Towards microbial consortia in fermented foods for metabolic engineering and synthetic biology DOI
Yongping Xin, Mingqiang Qiao

Food Research International, Journal Year: 2025, Volume and Issue: 201, P. 115677 - 115677

Published: Jan. 5, 2025

Language: Английский

Engineered microbial consortia: strategies and applications DOI Creative Commons
Katherine E. Duncker, Zachary A. Holmes, Lingchong You

et al.

Microbial Cell Factories, Journal Year: 2021, Volume and Issue: 20(1)

Published: Nov. 16, 2021

Abstract Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks single populations can be a challenge because large genetic circuits burdensome difficult to optimize. To overcome these limitations, consortia engineered distribute among multiple populations. Recent studies have made substantial progress programming for both basic understanding potential applications. Microbial been designed through diverse strategies, including mutualistic interactions, using programmed population control prevent overgrowth individual populations, spatial segregation reduce competition. Here, we highlight the role advances engineering, biofilm production living materials, biosensing. Additionally, discuss challenges future research consortia.

Language: Английский

Citations

81
Synthetic co-cultures: novel avenues for bio-based processes DOI Creative Commons
Martijn Diender, Ivette Parera Olm, Diana Z. Sousa

et al.

Current Opinion in Biotechnology, Journal Year: 2021, Volume and Issue: 67, P. 72 - 79

Published: Jan. 28, 2021

In nature, microorganisms live in multi-species communities allowing microbial interactions. These interactions are lost upon establishing a pure culture, increasing the metabolic burden and limiting potential of isolated microbe. past years, synthetic co-cultivation, using well-defined consortia two or more microbes, was increasingly explored for innovative applications biotechnology. As such, interspecies take place without complexity an open mixed minimizing undesired side reactions. Ultimately, co-cultivation allows to well-characterized microbes 'off-the-shelf' create ecosystems with improved process capabilities. This review highlights some recent developments on focusing waste-to-chemicals conversions. It also addresses fundamental knowledge deriving from these studies, which is important further develop our ability engineer functional co-cultures bioproduction.

Language: Английский

Citations

79
Customized materials-assisted microorganisms in tumor therapeutics DOI
Qi‐Wen Chen,

Jiyan Qiao,

Xinhua Liu

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(22), P. 12576 - 12615

Published: Jan. 1, 2021

This review provides a comprehensive introduction to microorganisms-based biohybrid systems, namely MAMO, for application in tumor therapeutics.

Language: Английский

Citations

71
Challenges and Future Perspectives of Promising Biotechnologies for Lignocellulosic Biorefinery DOI Creative Commons
Yansong Liu, Yunhan Tang, Haiyan Gao

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(17), P. 5411 - 5411

Published: Sept. 6, 2021

Lignocellulose is a kind of renewable bioresource containing abundant polysaccharides, which can be used for biochemicals and biofuels production. However, the complex structure hinders final efficiency lignocellulosic biorefinery. This review comprehensively summarizes hydrolases typical microorganisms degradation. Moreover, commonly bioprocesses biorefinery are also discussed, including separated hydrolysis fermentation, simultaneous saccharification fermentation consolidated bioprocessing. Among these methods, construction microbial co-culturing systems via bioprocessing regarded as potential strategy to efficiently produce biofuels, providing theoretical direction constructing efficient stable process system in future.

Language: Английский

Citations

68
Powering a microprocessor by photosynthesis DOI
Paolo Bombelli,

Anand Savanth,

Alberto Scarampi

et al.

Energy & Environmental Science, Journal Year: 2022, Volume and Issue: 15(6), P. 2529 - 2536

Published: Jan. 1, 2022

A photosynthesis-driven biophotovoltaic system with an Al-anode powered a microprocessor widely used in IoT applications stably for over six months.

Language: Английский

Citations

60
Current Advances in the Biodegradation and Bioconversion of Polyethylene Terephthalate DOI Creative Commons

Xinhua Qi,

Wenlong Yan,

Zhibei Cao

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 10(1), P. 39 - 39

Published: Dec. 26, 2021

Polyethylene terephthalate (PET) is a widely used plastic that polymerized by terephthalic acid (TPA) and ethylene glycol (EG). In recent years, PET biodegradation bioconversion have become important in solving environmental pollution. More more hydrolases been discovered modified, which mainly act on degrade the ester bond of PET. The monomers, TPA EG, can be further utilized microorganisms, entering tricarboxylic cycle (TCA cycle) or being converted into high value chemicals, finally realizing Based synthetic biology metabolic engineering strategies, this review summarizes current advances modified hydrolases, engineered microbial chassis degrading PET, pathways artificial consortia bioconversion. Artificial consortium provides novel ideas for other complex polymers. It helpful to realize one-step chemicals.

Language: Английский

Citations

58
Division of labor for substrate utilization in natural and synthetic microbial communities DOI Creative Commons
Razieh Rafieenia, Eliza Atkinson, Rodrigo Ledesma‐Amaro

et al.

Current Opinion in Biotechnology, Journal Year: 2022, Volume and Issue: 75, P. 102706 - 102706

Published: March 4, 2022

In natural ecosystems, microorganisms live in communities where each member interacts with the others and environment to efficiently utilise available resources. Division of Labor (DOL) is an evolutionary strategy that evolved by microbial accomplish complex tasks. Current bio-based technologies could also benefit from DOL construct robust cell factories expanded metabolic capabilities. Here, we review some remarkable examples how used consortia utilize a range substrates. Also, most recent studies towards engineering design synthetic for efficient substrate utilization bioproduction.

Language: Английский

Citations

48
Bioconversion of food and lignocellulosic wastes employing sugar platform: A review of enzymatic hydrolysis and kinetics DOI
Raffel Dharma Patria, Shazia Rehman, Arun K. Vuppaladadiyam

et al.

Bioresource Technology, Journal Year: 2022, Volume and Issue: 352, P. 127083 - 127083

Published: March 30, 2022

Language: Английский

Citations

47
Current Advances in Biodegradation of Polyolefins DOI Creative Commons
Ni Zhang, Ming‐Zhu Ding, Ying‐Jin Yuan

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(8), P. 1537 - 1537

Published: July 29, 2022

Polyolefins, including polyethylene (PE), polypropylene (PP) and polystyrene (PS), are widely used plastics in our daily life. The excessive use of improper handling methods cause considerable pollution the environment, as well waste energy. biodegradation polyolefins seems to be an environmentally friendly low-energy consumption method for degradation. Many strains that could degrade have been isolated from environment. Some enzymes also identified with function polyolefin With development synthetic biology metabolic engineering strategies, engineered plastics. This review summarizes current advances degradation, strains, related pathways. Furthermore, a novel strategy degradation by artificial microbial consortia is proposed, which would helpful efficient polyolefin.

Language: Английский

Citations

43
Construction of stable microbial consortia for effective biochemical synthesis DOI Open Access
Yujia Jiang, Ruofan Wu, Wenming Zhang

et al.

Trends in biotechnology, Journal Year: 2023, Volume and Issue: 41(11), P. 1430 - 1441

Published: June 16, 2023

Language: Английский

Citations

27