Effect of Bacillus clausii Capsules in Reducing Adverse Effects Associated with Helicobacter pylori Eradication Therapy: A Randomized, Double-Blind, Controlled Trial DOI Creative Commons

Manuel Plomer,

Marcos III Perez,

Dorothea Maren Greifenberg

et al.

Infectious Diseases and Therapy, Journal Year: 2020, Volume and Issue: 9(4), P. 867 - 878

Published: Sept. 8, 2020

Antibiotic treatment can alter the gut microbiome and cause short-term gastrointestinal adverse effects (AEs). This study assessed efficacy of lyophilized capsules containing 2 × 109 spores Bacillus clausii (Enterogermina®; Sanofi Synthelabo) in reducing AEs associated with Helicobacter pylori eradication therapy Italy. In this randomized, double-blind, single-center, phase IIIB study, 130 adult outpatients H. infection were assigned to receive one Enterogermina® capsule or placebo three times daily for weeks (1:1). During week 1, all patients received clarithromycin 500 mg, amoxicillin 1 g, rabeprazole 20 mg twice daily. The primary outcome was presence diarrhea 1. A total randomized. incidence 29% B. group 48% [relative risk (RR) 0.61; 95% confidence interval (CI) 0.39–0.97; p = 0.03]. remained lower than (RR 0.38; CI 0.14–1.02; 0.0422). number days without significantly higher (6.25 vs. 5.86; 0.0304). both groups, increased (p < 0.0001) from 2. occurred two group, but none serious. Compared placebo, reduced of, with, receiving therapy. well tolerated.

Language: Английский

Sex differences and considerations for female specific nutritional strategies: a narrative review DOI Creative Commons
Kealey J. Wohlgemuth, Luke R. Arieta, Gabrielle J. Brewer

et al.

Journal of the International Society of Sports Nutrition, Journal Year: 2021, Volume and Issue: 18(1)

Published: Jan. 2, 2021

Although there is a plethora of information available regarding the impact nutrition on exercise performance, many recommendations are based male needs due to dominance participation in and science literature. Female sport prevalent, making it vital for guidelines address sex-specific nutritional needs. hormonal levels, such as estrogen progesterone, fluctuate throughout mensural cycle lifecycle requiring more attention effective considerations. Sex-specific active female athlete have been lacking date warrant further consideration. This review provides practical overview key physiological considerations female. Available literature dietary supplement women has synthesized, offering evidenced-based that can be incorporated into daily lives improve body composition, overall health.

Language: Английский

Citations

66

The Athlete Gut Microbiome and its Relevance to Health and Performance: A Review DOI Creative Commons
Marcus O’Brien, Órla O’Sullivan, Marcus J. Claesson

et al.

Sports Medicine, Journal Year: 2022, Volume and Issue: 52(S1), P. 119 - 128

Published: Nov. 18, 2022

Abstract The human gut microbiome is a complex ecosystem of microorganisms that play an important role in health, influencing functions such as vitamin uptake, digestion and immunomodulation. While research the has expanded considerably over past decade, some areas relationship between exercise remain relatively under investigated. Despite this, multiple studies have shown potential bidirectional microbiome, with demonstrating possibility this relationship. This, turn, could provide useful route to influence athletic performance via manipulation, valuable prospect for many elite athletes their teams. evidence supporting benefits pursuing associated future perspectives are discussed review.

Language: Английский

Citations

38

Microbiota Effect on Trimethylamine N-Oxide Production: From Cancer to Fitness—A Practical Preventing Recommendation and Therapies DOI Open Access
Edoardo Tacconi, Giuseppe Palma, Davide De Biase

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 563 - 563

Published: Jan. 21, 2023

Trimethylamine N-oxide (TMAO) is a microbial metabolite derived from nutrients, such as choline, L-carnitine, ergothioneine and betaine. Recently, it has come under the spotlight for its close interactions with gut microbiota implications gastrointestinal cancers, cardiovascular disease, systemic inflammation. The culprits in origin of these pathologies may be food sources, particular, high fat meat, offal, egg yolk, whole dairy products, fatty fish, but intercalated between sources production pro-inflammatory TMAO, composition plays an important role modulating this process. aim review to explain how interacts conversion specific compounds into TMA oxidation TMAO. We will first cover correlation TMAO various dysbiosis, then focus on particular emphasis pro-atherogenic factors, inflammation cancers. Finally, we discuss primary prevention therapies that are or become possible. Possible treatments include modulation species diets, physical activity supplements, administration drugs, metformin aspirin.

Language: Английский

Citations

28

An Updated View of the Effect of Probiotic Supplement on Sports Performance: A Detailed Review DOI Creative Commons
Miray Nur Aykut, Esma Nur Erdoğan, Menşure Nur Çelik

et al.

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(2), P. 251 - 263

Published: March 12, 2024

Abstract Purpose of Review Modulation the host microbiota through probiotics has been shown to have beneficial effects on health in growing body research. Exercise increases amount and diversity microorganisms microbiome. Although low- moderate-intensity exercise reduce physiological stress improve immune function, high-intensity prolonged can suppress function microbial due intestinal hypoperfusion. The effect probiotic supplementation sports performance is still being studied; however, questions remain regarding mechanisms action, strain used, dose. In this review, aim was investigate supplements modulation gut alleviation GI symptoms, promotion system, bioavailability nutrients, aerobic metabolism. Recent Findings Probiotic may by reducing adverse exercise. Summary reported positive performance, information about microbiome nutrition athletes not considered most current studies. This limited evaluation performance.

Language: Английский

Citations

10

Epithelial barrier theory in the context of nutrition and environmental exposure in athletes DOI Creative Commons
Walter Kistler, Michael Villiger,

B Villiger

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(11), P. 2912 - 2923

Published: July 16, 2024

Exposure to toxic substances, introduced into our daily lives during industrialization and modernization, can disrupt the epithelial barriers in skin, respiratory, gastrointestinal systems, leading microbial dysbiosis inflammation. Athletes physically active individuals are at increased risk of exposure agents that damage microbiome, their extreme physical exercise exerts stress on many organs, resulting tissue Epithelial barrier-damaging substances include surfactants enzymes cleaning products, laundry dishwasher detergents, chlorine swimming pools, microplastics, air pollutants such as ozone, particulate matter, diesel exhaust. Athletes' high-calorie diet often relies processed foods may contain food emulsifiers other additives cause barrier dysfunction dysbiosis. The type material used sport equipment clothing extensive increase inflammatory effects. Excessive travel-related stress, sleep disturbances different microbe represent additional factors. Here, we review detrimental impact microbiome; bring a new perspective factors affecting health performance athletes individuals.

Language: Английский

Citations

9

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation DOI Open Access
Wen-Ching Huang, Chun Pan,

Chen-Chan Wei

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(8), P. 2315 - 2315

Published: Aug. 1, 2020

A triathlon is an extremely high-intensity exercise and a challenge for physiological adaptation. triathlete’s microbiome might be modulated by diet, age, medical treatments, lifestyle, exercise, thereby maintaining aerobiosis optimum health performance. Probiotics, prebiotics, synbiotics have been reported to health-promoting activities (e.g., immunoregulation cancer prevention). However, few studies addressed how probiotics affect the microbiota of athletes this translates into functional activities. In our previous study, we found that Lactobacillus plantarum PS128 could ameliorate inflammation oxidative stress, with improved Thus, here investigate triathletes are altered L. supplementation, not only performance but also possible The were assigned two groups: 128 supplement group (LG, 3 × 1010 colony-forming units (CFU)/day) placebo (PG). Both groups continued their regular training next 4 weeks. endurance performance, body composition, biochemistries, blood cells, microbiota, associated metabolites further investigated. significantly increased athletes’ endurance, about 130% as compared PG group, there was no significant difference in maximal oxygen consumption (VO2max) composition between groups. supplementation (LG) athlete’s both decreases (Anaerotruncus, Caproiciproducens, Coprobacillus, Desulfovibrio, Dielma, Family_XIII, Holdemania, Oxalobacter) increases (Akkermansia, Bifidobacterium, Butyricimonas, Lactobacillus), LG showed lower diversity when PG. Also, short-chain fatty acids (SCFAs; acetate, propionate, butyrate) higher than PG, which result modulation microbiota. conclusion, improvement on running through related metabolites, uptake.

Language: Английский

Citations

66

Impact of Protein Intake in Older Adults with Sarcopenia and Obesity: A Gut Microbiota Perspective DOI Open Access
Konstantinos Prokopidis, Mavil May Cervo, Anoohya Gandham

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(8), P. 2285 - 2285

Published: July 30, 2020

The continuous population increase of older adults with metabolic diseases may contribute to increased prevalence sarcopenia and obesity requires advocacy optimal nutrition treatments combat their deleterious outcomes. Sarcopenic obesity, characterized by age-induced skeletal-muscle atrophy adiposity, accelerate functional decline the risk disability mortality. In this review, we explore influence dietary protein on gut microbiome its impact obesity. Given associations between red meat proteins altered microbiota, a combination plant animal-based are deemed favorable for microbiota eubiosis muscle-protein synthesis. Additionally, high-protein diets elevated essential amino-acid concentrations, alongside fiber intake, promote eubiosis, given effects derived from short-chain fatty-acid branched-chain production. conclusion, greater abundance specific bacteria associated satiation, synthesis, overall health be driven consumption. This could counteract development and, therefore, represent novel approach recommendations based profile. However, more human trials utilizing advanced metabolomic techniques investigate relationship macronutrient especially protein, warranted.

Language: Английский

Citations

65

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates DOI Open Access
Diego A. Bonilla,

Alexandra Pérez-Idárraga,

Adrián Odriozola-Martínez

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 18(1), P. 103 - 103

Published: Dec. 25, 2020

Post-exercise recovery is a broad term that refers to the restoration of training capacity. After or competition, there fatigue accumulation and reduction in sports performance. In hours days following training, body recovers performance expected return normal improve. ScienceDirect, PubMed/MEDLINE, Google Scholar databases were reviewed identify studies position declarations examining relationship between nutrition recovery. As an evidence-based framework, 4R’s approach optimizing post-exercise was identified: (i) Rehydration—a fundamental process will depend on athlete, environment event; (ii) Refuel—the consumption carbohydrates not only important replenish glycogen reserves but also contribute energy requirements for immune system tissue reparation. Several bioengineered discussed further research needed; (iii) Repair—post-exercise ingestion high-quality protein creatine monohydrate benefit growth repair; (iv) Rest—pre-sleep has restorative effect facilitates musculoskeletal, endocrine, immune, nervous systems. Nutritional consultancy based wise stewardship hydration, feeding, supplementation strategies achieve timely

Language: Английский

Citations

52

The Effect of Lactobacillus plantarum 299v on Iron Status and Physical Performance in Female Iron-Deficient Athletes: A Randomized Controlled Trial DOI Open Access
Ulrika Axling,

Gunilla Önning,

Maile A. Combs

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(5), P. 1279 - 1279

Published: April 30, 2020

Iron is an essential micronutrient for oxygen transport and mitochondrial metabolism critical physical performance. Compromised iron stores are more commonly found among athletes, females especially at risk. deficiency generally treated using oral supplements. However, only a small proportion of ingested absorbed, necessitating higher intakes, which may result in adverse side effects, reduced compliance, inefficient repletion stores. The probiotic strain Lactobacillus plantarum 299v (Lp299v) significantly increases intestinal absorption meal studies. present study was conducted to explore the effects 20 mg with or without Lp299v on status, mood state, Fifty-three healthy non-anemic female athletes low (ferritin < 30 μg/L) were randomized, 39 completed study. Intake four weeks increased ferritin levels than alone (13.6 vs. 8.2 µg/L), but difference between groups not significant (p = 0.056). mean reticulocyte hemoglobin content after intake compared control (1.5 0.82 pg) 12 weeks, group 0.083). Profile Mood States (POMS) questionnaire showed vigor (3.5 0.1, p 0.015). No conclusive performance observed. In conclusion, Lp299v, together iron, could substantial rapid improvement status improved alone. A larger clinical trial needed further these findings as well impact

Language: Английский

Citations

50

Advances in sports food: Sports nutrition, food manufacture, opportunities and challenges DOI
Pengbo Cui, Mengyu Li,

Mingxiao Yu

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 157, P. 111258 - 111258

Published: April 16, 2022

Language: Английский

Citations

37