Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement

Obesity Facts, Journal Year: 2022, Volume and Issue: 15(3), P. 321 - 335

Published: Jan. 1, 2022

<b><i>Introduction:</i></b> Loss of skeletal muscle mass and function (sarcopenia) is common in individuals with obesity due to metabolic changes associated a sedentary lifestyle, adipose tissue derangements, comorbidities (acute chronic diseases) during the ageing process. Co-existence excess adiposity low mass/function referred as sarcopenic (SO), condition increasingly recognized for its clinical functional features that negatively influence important patient-centred outcomes. Effective prevention treatment strategies SO are urgently needed, but efforts hampered by lack universally established definition diagnostic criteria. Resulting inconsistencies literature also affect ability define prevalence well relevance negative health <b><i>Aims Methods:</i></b> The European Society Clinical Nutrition Metabolism (ESPEN) Association Study Obesity (EASO) launched an initiative reach expert consensus on criteria SO. jointly appointed international panel proposes defined co-existence mass/function. diagnosis should be considered at-risk who screen positive co-occurring elevated body index or waist circumference, markers (risk factors, symptoms, validated questionnaires). Diagnostic procedures initially include assessment function, followed composition where presence related compartments confirm Individuals further stratified into stage I absence complications II if cases linked altered dysfunction. <b><i>Conclusions:</i></b> ESPEN EASO, panel, advocate proposed implemented routine practice. encourages prospective studies addition secondary analysis existing data sets, study predictive value, efficacy impact this definition.

Language: Английский

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Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(4), P. 990 - 1000

Published: Feb. 23, 2022

Loss of skeletal muscle mass and function (sarcopenia) is common in individuals with obesity due to metabolic changes associated a sedentary lifestyle, adipose tissue derangements, comorbidities (acute chronic diseases), during the ageing process. Co-existence excess adiposity low mass/function referred as sarcopenic (SO), condition increasingly recognized for its clinical functional features that negatively influence important patient-centred outcomes. Effective prevention treatment strategies SO are urgently needed, but efforts hampered by lack an universally established Definition diagnostic criteria. Resulting inconsistencies literature also affect ability define prevalence well relevance negative health outcomes.The European Society Clinical Nutrition Metabolism (ESPEN) Association Study Obesity (EASO) launched initiative reach expert consensus on criteria SO. The jointly appointed international panel proposes defined co-existence mass/function. diagnosis should be considered at-risk who screen positive co-occurring elevated body index or waist circumference, markers (risk factors, symptoms, validated questionnaires). Diagnostic procedures initially include assessment function, followed composition where presence related compartments confirm Individuals further stratified into Stage I absence complications, II if cases complications linked altered dysfunction.ESPEN EASO, panel, advocate proposed implemented routine practice. encourages prospective studies addition secondary analysis existing datasets, study predictive value, efficacy, impact this definition.

Language: Английский

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The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 2045 - 2045

Published: June 15, 2021

Living longer is associated with an increased risk of chronic diseases, including impairments the musculoskeletal and immune system as well metabolic disorders certain cancers, each which can negatively affect relationship between host microbiota up to occurrence dysbiosis. On other hand, lifestyle factors, regular physical exercise a healthy diet, skeletal muscle aging positively at all ages. Accordingly, health benefits could partly depend on effect such interventions that influence biodiversity functionality intestinal microbiota. In present review, we first discuss physiological effects gut microbiota, system, muscle. Secondly, describe human epidemiological evidence about associations activity fitness composition in older adults. The third part highlights relevance restorative mechanisms protection through specific during aging. Fourth, important research findings protein nutrients performance Finally, provide nutritional recommendations prevent malnutrition support active focus Key nutrition-related concerns include need for adequate energy intake preventing low mass higher demand (e.g., dietary fiber, polyphenols polyunsaturated fatty acids) modify composition, diversity, capacity may thus practical means enhancing systemic function.

Language: Английский

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Sarcopenic Obesity: An Emerging Public Health Problem

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(2), P. 379 - 379

Published: Jan. 1, 2022

Population aging and the obesity epidemic are important global public health problems that pose an unprecedented threat to physical mental of elderly systems worldwide. Sarcopenic (SO) is a new category high-risk geriatric syndrome in elderly. SO associated with many adverse consequences such as frailty, falls, disability, increased morbidity mortality. The core mechanism vicious circle between myocytes adipocytes. In order implement effective prevention treatment strategies reduce clinical outcomes, it essential further our understanding Herein, we reviewed definition, diagnosis, epidemiology, pathogenesis, older adults.

Language: Английский

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The Gut-Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(23), P. 8946 - 8946

Published: Nov. 25, 2020

The gut microbiota could influence the pathophysiology of age-related sarcopenia through multiple mechanisms implying modulation chronic inflammation and anabolic resistance. aim this study was to compare fecal composition functionality, assessed by shotgun metagenomics sequencing, between two groups elderly outpatients, differing only for presence primary sarcopenia. Five sarcopenic subjects twelve non-sarcopenic controls, classified according lower limb function bioimpedance-derived skeletal muscle index, provided a stool sample, which analyzed with approaches, determine overall composition, representation bacteria at species level, prediction bacterial genes involved in functional metabolic pathways. Sarcopenic displayed different compositions significant depletion known their capacity producing short-chain fatty acids (SCFAs), Faecalibacterium prausnitzii Roseburia inulinivorans, Alistipes shahii. Additionally, metagenome had belonging 108 pathways, namely, SCFA synthesis, carotenoid isoflavone biotransformation, amino acid interconversion. These results support hypothesis an association sarcopenia, indicating novel possible mediators, whose clinical relevance should be investigated future studies.

Language: Английский

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Bioactive compounds in legumes: Implications for sustainable nutrition and health in the elderly population

Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 117, P. 139 - 147

Published: March 12, 2021

Language: Английский

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Defining and diagnosing sarcopenia: Is the glass now half full?

Metabolism, Journal Year: 2023, Volume and Issue: 143, P. 155558 - 155558

Published: April 7, 2023

Language: Английский

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Animal and vegetable protein intake and malnutrition in older adults: a multicohort study

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(1), P. 100002 - 100002

Published: Jan. 1, 2024

Malnutrition is a global concern in older adults, as it negatively affects morbidity and mortality. While higher animal protein intake may help prevent treat malnutrition, might also increase the risk of chronic diseases death. Conversely, vegetable have lower anabolic effect not be effective to improve nutritional status. We studied whether are associated with changes status adults. used pooled data from two Spanish cohorts: Seniors-ENRICA 1 2. 2,965 community-dwelling adults aged 62–92 years. Protein was estimated at baseline via an electronic, validated diet history. Nutritional assessed after 2.6 years GLIM (Global Leadership Initiative on Malnutrition) phenotypic criteria: weight loss, low body mass index, reduced muscle mass. The odds improvements were logistic regression models, extensively adjusted for potential confounders. Higher [odds ratios (95% confidence intervals) per 0.25 g/kg/day 1.15 (1.00, 1.32) 1.77 (1.35, 2.32), respectively]. Cereal drove most latter association [2.07 (1.44, 2.98)]. Replacing total protein, meat, or fish (but dairy egg protein) [1.54 (1.13, 2.09), 1.70 (1.20, 2.41), (1.18, 2.64), and, especially, malnutrition.

Language: Английский

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The interaction between Mediterranean diet and intestinal microbiome: relevance for preventive strategies against frailty in older individuals

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: March 6, 2024

Age-related changes in intestinal microbiome composition and function are increasingly recognized as pivotal the pathophysiology of aging associated with phenotype. Diet is a major determinant gut-microbiota throughout entire lifespan, several benefits healthy diet could be mediated by microbiome. Mediterranean (MD) traditional dietary pattern regarded paradigm, large number studies have demonstrated its promoting aging. MD has also positive modulatory effect on microbiome, favoring bacterial taxa involved synthesis bioactive compounds, such short-chain fatty acids (SCFAs), that counteract inflammation, anabolic resistance, tissue degeneration. Intervention conducted older populations suggested individual response subjects to MD, terms reduction frailty scores amelioration cognitive function, significantly functionality. In this context, should considered when designing MD-based interventions tailored needs geriatric patients.

Language: Английский

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A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity

Nutrients, Journal Year: 2020, Volume and Issue: 12(10), P. 3221 - 3221

Published: Oct. 21, 2020

Background: High protein calorie restriction diets have shown clinical efficacy for obesity, but the mechanisms are not fully known. The intestinal microbiome is a mediator of obesity and preclinical data support an effect high diet (HPD) on gut there few studies in humans. Methods: To address this, we conducted dietary intervention trial 80 overweight obese subjects who were randomized to calorie-restricted (30% intake) or normal (NPD) (15%) 8 weeks. Baseline intake patterns assessed by Diet History Questionnaire III. Longitudinal fecal sampling was performed at baseline, week 1, 2, 4, 6, 8, total 365 samples. Intestinal composition 16S rRNA gene sequencing. Results: At microbial associated with fiber intake. Subjects HPD showed significant increase diversity as measured Shannon index compared those NPD. also differences after treatment Both induced taxonomic shifts including enrichment Akkermansia spp. Bifidobacterium depletion Prevotella Conclusion: These findings provide evidence that weight loss alter suggest differential effects HPDs NPDs which may influence response HPD.

Language: Английский

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