Toxicology in Vitro, Journal Year: 2024, Volume and Issue: unknown, P. 105974 - 105974
Published: Nov. 1, 2024
Language: Английский
iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109350 - 109350
Published: Feb. 27, 2024
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality, with metastasis being primary determinant poor prognosis in patients. Investigating molecular mechanisms underlying CRC is currently a prominent and challenging area research. Exosomes, crucial intercellular communication mediators, facilitate transfer metabolic genetic information from cells origin to recipient cells. Their roles mediating exchange between immune cells, fibroblasts, other cell types are pivotal reshaping tumor microenvironment, regulating key biological processes such invasion, migration, formation pre-metastatic niche. This article comprehensively examines function mechanism exosomes derived different metastasis, while also presenting an outlook on current research advancements future application prospects. The aim offer distinctive perspective that contributes accurate diagnosis rational treatment strategies for CRC.
Language: Английский
Citations
9
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 8, 2025
Colorectal cancer (CRC) is one of thes most prevalent malignant tumors worldwide. Current therapeutic strategies for CRC have limitations, while nanomaterials show significant potential diagnosing and treating CRC. This study utilizes bibliometric analysis to evaluate the current status trends in this field. Research on from 2003 2024 was retrieved Web Science Core Collection (WOSCC). Tools such as CiteSpace, VOSviewer, RStudio, GraphPad Prism, Excel were used analyze hotspots, covering publication trends, countries, institutions, authors, journals, co-citation analysis, keywords. Visual maps created forecast future developments. The includes 3,683 publications by 17,261 authors 3,721 institutions across 100 countries/regions, published 840 journals. Global steadily increased, particularly since 2018. China leads volume citations, with six top ten research seven cited United States excels citation impact academic centrality. Both countries currently dominate field, underscoring urgent need enhanced international collaboration. Ramezani M Abnous K lead H-index, Siegel RL highly cited. International Journal Nanomedicine has highest volume, Controlled Release In addition "colorectal cancer" "nanoparticles," common keyword "drug delivery." Emerging areas "metal-organic frameworks (MOFs)" "green synthesis" are gaining attention leading hotspots. offers an in-depth application CRC, promoting interdisciplinary collaboration advancing scientific progress
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 23, 2024
Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, lipids can serve as messengers for intercellular communication. They play critical roles in the exchange information between tumor cells microenvironment (TME). The TME consists mesenchymal components extracellular matrix (ECM), fibroblasts being most abundant cell type mesenchyme. Cancer-associated (CAFs) derived from normal stem that activated TME. CAFs secrete exosomes to modulate proliferation, invasion, migration, drug resistance, other biological processes tumors. Additionally, manipulate function behavior through direct cell-cell interactions. This review provides summary crosstalk GI exosomes, along potential underlying mechanisms.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7470 - 7470
Published: July 8, 2024
Colorectal cancer (CRC) is a significant public health challenge, with 5-fluorouracil (5-FU) resistance being major obstacle to effective treatment. Despite advancements, 5-FU remains formidable due complex mechanisms such as alterations in drug transport, evasion of apoptosis, dysregulation cell cycle dynamics, tumor microenvironment (TME) interactions, and extracellular vesicle (EV)-mediated pathways. Traditional chemotherapy often results high toxicity, highlighting the need for alternative approaches better efficacy safety. Phytochemicals (PCs) EVs offer promising CRC therapeutic strategies. PCs, derived from natural sources, exhibit lower toxicity can target multiple pathways involved progression resistance. facilitate targeted delivery, modulate immune response, interact TME sensitize cells However, potential PCs engineered overcoming reshaping immunosuppressive underexplored. Addressing this gap crucial identifying innovative therapies enhanced reduced toxicities. This review explores multifaceted evaluates synergistic effects combining improve treatment while minimizing adverse effects. Additionally, it investigates by serving delivery vehicles modulating TME. By synthesizing current knowledge addressing research gaps, enhances academic understanding CRC, interdisciplinary involving revolutionizing therapy. Further clinical validation are essential translating these findings into improved patient outcomes.
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 567 - 567
Published: April 21, 2024
Extracellular vesicles (EVs), acting as inherent nanocarriers adept at transporting a range of different biological molecules such proteins, lipids, and genetic material, exhibit diverse functions within the gastroenteric tract. In states normal health, they participate in upkeep systemic organ homeostasis. Conversely, pathological conditions, significantly contribute to pathogenesis gastrointestinal diseases (GIDs). Isolating EVs from patients' biofluids facilitates discovery new biomarkers that have potential offer rapid, cost-effective, non-invasive method for diagnosing prognosing specific GIDs. Furthermore, demonstrate considerable therapeutic naturally targeted physiological carriers intercellular delivery cargo or nanoscale tools engineered specifically regulate physio-pathological conditions disease progression. Their attributes including safety, high permeability, stability, biocompatibility, low immunogenicity, homing/tropism capabilities their promising clinical applications. This review will delve into various examples serving context GIDs, highlighting both functional structural conditions. The versatile advantageous properties position them candidates innovative strategies advancing personalized medicine approaches tailored tract, addressing
Language: Английский
Citations
5
Photochemical & Photobiological Sciences, Journal Year: 2024, Volume and Issue: 23(7), P. 1361 - 1372
Published: June 12, 2024
Language: Английский
Citations
4
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 113 - 126
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Language: Английский
Citations
0
Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(4)
Published: March 31, 2025
ABSTRACT Colorectal cancer (CRC) is a prevalent malignancy of the digestive system. Here, we explored role M2 macrophage‐derived extracellular vesicles (EVs) carrying long non‐coding RNA‐nuclear paraspeckle assembly transcript 1 (lncRNA‐NEAT1) in promoting CRC progression via regulation miR‐204‐5p/regulator ribosome synthesis (RRS1) axis and cell cycle dynamics. Firstly, differentiated WTHP‐1 cells into M0 macrophages transfected with sh‐NEAT1 lentivirus plasmids. EVs were isolated from administered to SW480 along miR‐204‐5p inhibitors or si‐RRS1 for 24 h. M2‐EVs‐derived lncRNA‐NEAT1 enhanced proliferation, migration, invasion, viability while reducing apoptosis. This was accompanied by increased expression RRS1, WEE1 G2 checkpoint kinase (WEE1), cyclin‐dependent (CDK1), CyclinB1, reduced levels, lower proportion G2/M phase. Knockdown reversed these effects. Mechanistically, functioned as competing endogenous RNA (ceRNA), sponging upregulate RRS1 expression. In summary, promote development modulating miR‐204‐5p/RRS1 axis, influencing These findings provide insights tumor‐promoting mechanisms CRC.
Language: Английский
Citations
0
Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100434 - 100434
Published: May 1, 2025
Language: Английский
Citations
0