Cited by Liquiritin apioside alleviates colonic inflammation and accompanying depression-like symptoms in colitis by gut metabolites and the balance of Th17/Treg

Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored DOI

Mengjie Zhu,

Yijie Song, Yu Xu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 11004 - 11004

Published: July 2, 2023

Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn's (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD offers promising strategies for remedies. A brief overview the variations occurring in during presented, role gut microbiota barrier maintenance, immune metabolic regulation, absorption supply nutrients reviewed. More importantly, we review drug research on past ten years, including clinical natural drugs, well adjuvant therapies, such Fecal Microbiota Transplantation probiotic supplements. We also summarize interventions mechanisms these drugs microbiota.

Language: Английский

Citations

Bacteroides acidifaciens and its derived extracellular vesicles improve DSS-induced colitis DOI

Cihua Zheng,

Yuchun Zhong,

Jian Xie

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 30, 2023

"Probiotic therapy" to regulate gut microbiota and intervene in intestinal diseases such as inflammatory bowel disease (IBD) has become a research hotspot. Bacteroides acidifaciens, new generation of probiotics, shown beneficial effects on various diseases.In this study, we utilized mouse colitis model induced by dextran sodium sulfate (DSS) investigate how B. acidifaciens positively affects IBD. We evaluated the ofB. fecal transplantation, bacterial extracellular vesicles (EVs) DSS-induced mice. monitored phenotype colitis, detected serum factors using ELISA, mucosal barrier function Western blotting tissue staining, 16S rRNA sequencing, analyzed differences EVs protein composition derived from proteomics explore positive impact colitis.We confirmed that protective effect including alleviating phenotype, reducing response, improving function, accompanied an increase relative abundance Ruminococcus callidus but decrease fragilis. Further transplantation or filtrate eosinophil-regulated metabolites colitis. Finally, validated contain rich functional proteins can contribute relief colitis.Therefore, its alleviate damage colon tissue, promoting repair, restoring diversity, balance The results study provide theoretical basis for preclinical application probiotics.

Language: Английский

Citations

5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner DOI

Qing Meng,

Jianshuang Guo,

Ke Lv

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2153 - 2176

Published: Feb. 29, 2024

Aberrant changes in the gut microbiota are implicated many diseases, including inflammatory bowel disease (IBD). Gut microbes produce diverse metabolites that can shape immune system and impact intestinal barrier integrity, indicating microbe-mediated modulation may be a promising strategy for preventing treating IBD. Although fecal transplantation probiotic supplementation well-established IBD therapies, novel chemical agents safe exert strong effects on urgently needed. Herein, we report total synthesis of heudelotinone discovery 5

Language: Английский

Citations

Dissecting mechanisms of fecal microbiota transplantation efficacy in disease DOI

Catherine M. Andary, Kait F. Al,

John A. Chmiel

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(3), P. 209 - 222

Published: Jan. 8, 2024

Language: Английский

Citations

Revisiting the Role of Valeric Acid in Manipulating Ulcerative Colitis DOI

Moting Liu, Yao Zhang, Jia Liu

et al.

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: 30(4), P. 617 - 628

Published: Jan. 11, 2024

Abstract Background Ulcerative colitis (UC) is characterized by a complicated interaction between mucosal inflammation, epithelial dysfunction, abnormal activation of innate immune responses, and gut microbiota dysbiosis. Though valeric acid (VA), one type short-chain fatty acids (SCFAs), has been identified in other inflammatory disorders cancer development, the pathological role VA underlying mechanism UC remain under further investigation. Methods Studies human clinical specimens experimental models were conducted to confirm manifestations level SCFAs from fecal samples murine colonic homogenates. Valeric acid–intervened macrophage adoptive transfer applied identify mechanisms. Results In line with dysfunction UC, alteration microbes patients dextran sodium sulfate –induced models. Notably, was consistently negatively related disease severity population monocytes, interluekin-6. Moreover, treatment showed direct suppressive effects on lipopolysaccharides (LPS)-activated peripheral blood mononuclear cells macrophages dependent manner upregulation GPR41 GPR43. Therapeutically, replenishment or VA-modulated resistance sulfate–driven though modulating production cytokine interleukin-6. Conclusions summary, research uncovered suggested that might be potential effective agent for patients.

Language: Английский

Citations

Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model DOI

Jutuan Hu,

Yuxia Mei, Heng Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130959 - 130959

Published: March 17, 2024

Language: Английский

Citations

Polysaccharide fromPleurotus tuber-regiummycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota DOI

Cuiyuan Mo,

Ruofan Liu, Zhenhua Yang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(7), P. 3731 - 3743

Published: Jan. 1, 2024

Pleurotus tuber-regium (PTR) has been proved to have obvious pharmacological properties. In this study, a polysaccharide was extracted from the mycelium of PTR and administered DSS-induced colitis mice clarify protective effect mechanism (PTRP) on colitis. The results showed that PTRP significantly improved clinical symptoms intestinal tissue damage caused by inhibited secretion pro-inflammatory cytokines myeloperoxidase activity, while levels oxidative stress factors in decreased antioxidant capacity increased. 16S rRNA sequencing mouse cecum content changed composition gut microbiota, diversity abundance beneficial bacteria addition, also enhanced production short-chain fatty acids regulating microbiota. conclusion, our study shows potential relieve IBD protect function inflammatory cytokines,

Language: Английский

Citations

Synbiotics containing sea buckthorn polysaccharides ameliorate DSS-induced colitis in mice via regulating Th17/Treg homeostasis through intestinal microbiota and their production of BA metabolites and SCFAs DOI

Mingyou Yuan,

Lili Chang,

Pan Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133794 - 133794

Published: July 9, 2024

Language: Английский

Citations

Stress Tolerance and Metabolism Profiling of Selected Functional Probiotic Strains DOI

Shing Ching Khoo, Kah Wei Chin,

Tai Zhi Ting

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105919 - 105919

Published: Jan. 1, 2025

Language: Английский

Citations

Effects of senotherapeutics on gut microbiome dysbiosis and intestinal inflammation in Crohn's Disease: A Pilot Study DOI

Nannapat Sangfuang, Laura E. McCoubrey, Atheer Awad

et al.

Translational research, Journal Year: 2025, Volume and Issue: 278, P. 36 - 47

Published: Feb. 20, 2025

Language: Английский

Citations