Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis DOI Open Access
Daniela Balderas-Cordero, Octavio Canales-Álvarez, Roberto Sánchez‐Sánchez

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11831 - 11831

Published: July 23, 2023

Skin wound healing is a complex biochemical process of tissue repair and remodeling in response to injury. Currently, the drugs used improve are inaccessible population, costly, have side effects, making search for new treatment alternatives necessary. Propolis natural product produced by bees that widely recognized folk medicine its multiple biomedical activities. However, therapeutic information regarding Mexican propolis limited. This study aimed evaluate wound-healing effect Chihuahua ethanolic extract (ChEEP). Macroscopic histological analyses were performed using mouse model. The topic acute toxicity assay showed at 10% w/v had no toxic effects. ChEEP has antibacterial activity against Gram-positive bacteria Staphylococcus aureus epidermidis. Moreover, it exhibited good anti-inflammatory evaluated through ear edema induced 12-O-tetradeca-noylphorbol-13-acetate (TPA). A full-thickness incision lesion was created mice treated topically with ChEEP. At Day 14 post-treatment, observed increased contraction reduced time length; furthermore, tensile strength wound, as determined tensiometric method, promoted formation type I collagen site injury, Herovici stain. These findings suggest topical administration can skin healing, probably due synergistic components, mainly polyphenols, different steps process. It should be noted this first been evaluated.

Language: Английский

Coaxial electrospun angiogenic nanofiber wound dressing containing advanced platelet rich-fibrin DOI
Mohamadreza Tavakoli, Marjan Mirhaj,

Saeideh Salehi

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 222, P. 1605 - 1618

Published: Sept. 15, 2022

Language: Английский

Citations

47
PDGF and VEGF-releasing bi-layer wound dressing made of sodium tripolyphosphate crosslinked gelatin-sponge layer and a carrageenan nanofiber layer DOI

Mansoor Alizadeh,

Saeideh Salehi,

Mohamadreza Tavakoli

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123491 - 123491

Published: Feb. 1, 2023

Language: Английский

Citations

34
Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix DOI Creative Commons
Yasaman Esmaeili, Elham Bidram, Ashkan Bigham

et al.

Alexandria Engineering Journal, Journal Year: 2023, Volume and Issue: 81, P. 137 - 169

Published: Sept. 14, 2023

The advancement of tissue engineering for regenerating injured tissues and organs has progressed significantly in recent years. Various techniques have been used to modify the cells' microenvironments targeted via their extracellular environment achieving these aims. 3D structured scaffolds alone or combined with bioactive molecules genes cells hold great promise development functional engineered tissues. As an emerging state-of-the-art technology this field, integrating gene therapy, known as gene-activated matrix (GAM), gained immense attention a promising approach restoring damaged dysfunctional tissues' function structure. Nonetheless, fabricating GAMs low cytotoxicity, high transfection efficiency, long-term delivery efficiency is still challenging. Here we provide complete overview different approaches ongoing preclinical research trials. Moreover, GAM strategy focus on development, faithful application, future prospects repair regeneration replacement assayed. challenges regenerative medicine are also presented. Eventually, propose that offer basic mechanistic infrastructure "tissue engineering" pave way clinical translation achieve personalized medicine.

Language: Английский

Citations

32
Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products DOI Creative Commons
Archita Sharma, Dhavan Sharma, Feng Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: June 12, 2023

Impaired wound healing after trauma, disorders, and surgeries impact millions of people globally every year. Dysregulation in orchestrated mechanisms underlying medical complications make chronic management extremely challenging. Besides standard-of-care treatments including broad spectrum antibiotics wound-debridement, novel adjuvant therapies are clinically tested commercialized. These include topical agents, skin substitutes, growth factor delivery, stem cell therapies. With a goal to overcome factors playing pivotal role delayed healing, researchers exploring approaches elicit desirable outcomes wounds. Although recent innovations care products, therapies, devices extensively reviewed past, comprehensive review summarizing their clinical is surprisingly lacking. Herein, this work reviews the commercially available products performance trials provide statistically understanding safety efficacy. The suitability various commercial platforms, xenogeneic allogenic devices, biomaterials, discussed for current evaluation will benefits drawbacks most-recent enable healthcare providers develop next-generation technologies management.

Language: Английский

Citations

26
Photobiomodulation with Blue Light on Wound Healing: A Scoping Review DOI Creative Commons
Thaís Paulino do Prado, Flávia Cristina Zanchetta, Beatriz Barbieri

et al.

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 575 - 575

Published: Feb. 18, 2023

Photobiomodulation consists of inducing healing by irradiating light. This scoping review investigates the effect blue light on process.

Language: Английский

Citations

24
A multifunctional injectable hydrogel for boosted diabetic wound healing assisted by Quercetin-ZIF system DOI

Jinglei Gong,

Hao Wang,

Chaoming Xie

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153425 - 153425

Published: June 22, 2024

Language: Английский

Citations

15
Renewable biomass-based aerogels: from structural design to functional regulation DOI
Linfeng Chen, Xiaoxiao Yu, Mengyue Gao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(14), P. 7489 - 7530

Published: Jan. 1, 2024

Global population growth and industrialization have exacerbated the nonrenewable energy crises environmental issues, thereby stimulating an enormous demand for producing environmentally friendly materials. Typically, biomass-based aerogels (BAs), which are mainly composed of biomass materials, show great application prospects in various fields because their exceptional properties such as biocompatibility, degradability, renewability. To improve performance BAs to meet usage requirements different scenarios, a large number innovative works past few decades emphasized importance micro-structural design regulating macroscopic functions. Inspired by ubiquitous random or regularly arranged structures materials nature ranging from micro meso macro scales, constructing microstructures often corresponds completely functions even with similar biomolecular compositions. This review focuses on preparation process, concepts, regulation methods, synergistic combination chemical compositions porous perspective gel skeleton pore structure. It not only comprehensively introduces effect physical BAs, but also analyzes potential applications corresponding thermal management, water treatment, atmospheric harvesting, CO

Language: Английский

Citations

12
Stimuli-responsive chitosan-based nanocarriers for drug delivery in wound dressing applications: A review DOI Creative Commons
Seyed Morteza Naghib, Saba Amiri, M. R. Mozafari

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100497 - 100497

Published: April 6, 2024

Wound care poses a significant global challenge, imposing substantial financial strain on governments across the globe. The exploration of wound dressings (WDs) with potential to enhance healing process has been subject extensive research and scrutiny for an extended period. Traditional dressings, such as bandages, hydrogels, foams, fall short achieving desired (WH) outcomes due their limited ability accurately address dynamic tissue repair. There have suggestions create sophisticated WDs capability interact wounds, perceive alterations in wound's state or surroundings, react correspondingly. This proposal encompasses development advanced that possess interactive features improved monitoring response changes conditions. These innovative incorporate sensors intelligent materials stimuli-responsive self-healing materials, aiming effectively WH. In recent years, there advancement field WDs, introduction smart WDs. cutting-edge include biomechanical mobile injuries, self-removable progressive technology showcases revolutionize management treatment various types wounds. review aims provide overview chitosan nanoparticles (CS NPs) exhibit responsiveness stimuli. article discusses aspects these focusing characteristics applications scientific scholarly manner.

Language: Английский

Citations

11
Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin DOI Creative Commons

Sol Youn,

Mi‐Ran Ki, Mohamed Abdel‐Hamid

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(5), P. 278 - 278

Published: May 7, 2024

Biomimetic materials have become a promising alternative in the field of tissue engineering and regenerative medicine to address critical challenges wound healing skin regeneration. Skin-mimetic enormous potential improve outcomes enable innovative diagnostic sensor applications. Human skin, with its complex structure diverse functions, serves as an excellent model for designing biomaterials. Creating effective coverings requires mimicking unique extracellular matrix composition, mechanical properties, biochemical cues. Additionally, integrating electronic functionality into these presents exciting possibilities real-time monitoring, diagnostics, personalized healthcare. This review examines biomimetic their role healing, well integration technologies. It discusses recent advances, challenges, future directions this rapidly evolving field.

Language: Английский

Citations

11
Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies DOI
Fen Wang, Xiaoling Zhang, Jing Zhang

et al.

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(4), P. 1501 - 1544

Published: Jan. 27, 2024

Diabetic foot ulcer (DFU) is one of the most costly and serious complications diabetes. Treatment DFU usually challenging new approaches are required to improve therapeutic efficiencies. This review aims update upcoming adjunctive therapies with noninvasive characterization for DFU, focusing on bioactive dressings, bioengineered tissues, mesenchymal stem cell (MSC) based therapy, platelet cytokine-based topical oxygen some repurposed drugs such as hypoglycemic agents, blood pressure medications, phenytoin, vitamins, magnesium. Although mentioned may contribute improvement a certain extent, evidence come from clinical trials small sample size inconsistent selections patients. Further studies high design quality adequate sizes necessitated. In addition, no single approach would completely correct complex pathogenesis DFU. Reasonable selection combination these techniques should be considered.

Language: Английский

Citations

8