Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135692 - 135692
Published: March 9, 2022
Language: Английский
Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(6), P. 1375 - 1413
Published: Sept. 16, 2022
Abstract Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. We first introduce the construction of fiber scaffolds their various structures, as well commonly used types drugs. Then, we discuss some representative controlling by fibers, with specific emphasis on design endogenous external stimuli-responsive systems. Afterwards, summarize recent progress engineering, including soft engineering (such skin, nerve, cardiac repair) hard bone, cartilage, musculoskeletal systems), Furthermore, provide future development directions challenges facing use fibers controlled delivery, aiming insights perspectives smart platforms improve clinical therapeutic effects in Graphical abstract
Language: Английский
Citations
100
Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)
Published: Aug. 23, 2023
The development of self-healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical materials such as polypyrrole (PPy) are commonly used to fabricate artificial conduits. Moreover, the field engineering has advanced toward use products hyaluronic acid (HA) hydrogels. Although HA-modified PPy films prepared for various biological applications, cell-matrix interaction mechanisms remain poorly understood; furthermore, there no reports on PPy-injectable peripheral repair. Therefore, this study, a electroconductive hydrogel (HASPy) from HA, cystamine (Cys), and pyrrole-1-propionic (Py-COOH), with injectability, biodegradability, biocompatibility, nerve-regenerative capacity constructed. directly targets interleukin 17 receptor A (IL-17RA) promotes expression genes proteins relevant Schwann cell myelination mainly by activating (IL-17) signaling pathway. injected into rat sciatic nerve-crush injury sites investigate its regeneration vivo found promote functional recovery remyelination. This study may help understanding mechanism interactions provide new insights potential HASPy an scaffold neural regeneration.
Language: Английский
Citations
53
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: Feb. 18, 2024
Abstract Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores potential targeted modulation mechanical cues enhance regeneration, promoting scarless repair by influencing extracellular microenvironment driving phenotypic transitions. The field appendage regeneration has witnessed remarkable advancements in utilization biomaterials with distinct physical properties. However, a comprehensive understanding underlying mechanisms remains somewhat elusive, limiting broader application these innovations. In this review, we present two promising biomaterial-based approaches aimed at bolstering regenerative capacity compromised skin. first approach involves leveraging specific biophysical properties create an optimal environment that supports cellular activities essential for regeneration. second centers on harnessing forces exerted plasticity, facilitating efficient reprogramming and, consequently, appendages. summary, manipulation using strategies holds significant promise as supplementary achieving wound healing, coupled restoration multiple functions.
Language: Английский
Citations
17
Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(41)
Published: Aug. 5, 2022
Abstract In recent decades, artificial nerve scaffolds have become a promising substitute for peripheral repair. Considerable efforts been devoted to improving the therapeutic effectiveness of scaffolds. Among numerous biomaterials tissue engineering fabrication, natural polymers are considered as tremendous candidates because their excellent biocompatibility, low toxicity, high cell affinity, wide source, and environmental protection. With development technology, variety polymer‐derived emerged, which endowed with biological properties appropriate physicochemical performances gradually adapt needs regeneration. Significantly, intergradation exogenous biomolecules onto is able avoid stability, rapid degradation, redistribution direct drugs in vivo, thereby enhancing regeneration functional reconstruction. Here, derived from polymers, applications continuous administration comprehensively carefully reviewed, providing an advanced perspective field.
Language: Английский
Citations
56
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Oct. 28, 2022
Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity internal-facing longitudinal grooves explore its function in SCI repair. It is found that resultant grooved could effectively promote neural stem cells (NSCs) adhesion, directed proliferation differentiation vitro. Additionally, when loaded NSCs (GMN) implanted into site, effective repair capability for complete transection was demonstrated. The GMN group shows remarkable recovery significantly higher BBB scores comparison to other groups. Therefore, microgroove structure promising strategy treating SCI.
Language: Английский
Citations
52
Engineered Regeneration, Journal Year: 2022, Volume and Issue: 3(2), P. 154 - 162
Published: April 26, 2022
Nervous system injuries remain a great challenge due to limited natural tissue regeneration capabilities. Neural engineering has been regarded as promising approach for repairing nerve defects, which utilizes external biomaterial scaffolds allow cells migrate the injury site and repair tissue. Particularly, with anisotropic structures biomimicking native extracellular matrix (ECM) can effectively guide neural orientation reconnection. Here, advancements of in field are presented. The fabrication strategies their effects vitro vivo highlighted. We also discuss challenges provide perspective this field.
Language: Английский
Citations
46
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(1)
Published: Oct. 2, 2022
Clinical wound management of radiation-induced skin injury (RSI) remains a great challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and the concomitant repetitive inflammatory microenvironment caused an imbalance in macrophage homeostasis. Herein, cutaneous extracellular matrix (ECM)-inspired glycopeptide hydrogel (GK@TAgel ) is rationally designed for accelerating healing through modulating chronic inflammation RSI. The not only replicates ECM-like glycoprotein components nanofibrous architecture, but also displays effective ROS scavenging radioprotective capability that can reduce after exposure irradiation. Importantly, mannose receptor (MR) GK@TAgel exhibits high affinity bioactivity drive M2 polarization, thereby overcoming persistent repair RSI mice demonstrates significantly reduces hyperplasia epithelial, promotes appendage regeneration angiogenesis, decreased proinflammatory cytokine expression, which superior treatment commercial drug amifostine. Collectively, ECM-mimetic dressing protect tissue from irradiation heal RSI, holding potential clinical regeneration.
Language: Английский
Citations
41
Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100668 - 100668
Published: May 19, 2023
Peripheral nerve injury (PNI) is a complex disease that often appears in young adults. It characterized by high incidence, limited treatment options, and poor clinical outcomes. This not only causes dysfunction psychological disorders patients but also brings heavy burden to the society. Currently, autologous grafting gold standard treatment, complications, such as source of donor tissue scar formation, further limit therapeutic effect. Recently, growing number studies have used tissue-engineered materials create natural microenvironment similar nervous system thus promote regeneration neural recovery impaired function with promising results. Hydrogels are for culture differentiation neurogenic cells due their unique physical chemical properties. can provide three-dimensional hydration networks be integrated into variety sizes shapes suit morphology tissues. In this review, we discuss recent advances engineered hydrogels peripheral repair analyze role several different strategies PNI through application characteristics engineering (NTE). Furthermore, prospects challenges discussed.
Language: Английский
Citations
38
Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 227 - 242
Published: May 30, 2023
Biomaterials can modulate the local immune and repair-supportive microenvironments to promote peripheral nerve regeneration. Inorganic bioceramics have been widely used for regulating tissue regeneration response. However, little is known on whether inorganic potential enhancing what are mechanisms underlying their actions. Here, lithium-magnesium-silicon (Li-Mg-Si, LMS) containing scaffolds fabricated characterized. The LMS-containing had no cytotoxicity against rat Schwann cells (SCs), but promoted migration differentiation towards a remyelination state by up-regulating expression of neurotrophic factors in β-catenin-dependent manner. Furthermore, using single cell-sequencing, we showed that macrophage polarization pro-regenerative M2-like cells, which subsequently facilitated SCs. Moreover, implantation with guidance conduits (NGCs) increased frequency infiltration enhanced motor functional recovery model sciatic injury. Collectively, these findings indicated LMS offered strategy modulating microenvironment promoting SCs remyelination.
Language: Английский
Citations
33
Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 370 - 386
Published: March 16, 2023
Autologous nerve grafting serves is considered the gold standard treatment for peripheral defects; however, limited availability and donor area destruction restrict its widespread clinical application. Although performance of allogeneic decellularized implants has been explored, challenges such as insufficient human donors have a major drawback to use. Tissue-engineered neural regeneration materials developed over years, researchers explored strategies mimic microenvironment during design catheter grafts, namely extracellular matrix (ECM), which includes mechanical, physical, biochemical signals that support regeneration. In this study, polycaprolactone/silk fibroin (PCL/SF)-aligned electrospun material was modified with ECM derived from umbilical cord mesenchymal stem cells (hUMSCs), dual-bionic successfully fabricated. The results indicated biomimetic had excellent biological properties, providing sufficient anchorage Schwann subsequent axon angiogenesis processes. Moreover, exerted similar effect autologous transplantation in bridging defects rats. conclusion, study provides new concept designing materials, prepared repair auxiliary regenerative ability further preclinical testing warranted evaluate application potential.
Language: Английский
Citations
23