
healthy
aging.
This
review
article
explores
environmental
behavioral
associated
their
impact
on
The
environment,
an
obesogenic
environment
exposure
toxins,
strongly
correlated
rising
prevalence
its
comorbidities.
Behavioral
factors,
diet,
physical
activity,
smoking,
alcohol
consumption,
sleep
patterns,
influence
throughout
Public
interventions
targeting
modifiable
can
effectively
promote
healthier
lifestyles
prevent
Collaboration
government
agencies,
healthcare
providers
community
organizations
essential
implementing
these
creating
supportive
environments
foster
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: March 2, 2023
Physiologically,
the
intestinal
barrier
plays
a
crucial
role
in
homeostasis
and
nutrient
absorption
prevents
pathogenic
entry,
harmful
metabolites,
endotoxin
absorption.
Recent
advances
have
highlighted
association
between
severely
damaged
barriers
diabetes,
obesity,
fatty
liver,
cardiovascular
diseases.
Evidence
indicates
that
an
abated
leads
to
endotoxemia
associated
with
systemic
inflammation,
insulin
resistance,
lipid
accumulation,
accelerating
obesity
liver
Nonetheless,
specific
mechanism
of
damage
effective
improvement
remain
be
explored.
Here,
we
discuss
crosstalk
changes
metabolic
disease.
This
paper
also
highlights
how
improve
gut
from
perspective
natural
medicine,
microbiota
remodeling,
lifestyle
interventions,
bariatric
surgery.
Finally,
potential
challenges
prospects
for
regulation
barrier-metabolic
disease
axis
are
discussed,
which
may
provide
theoretical
guidance
treatment
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(4), P. 833 - 845
Published: Aug. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7062 - 7062
Published: June 27, 2024
In
inflammatory
bowel
diseases
(IBDs),
such
as
Crohn's
disease
(CD)
and
ulcerative
colitis
(UC),
the
immune
system
relentlessly
attacks
intestinal
cells,
causing
recurrent
tissue
damage
over
lifetime
of
patients.
The
etiology
IBD
is
complex
multifactorial,
involving
environmental,
microbiota,
genetic,
immunological
factors
that
alter
molecular
basis
organism.
Among
these,
microbiota
cells
play
pivotal
roles;
generates
antigens
recognized
by
antibodies,
while
autoantibodies
target
attack
membrane,
exacerbating
inflammation
damage.
Given
altered
framework,
analysis
multiple
biomarkers
in
patients
proves
exceedingly
valuable
for
diagnosing
prognosing
IBD,
including
markers
like
C
reactive
protein
fecal
calprotectin.
Upon
detection
classification
patients,
specific
treatments
are
administered,
ranging
from
conventional
drugs
to
new
biological
therapies,
antibodies
neutralize
molecules
tumor
necrosis
factor
(TNF)
integrin.
This
review
delves
into
targets,
biomarkers,
treatment
options,
monitoring
techniques,
and,
ultimately,
current
challenges
management.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2416 - 2416
Published: Oct. 3, 2023
Bacteriophages
(phages)
are
nano-sized
viruses
characterized
by
their
inherent
ability
to
live
off
bacteria.
They
utilize
diverse
mechanisms
absorb
and
gain
entry
into
the
bacterial
cell
wall
via
release
of
viral
genetic
material,
which
uses
replication
host
bacteria
produce
daughter
progeny
virions
that
attack
surrounding
cells.
possess
specific
characteristics,
including
specificity
for
particular
or
closely
related
species.
have
many
applications,
as
potential
alternatives
antibiotics
against
multi-resistant
pathogens
control
agents
in
bacteria-contaminated
environments.
ubiquitously
abundant
nature
biota,
gut.
Gut
microbiota
describes
community
interactions
microorganisms
within
intestine.
As
with
bacteria,
parasitic
bacteriophages
constantly
interact
cells
gut
system
obvious
implications
human
health.
However,
it
is
imperative
understand
these
they
open
up
possible
applicable
techniques
gut-implicated
diseases.
Thus,
this
review
aims
explore
communities
current
impacts
on
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
165, P. 114893 - 114893
Published: June 22, 2023
Gut
microbes
constitute
the
main
microbiota
in
human
body,
which
can
regulate
biological
processes
such
as
immunity,
cell
proliferation,
and
differentiation,
hence
playing
a
specific
function
intestinal
diseases.
In
recent
years,
gut
have
become
research
hotspot
pharmaceutical
field.
Because
of
their
enormous
number,
diversity,
functional
complexity,
essential
functions
development
many
digestive
Inflammatory
bowel
disease
(IBD)
is
chronic
non-specific
inflammatory
with
complex
etiology,
exact
cause
pathogenesis
are
unclear.
There
no
medicines
that
cure
IBD,
more
on
therapeutic
drugs
urgently
needed.
It
has
been
reported
play
critical
role
pathogenesis,
there
tight
association
between
IBD.
The
dysregulation
may
be
predisposing
factor
for
at
same
time,
IBD
exacerbate
microbes'
disorders,
but
mechanism
interaction
two
still
not
well
defined.
study
relationship
only
important
to
elucidate
also
positive
effect
treatment
based
regimen
regulating
microbes.
This
review
describes
latest
progress
provide
reference
assistance
further
research.
theoretical
basis
application
probiotics,
fecal
transplantation,
other
methods
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 20, 2023
There
are
trillions
of
different
microorganisms
in
the
human
digestive
system.
These
gut
microbes
involved
digestion
food
and
its
conversion
into
nutrients
required
by
body.
In
addition,
microbiota
communicates
with
other
parts
body
to
maintain
overall
health.
The
connection
between
brain
is
known
as
gut–brain
axis
(GBA),
involves
connections
via
central
nervous
system
(CNS),
enteric
(ENS),
endocrine
immune
pathways.
regulates
bottom-up
through
GBA,
which
has
prompted
researchers
pay
considerable
attention
potential
pathways
might
play
a
role
prevention
treatment
amyotrophic
lateral
sclerosis
(ALS).
Studies
animal
models
ALS
have
shown
that
dysregulation
ecology
leads
brain–gut
signaling.
This,
turn,
induces
changes
intestinal
barrier,
endotoxemia,
systemic
inflammation,
contribute
development
ALS.
Through
use
antibiotics,
probiotic
supplementation,
phage
therapy,
methods
inducing
can
inhibit
inflammation
delay
neuronal
degeneration,
clinical
symptoms
be
alleviated,
progression
disease
delayed.
Therefore,
may
key
target
for
effective
management
Nutrition Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 16, 2024
Abstract
The
gut
barrier
is
the
first
line
of
defense
against
harmful
substances
and
pathogens
in
intestinal
tract.
balance
proliferation
apoptosis
epithelial
cells
(IECs)
crucial
for
maintaining
integrity
mucosa
its
function.
However,
oxidative
stress
inflammation
can
cause
DNA
damage
abnormal
IECs,
leading
to
disruption
barrier.
This,
turn,
directly
or
indirectly
various
acute
chronic
diseases.
In
recent
years,
there
has
been
a
growing
understanding
vital
role
dietary
ingredients
health.
Studies
have
shown
that
certain
amino
acids,
fibers,
vitamins,
polyphenols
diet
protect
IECs
from
excessive
caused
by
stress,
limit
inflammation.
This
review
aims
describe
molecular
mechanism
relationship
with
function,
discuss
modulation
IECs'
physiological
barrier,
health
nutrients.
findings
this
may
provide
theoretical
basis
use
nutritional
interventions
clinical
disease
research
animal
production,
ultimately
improved
human
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 8, 2024
In
the
advancement
of
Inflammatory
Bowel
Disease
(IBD)
treatment,
existing
therapeutic
methods
exhibit
limitations;
they
do
not
offer
a
complete
cure
for
IBD
and
can
trigger
adverse
side
effects.
Consequently,
exploration
novel
therapies
multifaceted
treatment
strategies
provides
patients
with
broader
range
options.
Within
framework
IBD,
gut
microbiota
plays
pivotal
role
in
disease
onset
through
diverse
mechanisms.
Bacteriophages,
as
natural
microbial
regulators,
demonstrate
remarkable
specificity
by
accurately
identifying
eliminating
specific
pathogens,
thus
holding
promise.
Although
clinical
trials
have
affirmed
safety
phage
therapy,
its
efficacy
is
prone
to
external
influences
during
storage
transport,
which
may
affect
infectivity
regulatory
roles
within
microbiota.
Improving
stability
precise
dosage
control
bacteriophages—ensuring
robustness
consistent
dosing,
targeted
delivery
infection
sites—is
crucial.
This
review
thoroughly
explores
latest
developments
inherent
challenges,
focusing
on
interaction
between
bacteriophages.
It
highlights
bacteriophages’
potential
microbiome
modulators
offering
detailed
insights
into
research
bacteriophage
encapsulation
Particular
attention
paid
functionality
various
carrier
systems,
especially
regarding
their
protective
properties
ability
colon-specific
delivery.
aims
provide
theoretical
foundation
using
bacteriophages
paving
way
enhanced
regulation
intestinal
