Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment DOI Creative Commons

Yong Fan,

Zhenguo Niu,

Li Yin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101778 - 101778

Published: April 17, 2025

Osteoarthritis (OA) is a progressive degenerative disorder which severely threatens the quality of life older individuals. OA progression closely related to heightened levels mitochondrial reactive oxygen species (mtROS). Although nanozymes have good ROS-scavenging effect, they cannot precisely scavenge mtROS because immune rejection cell membranes, lysosomal escape, and inability conventional directly target mitochondria. Dual-target were engineered in chondrocytes. We used chondrocyte membrane-camouflaged TPP-modified hollow Prussian blue subsequently encapsulated these hybrid glycyrrhizic acid hydrogel. The therapeutic efficacy underlying mechanisms assessed vitro vivo. novel enhanced selectivity, evasion capabilities, targeting. dual-targeted exerted pronounced impact on inflammatory chondrocytes, mitigated mtDNA leakage by scavenging mtROS, dampened cGAS-STING-NF-κB signaling, function. hydrogels also exhibited improved outcomes. confirmed beneficial effects nanozyme-hydrogel combination mice. can reduce avoiding suppressing signaling pathway, thereby decreasing responses alleviate progression.

Language: Английский

Self‐Reinforced MOF‐Based Nanogel Alleviates Osteoarthritis by Long‐Acting Drug Release DOI

Yun Sun,

Shenglong Ding, Xiyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Abstract Intra‐articular injection of drugs is an effective strategy for osteoarthritis (OA) treatment. However, the complex microenvironment and limited joint space result in rapid clearance drugs. Herein, a nanogel‐based proposed prolonged drug delivery remodeling. Nanogel constructed through functionalization hyaluronic acid (HA) by amide reaction on surface Kartogenin (KGN)‐loaded zeolitic imidazolate framework‐8 (denoted as KZIF@HA). Leveraging inherent hydrophilicity HA, KZIF@HA spontaneously forms nanogels, ensuring extended release OA microenvironment. exhibits sustained over one month, with low leakage risk from cavity compared to KZIF, enhanced cartilage penetration, reparative effects chondrocytes. Notably, KGN released serves promote extracellular matrix (ECM) secretion hyaline regeneration. Zn 2+ reverses progression promoting M2 macrophage polarization establish anti‐inflammatory Ultimately, facilitates regeneration alleviation within three months. Transcriptome sequencing validates that stimulates macrophages secretes IL‐10 inhibit JNK ERK pathways, chondrocytes recovery enhancing ECM This pioneering nanogel system offers new therapeutic opportunities release, presenting significant stride treatment strategies.

Language: Английский

Citations

23
Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing DOI Creative Commons
Wen Li, Huihui Zhang, Lianglong Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101595 - 101595

Published: Feb. 19, 2025

Language: Английский

Citations

4
Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface DOI Creative Commons
Yuwen Wang, Patrick Shu‐Hang Yung, Gang Lü

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: March 16, 2024

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their translation requires a deep understanding complex interplay between nanotechnology MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative versatile microphysiological platform to replicate dynamics tissue microenvironment studying nanotechnology-biology interactions. This review first covers recent advances applications OoCs ability mimic biophysical biochemical stimuli encountered by tissues. Next, integrating into OoCs, cellular responses behaviors may be investigated precisely controlling manipulating nanoscale environment. Analysis disease mechanisms, particularly bone, joint, muscle degeneration, drug screening development personalized medicine greatly facilitated using OoCs. Finally, future challenges directions outlined field, including advanced sensing technologies, integration immune-active components, enhancement biomimetic functionality. By highlighting emerging this aims advance intricate nanotechnology-MSK biology interface its significance in management, therapeutic interventional strategies.

Language: Английский

Citations

12
Ultrasmall Prussian Blue Nanozyme Attenuates Osteoarthritis by Scavenging Reactive Oxygen Species and Regulating Macrophage Phenotype DOI
Zhiguo Qin, Xiaofei Li, Peng Wang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(37), P. 11697 - 11705

Published: Sept. 3, 2024

Osteoarthritis (OA) is a degenerative joint disease characterized by obscure etiology and unsatisfactory therapeutic outcomes, making the development of new efficient therapies urgent. Superfluous reactive oxygen species (ROS) have historically been considered one crucial factors inducing pathological progression OA. Ultrasmall Prussian blue nanoparticles (USPBNPs), approximately sub-5 nm in size, are developed regulating configuration polyvinylpyrrolidone chains. USPBNPs display an excellent ROS eliminating capacity catalase-like activity, capable decomposing hydrogen peroxide (H

Language: Английский

Citations

7
Medical Applications and Prospects of Polylactic Acid Materials DOI Creative Commons
Zechuan Yang, Guoyong Yin, Shuyang Sun

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111512 - 111512

Published: Dec. 1, 2024

Language: Английский

Citations

7
Synovial Lubrication Factors‐Recruiting Biomimetic Polyphenolized Hyaluronic Acid for Promoting Cartilage Repair DOI
Hui Yuan,

Pengcheng Xiao,

Bruno Sarmento

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Osteoarthritis is a common degenerative disease characterized by continuous detachment of lubrication factors from damaged cartilage matrix. This study proposes paradigm that combines natural polyanionic polysaccharides (hyaluronic acid, HA) with dopamine (DA) to design synovial factors‐recruiting biomimetic polyphenolized system. The lubricants can use DA's polarity and hydrophilic groups as specific binding sites type II collagen's stably bind surface, further utilize molecular interaction recruit detached, joint endogenous or chondrocytes expressed factors, continuously forming supramolecular complex onto matrix induce lubrication. Simultaneously, the biolubricants also catechol eliminate anionic free radicals resist reactive oxygen species invasion in early stages failure. prepared exhibit low coefficient friction (µ < 0.08), which attributed fluid hydration provided HA DA side chains through dynamic effect interfacial adsorption. Cell animal experiments demonstrate polyphenolic have good biocompatibility promote regeneration. Therefore, developed lubricants‐recruiting potential for treating osteoarthritis, provide theoretical basis other biological tissues problems.

Language: Английский

Citations

6
Nanomaterials: Recent Advances in Knee Osteoarthritis Treatment DOI
Yufeng Peng, Ying Wang, Ru Bai

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Osteoarthritis (OA) of the knee is most prevalent degenerative joint condition that places a substantial financial and medical burden on society. However, due to drawbacks such as inefficiency, adverse effects, brief duration action, clinical efficacy current major therapies for OA largely restricted. Therefore, novel medication development highly required address these issues. Numerous studies in recent years have established nanomaterials can be potential effective way overcome challenges. In this review, anatomical distinctions between healthy joints, well advances field treatment are summarized. The limits present therapeutic strategies treating also highlighted, prospects future.

Language: Английский

Citations

6
PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration DOI Creative Commons
Sheng Liu,

Kanglu Li,

Yuxin He

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: March 30, 2024

Abstract Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting markers senescence‐associated secretory phenotype (SASP), remains limited due challenges in precise delivery. Given that natural killer group 2D (NKG2D) ligands are increased on surface senescent nucleus pulposus (NP) cells, NKG2D‐overexpressing NP cell membranes (NNPm) constructed, which expected achieve dual effect toward cells based homologous membrane fusion NKG2D‐mediated immunosurveillance mechanism. Then, mesoporous silica nanoparticles carrying peroxisome proliferator‐activated receptor‐ɣ coactivator 1α (PGC1α)inducer (SP) coated with NNPm (SP@NNPm) it found SP@NNPm selectively targets SP cores exhibit pH‐responsive drug release. Moreover, effectively induces PGC1α‐mediated mitochondrial biogenesis mitigates induced by oxidative stress SASP, thereby alleviating puncture‐induced This dual‐targeting nanotherapeutic system represents novel approach delivery for degeneration treatment.

Language: Английский

Citations

5
Harnessing Engineered Extracellular Vesicles from Mesenchymal Stem Cells as Therapeutic Scaffolds for Bone‐Related Diseases DOI
Tingting Yu, Jingwei Wang, Yusai Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: March 19, 2024

Abstract Mesenchymal stem cells (MSCs) play a crucial role in maintaining bone homeostasis and are extensively explored for cell therapy various bone‐related diseases. In addition to direct therapy, the secretion of extracellular vesicles (EVs) by MSCs has emerged as promising alternative approach. MSC‐derived EVs (MSC‐EVs) offer equivalent therapeutic efficacy while mitigating potential risks. These possess unique properties that enable them traverse biological barriers deliver bioactive cargos target cells. Furthermore, employing modification engineering strategies, effects tissue targeting specificity MSC‐EVs can be further enhanced meet specific needs. this review, mechanisms advantages MSC‐EV diseased tissues highlighted. Through simple isolation techniques, MSC‐EV‐based biomaterials have demonstrated great promise regeneration. Finally, future perspectives on presented, envisioning development next‐generation regenerative materials agents clinical translation field

Language: Английский

Citations

4
Bone Destruction-Chemotactic Osteoprogenitor Cells Deliver Liposome Nanomedicines for the Treatment of Osteosarcoma and Osteoporosis DOI
Yu Chen, Qi‐Wen Chen,

Fang-Sheng Fu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29864 - 29879

Published: Oct. 18, 2024

Therapeutic efficacy of skeletal diseases is usually limited by unfavorable drug delivery due to incapable bone targeting and low affinity conventional carriers, as well relatively reduced vascularization dense structure tissues. Due CXC chemokine receptor 4 (CXCR4)/CXC ligand 12 (CXCL12) signal axis-guided recruitment, osteoprogenitor cells (OPCs) can actively migrate disease nidus. Here, drugs-loaded nanoliposomes are prepared decorated onto OPCs biotin–streptavidin linkage for precise effective delivery. In mouse models tibia defect orthotopic osteosarcoma, superior property OPCs-based systems toward diseased niduses verified. By encapsulating antitumor antiosteoporosis drugs into nanoliposomes, effectively inhibit development restore destruction in osteosarcoma ovariectomized osteoporosis. This study reveals a cell-based system highly delivery, which will find great potential universal platform treatment various diseases.

Language: Английский

Citations

4