Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106770 - 106770
Published: March 29, 2025
Language: Английский
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 28, 2025
IgA nephropathy (IgAN) is related to the balance of gut microbiota. However, it unclear whether changes in microbiota can cause IgAN or attenuate its progression. This study employed and human microbiota-associated (HMA)-IgAN models investigate impact on alteration mechanisms by which might trigger IgAN. Furthermore, this examined effects chitooligosaccharides (COS) COS formulation (COSF) with microbiota-targeting function enhancing intestinal barrier renal functions. These results revealed that led a reduction α-diversity structural alterations microbiota, characterized an increase Shigella sonnei, Streptococcus danieliae, Desulfovibrio fairfieldensis, decrease Bifidobacterium pseudolongum Clostridium leptum. There was also imbalance B-cell immunity level tight junction proteins (ZO-1 Occludin). Intestinal mucosal immune-related (Clostridium leptum, unclassified Lachnospiraceae NK4Al36 group, Clostridia vadinBB60 Oscillospiraceae, Roseburia) were enriched through targeted modulation COS/COSF, ZO-1 expression reducing APRIL/BAFF overexpression, thereby damage In conclusion, clarified kidney-gut crosstalk between IgAN, providing scientific evidence for developing microbiota-targeted food interventions improve outcomes.
Language: Английский
Citations
2
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 26, 2025
Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.
Language: Английский
Citations
2
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 5, 2024
Abstract Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing CKD. Here, using microbiomics 480 participants including healthy controls and patients stage 1–5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae- Lactobacillus - johnsonii correlated CKD progression, whose abundance strongly clinical markers. L. reduced rats adenine-induced supplementation ameliorated lesion. Serum indole-3-aldehyde (IAld), level negatively creatinine rats, decreased serum of induced unilateral ureteral obstruction (UUO) 5/6 nephrectomy (NX) as well late patients. Treatment IAld dampened lesion through aryl hydrocarbon receptor (AHR) signal or UUO, cultured 1-hydroxypyrene-induced HK-2 cells. Renoprotective effect was partially diminished AHR deficiency mice Our further data showed treatment attenuated by via increasing level. Taken together, targeting might reverse This study provides a deeper understanding how microbial-produced tryptophan metabolism affects host discovers potential pathways for prophylactic therapeutic treatments
Language: Английский
Citations
14
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 16, 2024
Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney injury (AKI) and chronic disease (CKD) both result in renal fibrosis. Oxidative stress inflammation play central roles progressive are closely linked form vicious cycle which oxidative induces through various molecular mechanisms. Ample evidence has indicated that hyperactive nuclear factor kappa B (NF-ƙB) signaling pathway plays pivotal role Hyperactive NF-ƙB causes the activation recruitment of immune cells. Inflammation, turn, triggers production reactive oxygen species nitrogen by activating leukocytes resident These events mediate organ apoptosis, necrosis, Therefore, developing strategy to target important for effective treatment This Review summarizes effect on context AKI CKD (immunoglobulin A nephropathy, membranous diabetic hypertensive transplantation). Therapies targeting pathway, including natural products, also discussed. In addition, NF-ƙB-dependent non-coding RNAs involved crucial targets development treatments disease. provides clear pathophysiological rationale specific concept-driven therapeutic pathway.
Language: Английский
Citations
12
Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 325 - 325
Published: Jan. 17, 2025
Background/Objectives: A fucoidan oligosaccharide (FOS), a potent compound derived from algae, is known for its diverse biological activities, including prebiotic activity, anticancer and antioxidative properties, has demonstrated supportive therapeutic effects in treating kidney ailments. This study was conducted to explore the protective influence of FOS on damage due aging induced by D-galactose Sprague Dawley (SD) rats. Methods: The low-dose group administered (100 mg/kg) gavage, high-FOS received (200 gavage. Results: findings showed that could effectively mitigate improve pathological condition tissues caused D-gal enhance function. Intervention with significantly reduced serum creatinine, uric acid, urea nitrogen levels, compared model group. mechanism D-gal-induced injury may be inhibit oxidative stress impaired mitochondrial function downregulating AMPK/ULK1 signaling pathway. also modulate expression autophagy-related proteins (Beclin-1, P62, LC3II/LC3I), thereby excessive mitophagy kidney. Furthermore, protect against preserving intestinal homeostasis. decreased lipopolysaccharide levels enhanced mucosal barrier upregulated abundances Bacteroidota, Muribaculaceae, Lactobacillus, while it Firmicutes, NK4A136_group, Lachnospiraceae_NK4A136_group. supplementation modulated gut microbiota composition, increasing beneficial bacteria reducing detrimental ones, potentially contributing improved Conclusions: safeguard renal D-gal-exposed rats inhibiting mitophagy, function, regulating
Language: Английский
Citations
1
Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 31, 2024
Language: Английский
Citations
8
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 225, P. 116313 - 116313
Published: May 22, 2024
Language: Английский
Citations
7
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3013 - 3029
Published: May 1, 2024
Purpose: Neonatal Acute Respiratory Distress Syndrome (NARDS) is a severe respiratory crisis threatening neonatal life.We aim to identify changes in the lung-gut microbiota and lung-plasma tryptophan metabolites NARDS neonates provide differentiated tool aid finding potential therapeutic targets.Patients Methods: Lower secretions, faeces plasma were collected from 50 including 25 patients (10 with mild NARDS_M group 15 moderate-to-severe NARDS_S group) control screened based on gestational age, postnatal age birth weight.Lower airway secretions feces underwent 16S rRNA gene sequencing understand microbial communities lung gut, while lower LC-MS analysis blood.Correlation analyses performed by comparing differences between control, groups.Results: Significant gut as well observed compared controls.Proteobacteria Bacteroidota increased lungs of neonates, whereas Firmicutes, Streptococcus, Rothia reduced.Lactobacillus decreased neonates.Indole-3-carboxaldehyde levels 3-hydroxykynurenine, indoleacetic acid, indolelactic 3-indole propionic indoxyl sulfate, kynurenine, neonates.Altered was significantly related metabolites, having better ability for diagnosis grading plasma.Conclusion: occurred neonates.Alterations discriminatory NARDS.
Language: Английский
Citations
5
iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109132 - 109132
Published: Feb. 6, 2024
Chronic kidney disease (CKD) is a major public health burden, with dietary acid load (DAL) and gut microbiota playing crucial roles. As DAL can affect the host metabolome, potentially via microbiota, we cross-sectionally investigated interplay between DAL, early-stage CKD (TwinsUK, n = 1,453). was positively associated stage G1-G2 (Beta (95% confidence interval) 0.34 (0.007; 0.7), p 0.046). After adjusting for covariates multiple testing, identified 15 serum, 14 urine, 8 stool, 7 saliva metabolites, primarily lipids amino acids, both progression. Of these, 2 one stool metabolites were found to mediate DAL-CKD association. Furthermore, metabolite 5-methylhexanoate (i7:0) correlated 26 microbial species. Our findings emphasize microbiota's therapeutic potential in countering DAL's impact on through metabolome. Interventional longitudinal studies are needed establish causality.
Language: Английский
Citations
4
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Feb. 3, 2025
Abstract Background NUAK1 is associated with metastasis and drug resistance in hepatocellular carcinoma (HCC). However, little known about the immune functions of HCC. Therefore, aim this study was to elucidate novel role facilitating evasion HCC investigate mechanisms underpinning process. Method The levels expression infiltration CD8 + T cells were assessed tumor tissues from patients mice xenograft model. cell lines used validate regulating transcription PD-L1, diethylnitrosamine-induced model established PD-L1 proteins rat livers detected. Western blotting, immunofluorescence, real time PCR, immunohistochemical staining underlying by which regulates carcinoma. Results negatively correlated Both gain loss have identified promoted at transcriptional level cells. increased observed Moreover, overexpression promotes GSK3β Ser 9 phosphorylation, β-catenin nuclear accumulation By contrast, knockdown has opposite effects. Inhibition activity significantly IHC analyses suggested that p-GSK3β positively expression. Knockdown also reversed NUAK1-mediated Conclusions This revealed a for NUAK1, activating GSK3β/β-catenin signaling pathway, leading escape Registry registration no. study/trial : Not applicable.
Language: Английский
Citations
0