Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF‐1α Signaling Pathway DOI Creative Commons
Jiabin Zhou, Lei Yu, Shilin Zhang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Cerebral ischemic stroke (CIS) is a debilitating neurological condition lacking specific treatments. ischemia/reperfusion injury (CIRI) critical pathological process in CIS. Purpose This study aimed to explore the protective effects of panaxadiol (PD) against oxidative stress‐induced neuronal apoptosis CIS/CIRI and its underlying mechanisms. Method An MCAO mouse model was established investigate therapeutic PD vivo. Network pharmacology molecular docking techniques were used predict PD's anti‐CIS targets. The further validated vitro using oxygen–glucose deprivation/reoxygenation (OGD/R)‐treated HT22 cells. Finally, core targets verified through combined vivo experiments elucidate mechanisms treating Result exhibited significant neuroprotective activity, demonstrated by restoration behavioral performance, reduced infarct volume, decreased mice. analysis identified 24 overlapping target genes between CIS‐related hub genes, PTGS2, SERPINE1, ICAM‐1, STAT3, MMP3, HMOX1, NOS3, associated with HIF‐1α pathway, which may play crucial role effects. Molecular confirmed stable binding these genes. Both that significantly mitigates stress induced CIS/CIRI. Conclusion counteracts modulating JAK3/STAT3/HIF‐1α signaling making it promising agent for

Language: Английский

Systemic inflammation after stroke: implications for post‐stroke comorbidities DOI Creative Commons
Alba Simats, Arthur Liesz

EMBO Molecular Medicine, Journal Year: 2022, Volume and Issue: 14(9)

Published: Aug. 15, 2022

Language: Английский

Citations

127
Gut liver brain axis in diseases: the implications for therapeutic interventions DOI Creative Commons

Mengyao Yan,

Shuli Man,

Benyue Sun

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 6, 2023

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In past few decades, breakthrough progress has been made in gut liver brain axis, mainly through understanding its formation mechanism increasing treatment strategies. this review, we discuss various complex networks including barrier permeability, hormones, microbial metabolites, vagus nerve, neurotransmitters, immunity, toxic β-amyloid (Aβ) metabolism, epigenetic regulation gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet nanotechnology application regulate Besides, some special treatments targeting gut-liver include farnesoid X receptor (FXR) agonists, takeda G protein-coupled 5 (TGR5) glucagon-like peptide-1 (GLP-1) antagonists fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain embraces cognitive behavioral therapy (CBT), antidepressants tryptophan metabolism-related therapies. liver-brain contains Aβ future, better interactions will promote development novel preventative strategies discovery precise therapeutic targets multiple diseases.

Language: Английский

Citations

86
The immunomodulatory mechanisms for acupuncture practice DOI Creative Commons
Meng Wang, Weili Liu,

Jiayi Ge

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

The system physiology approaches that emerge in western countries recent years echo the holistic view of ancient Traditional Chinese Medicine (TCM) practices deal with root, rather than only symptoms diseases. Particularly, TCM practices, including acupuncture, emphasize mobilization self-healing mechanisms to bring back body homeostasis. Acupuncture has been practiced for over two thousand modulate via stimulation at specific regions (acupoints). With development various research on acupuncture therapy, its regulatory effect immune gradually recognized, especially immunological diseases, infectious and allergic In this study, we reviewed immunomodulatory mechanism systematically integrates existing respectively elucidate modulatory innate system, adaptive well-known neuroanatomical mechanisms, intact somatosensory-autonomic reflex pathway. advances made systems studies, now have a great opportunity gain insight into how modulates immunity, subsequently improves efficacy.

Language: Английский

Citations

68
Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study DOI Creative Commons
Qi Wang,

Huajie Dai,

Tianzhichao Hou

et al.

Journal of Stroke, Journal Year: 2023, Volume and Issue: 25(3), P. 350 - 360

Published: Sept. 26, 2023

We investigated the causal relationships between gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR).We leveraged summary statistics of GM (n=18,340 in MiBioGen consortium), blood metabolites (n=115,078 UK Biobank), stroke (cases n=60,176 controls n=1,310,725 Global Biobank Meta-Analysis Initiative) from largest genome-wide association studies to date. performed bidirectional MR analyses explore two mediation analyses, two-step multivariable MR, discover mediating metabolites.Ten taxa were causally associated with led changes 27 taxa. In Bifidobacteriales order, Bifidobacteriaceae family, Desulfovibrio genus, apolipoprotein A1 (ApoA1), phospholipids high-density lipoprotein (HDL_PL), ratio B ApoA1 (ApoB/ApoA1) (all P<0.044). The associations family validated weighted median method an independent cohort. three all positively HDL_PL, whereas genus was negatively ApoB/ApoA1 P<0.010). Additionally, remained significant after correcting for false discovery rate q-values <0.027). Multivariable showed that mediated by each accounting 6.5% (P=0.028) 4.6% (P=0.033); ApoA1, ApoB/ApoA1, proportions 7.6% (P=0.019), 4.2% (P=0.035), 9.1% (P=0.013), respectively.The current study provides evidence supporting several specific metabolites.

Language: Английский

Citations

47
The gut microbiota–brain axis in neurological disorders DOI Creative Commons

Mingming You,

Nan Chen,

Yuanyuan Yang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Language: Английский

Citations

15
Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk DOI Creative Commons

Ling Xie,

Ming He,

Caidi Ying

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: June 12, 2024

Stroke is a devastating disease with high morbidity, disability, and mortality, among which ischemic stroke more common. However, there still lack of effective methods to improve the prognosis reduce incidence its complications. At present, evidence that peripheral organs are involved in inflammatory response after stroke. Moreover, interaction between central inflammation includes activation resident immune cells, as well inflammation-related signaling pathways, all play an important role pathophysiology In this review, we discuss mechanisms stroke, interactions through circulatory pathways (such gut, heart, lung spleen) brain mediate regulate We also propose potential meningeal lymphatic vessels (MLVs)-cervical lymph nodes (CLNs) brain-peripheral crosstalk pathway addition, summarize anti-inflammatory drugs treatment

Language: Английский

Citations

10
Dietary index for gut microbiota is associated with stroke among US adults DOI
Jingjing Liu, Shaoqiang Huang

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The dietary index for gut microbiota was inversely associated with stroke prevalence, particularly in adults aged 30 years and above.

Language: Английский

Citations

1
Multi-Omics Analysis of the Gut-Brain Axis Elucidates Therapeutic Mechanisms of Guhong Injection in the Treatment of Ischemic Stroke DOI Open Access

Pingting Mao,

Jianhua Hu,

Xi Mai

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1560 - 1560

Published: Feb. 12, 2025

Guhong injection (GH) is a compound preparation widely utilized in the treatment of cerebrovascular diseases. Accumulating evidence indicates that gut microbiota implicated development ischemic stroke (IS). However, although therapeutic potential GH IS may be mediated through microbiota, intricate relationships among gut-brain axis, biomarkers, and target proteins remain to completely explained. A rat model middle cerebral artery occlusion (MCAO) was investigate impact on IS. Our 16S rRNA sequence analysis revealed markedly enhanced α-diversity intestinal microbiome rectified imbalance short-chain fatty acids (SCFAs). Metabolomic indicated reversed 45 biomarkers 6 disordered metabolic pathways MCAO rats. Among these, arachidonic acid, α-linolenic fructose, mannose were closely associated with comprising Lactobacillus modulated by GH. Furthermore, IS-related signaling pathways, including inflammation, autophagy, oxidative stress, apoptosis, significantly three microbial species influenced The efficacy context multiple involving SCFAs, proteins. This process partly relies axis.

Language: Английский

Citations

1
Benefits of equilibrium between microbiota- and host-derived ligands of the aryl hydrocarbon receptor after stroke in aged male mice DOI Creative Commons

Pedram Peesh,

Maria P. Blasco-Conesa, Ahmad El Hamamy

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 19, 2025

Language: Английский

Citations

1
Sex differences in the inflammatory response to stroke DOI
Muhammad Bilal Tariq, Juneyoung Lee, Louise D. McCullough

et al.

Seminars in Immunopathology, Journal Year: 2022, Volume and Issue: 45(3), P. 295 - 313

Published: Nov. 10, 2022

Language: Английский

Citations

34