Human Reproduction Update,
Journal Year:
2022,
Volume and Issue:
29(2), P. 177 - 196
Published: Nov. 14, 2022
In
2020,
SARS-CoV-2
and
the
COVID-19
pandemic
had
a
huge
impact
on
access
to
provision
of
ART
treatments.
Gradually,
knowledge
virus
its
transmission
has
become
available,
allowing
activities
resume.
Still,
questions
human
gametes
fertility
remain.
BMJ Sexual & Reproductive Health,
Journal Year:
2024,
Volume and Issue:
50(3), P. 212 - 225
Published: June 10, 2024
Menstrual
health
is
a
key
patient-reported
outcome
beyond
its
importance
as
general
indicator
of
and
fertility.
However,
menstrual
function
was
not
measured
in
the
clinical
trials
COVID-19
vaccines.
The
purpose
this
review
to
synthesise
existing
literature
on
relationship
between
vaccination
outcomes.
International Journal of Clinical Practice,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 5
Published: Oct. 27, 2022
Several
factors
such
as
stress,
depression,
infection,
and
vaccination
influenced
the
menstrual
cycle
in
women
during
coronavirus
disease
2019
(COVID-19)
pandemic.
We
investigated
whether
there
were
changes
after
COVID-19
or
infection
and,
if
so,
nature
of
change.This
study
was
designed
a
descriptive,
cross-sectional
study.
A
face-to-face
survey
conducted
among
menstruating
aged
18-50
years
from
May
31
to
July
31,
2022.
Women
inquired
about
their
first
three
cycles
that
occurred
vaccination.Of
241
with
86
(35.7%)
mentioned
they
experienced
various
patterns
infection.
Of
537
participants
who
received
vaccines,
82
(15.1%)
stated
vaccination.
The
incidence
postvaccination
change
higher
Pfizer-BioNTech
Sinovac
(CoronaVac)
vaccines.
Only
10.9%
reported
pattern
consulted
physician.COVID-19
can
affect
women.
It
is
important
be
aware
warn
inform
this
issue.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(5), P. e0320162 - e0320162
Published: May 16, 2025
The
relationship
between
COVID-19
vaccines
and
menstrual
disturbance
is
unclear,
in
part
because
researchers
have
measured
different
outcomes
(e.g.,
delays
vs.
changes
to
cycle
length)
with
various
study
designs.
Menstrual
disruption
could
be
a
decisive
factor
people's
willingness
accept
the
vaccine.
We
searched
Medline,
Embase,
Web
of
Science
for
studies
investigating
length,
flow
volume,
post-menopausal
bleeding,
unexpected
or
intermenstrual
bleeding.
Data
were
analyzed
using
fixed-effects
meta-analysis
Shore's
adjusted
confidence
intervals
heterogeneity.
Seventeen
>1·9
million
participants
analyzed.
found
19%
greater
risk
increase
length
as
compared
unvaccinated
people
pre-vaccination
time-periods
(summary
relative
(sRR):
1·19;
95%
CI:
1·11-1·26;
n
=
23,718
participants).
was
same
Pfizer-BioNTech
(sRR:
1·15;
1·05-1·27;
16,595)
Moderna
1·05-1·25;
7,523),
similar
AstraZeneca
1·27;
1·02-1·59;
532),
higher
Janssen
1·69;
1·14-2·52;
751)
In
first
after
vaccination,
increased
by
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(15), P. 4991 - 4991
Published: July 29, 2023
The
COVID-19
pandemic
has
become
the
largest
and
most
diverse
to
threaten
health
of
humanity
since
1918
influenza
pandemic.This
study
involved
113
women
who
had
suffered
from
COVID-19.
was
conducted
as
interviews
with
each
woman
during
visits
a
clinic
prior
start
their
post-COVID-19
physiotherapy
treatment
cycle.
aim
this
assess
prevalence
changes
in
women's
monthly
cycles
related
COVID-19,
well
analyse
correlations
between
dependent
variables
relating
cycle
independent
other
factors,
such
age,
weight,
number
type
vaccinations,
time
illness.
Additionally,
assesses
symptoms
persisting
after
illness
(long
COVID).Women
reported
more
were
likely
report
menstrual
occurring
SARS-CoV-2
infection,
compared
whose
disease
course
mild.
Women
declared
that
affected
often
indicated
increases
abdominal,
lower
joint
muscle
pain,
severity
headaches
bleeding.
A
small
percentage
longer
regularity
disrupted.This
shows
had,
there
noted
same
relationship
also
found
for
persistent
long
COVID
symptoms.
lapse
less
frequently
recorded.
Medicine,
Journal Year:
2025,
Volume and Issue:
104(8), P. e41656 - e41656
Published: Feb. 21, 2025
Data
supporting
the
evidence
of
changes
in
menstrual
cycle
and
premenstrual
symptoms
associated
with
coronavirus
disease
(COVID-19)
is
quite
scarce.
To
determine
association
between
COVID-19
vaccination
its
relationship
different
types
vaccines
among
women
reproductive
age
Abha
City,
Saudi
Arabia.
A
cross-sectional
study
was
conducted
from
January
2022
to
June
2022,
participants
Asser
region
Arabia
by
using
a
self-administered
questionnaire
through
an
electronic
survey.
analysis
performed
SPSS
version
16.0.
Among
1208
subjects,
majority
(66.9%)
females
had
menarche
at
<13
years,
17.2%
irregular
periods,
24.8%
reported
average
regularity
periods
(23–35
days).
statistically
significant
found
who
experienced
change
their
after
receiving
vaccine.
Mood
swings
lower
back
pain
were
common
syndrome
symptoms.
Only
15%
delay
conception.
Out
176
females,
40%
showed
6
month
conception
Multivariate
logistic
regression
that
age,
usual
volume
bleeding
significantly
vaccination.
The
vaccine
on
established
our
study.
Further
research
needed
produce
concrete
regarding
eliminate
hesitancy
women.
Human Reproduction,
Journal Year:
2023,
Volume and Issue:
38(9), P. 1825 - 1834
Published: July 12, 2023
Are
there
some
characteristics
that
render
individuals
more
susceptible
to
report
menstrual
changes
following
the
Coronavirus
disease
2019
(COVID-19)
vaccination?We
found
30%
of
menstruating
women
reported
COVID-19
vaccination
and
several
potential
risk
factors
including
stress,
vaccine
concerns,
severe
infection,
immediate
symptoms
were
associated
with
these
reports.Studies
suggest
might
temporarily
prolong
cycle
length
by
less
than
1
day.
Specific
may
trigger
in
temporal
relation
simply
chance
or
vigilant
after
being
vaccinated.
However,
research
investigating
for
reporting
is
limited.A
population-based
Danish
cohort
study.
Data
collected
from
May
2021
December
as
a
part
BiCoVac
Cohort
aim
examining
non-specific
effects
vaccination.
The
main
study
population
included
13
648
aged
16-65
years
who
completed
all
surveys,
received
their
first
dose
during
data
collection
period,
questions
related
cycle.Potential
14
biological,
physical,
psychological
measures.
Information
on
most
was
self-reported
before
participants'
about
any
change
at
end
period.
Logistic
regression
analyses
used
estimate
crude
adjusted
odds
ratios
(ORs)
95%
CIs
association
between
each
factor
vaccination.Any
women.
Most
reports
In
particular,
higher
among
≥5
symptoms;
OR
1.67
[1.50-1.86],
had
prior
infection;
2.17
[1.40-3.35],
high-stress
level
baseline;
[1.32-2.10],
concerned
vaccines
vaccination;
1.92
[1.50-2.45].
Lower
regular
cycles
using
hormonal
contraception;
0.71
[0.65-0.78].We
unable
address
causal
effect
changes,
information
not
available
non-vaccinated
women.The
identified
Further
studies
are
needed
establish
associations
clinical
impact
changes.The
funded
TrygFonden
(id-number:
153678).
No
competing
interests
declared.N/A.
Pharmacoepidemiology and Drug Safety,
Journal Year:
2024,
Volume and Issue:
33(8)
Published: Aug. 1, 2024
ABSTRACT
Background
Reports
of
adverse
menstrual
events
emerged
during
the
COVID‐19
vaccination
campaign
in
multiple
countries.
This
raised
question
whether
these
reports
were
caused
by
vaccines.
The
aim
this
systematic
review
was
to
evaluate
comparative
studies
on
topic
(registered
at
PROSPERO
[CRD42022324973]).
Methods
We
included
observational
such
as
cohort
and
surveys
comparing
response
self‐reported
questionnaires
between
post‐
versus
pre‐vaccination
data.
PubMed
Cochrane
Library
searches
conducted
1
September
2023.
primary
outcome
incidence
any
prespecified
event,
measure
risk
ratio.
meta‐analysis
using
Mantel–Haenszel
method
random
effects
model.
summarized
results
factors
well
key
findings
included.
Results
retrieved
161
references
from
electronic
databases
additional
sources
lists.
Of
those,
we
considered
21
studies.
event
reported
12
resulted
a
pooled
estimate
(risk
ratio
1.13;
95%
CI,
0.96–1.31)
that
did
not
favor
group.
analysis
constrained
considerable
clinical
statistical
heterogeneity.
Risk
for
changes
history
infection,
concern
about
vaccines,
smoking,
previous
cycle
irregularities,
depression,
stress,
other
issues.
Conclusions
group
heterogeneity
prevalent
among
Most
suggested
temporary,
minor,
nonserious.
Saudi Pharmaceutical Journal,
Journal Year:
2023,
Volume and Issue:
31(5), P. 746 - 751
Published: March 31, 2023
Recently,
few
studies
have
mentioned
minor
changes
in
women's
menstrual
cycle
after
the
COVID-19
vaccination.
There
were
many
reported
cases
of
female
problems
primary
healthcare
clinics
Riyadh,
Saudi
Arabia.
The
study
aimed
to
explore
prevalence
irregularities
vaccine
among
females
childbearing
age
Arabia.This
observational
cross-sectional
was
conducted
from
dec
2021
June
2022
carried
out
by
using
a
convenience
sampling
technique.Our
analysis
includes
1066
participants.
Abnormal
menstruation
significantly
associated
with
hypertension
(p-value
=
0.024),
polycystic
ovary
syndrome
0.001),
and
at
least
one
gynaecological
condition
<
0.001).
However,
multivariate
regression
showed
that
abnormality
before
receiving
(OR
0.09,
95%
CI,
0.06
0.14,
p-value
0.001)
more
likely
be
abnormal
vaccine.Our
findings
significant
association
between
covid-19
vaccination
irregularity
administering
vaccine,
irrespective
type
or
number
doses
administered.
Future
ongoing
clinical
trials
should
investigate
abnormalities,
other
vaginal
bleeding
hormonal
post-vaccination,
especially
vaccine.
