Benign non-immune cells in tumor microenvironment DOI Creative Commons
Shaowen Liu, Chunhui Liu, Yuan He

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

The tumor microenvironment (TME) is a highly complex and continuous evolving ecosystem, consisting of diverse array cellular non-cellular components. Among these, benign non-immune cells, including cancer-associated fibroblasts (CAFs), adipocytes, endothelial cells (ECs), pericytes (PCs), Schwann (SCs) others, are crucial factors for development. Benign within the TME interact with both immune cells. These interactions contribute to progression through direct contact indirect communication. Numerous studies have highlighted role that exert on potential tumor-promoting mechanisms via multiple signaling pathways factors. However, these may play different roles across cancer types. Therefore, it important understand based heterogeneity. A deep understanding allows us develop novel therapies by targeting In this review, we will introduce several types according heterogeneity their in TME.

Language: Английский

SIRT1/SREBPs-mediated regulation of lipid metabolism DOI Creative Commons
Shan Shen, Mingyang Shen,

Lirun Kuang

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107037 - 107037

Published: Dec. 7, 2023

Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is warranted explore the advantageous impacts of Sirtuin 1 (SIRT1), a constituent sirtuin group, lipid metabolism, in addition its well-researched involvement extending lifespan. The regulation gene expression has been extensively linked SIRT1. Sterol regulatory element-binding protein (SREBP) substrate SIRT1 attracted significant interest due role multiple cellular processes including cell cycle regulation, DNA damage repair, and metabolic functions. Hence, objective this analysis was investigate elucidate correlation between SREBPs, well assess contribution SIRT1/SREBPs mitigating metabolism dysfunction. research whether SREBPs could be utilized viable targets for therapeutic intervention managing complications associated with diabetes.

Language: Английский

Citations

39
Cancer-Associated Adipocytes and Breast Cancer: Intertwining in the Tumor Microenvironment and Challenges for Cancer Therapy DOI Open Access
Chenghui Wu, Shuwen Dong, Renhong Huang

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 726 - 726

Published: Jan. 24, 2023

Adipocytes are the main components in breast tissue, and cancer-associated adipocytes (CAAs) one of most important tumor microenvironment cancer (BC). Bidirectional regulation was found between CAAs BC cells. facilitates dedifferentiation adjacent to form with morphological biological changes. increase secretion multiple cytokines adipokines promote tumorigenesis, progression, metastasis by remodeling extracellular matrix, changing aromatase expression, metabolic reprogramming, shaping immune microenvironment. also associated therapeutic response provide potential targets therapy. The present review provides a comprehensive description crosstalk discusses strategies target overcome treatment resistance.

Language: Английский

Citations

29
N6‐methyladenosine‐modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis‐regulated Hippo pathway DOI Creative Commons

Daojia Miao,

Qi Wang, Jian Shi

et al.

Cancer Communications, Journal Year: 2023, Volume and Issue: 43(4), P. 480 - 502

Published: March 1, 2023

The mechanism of metabolism reprogramming is an unsolved problem in clear cell renal carcinoma (ccRCC). Recently, it was discovered that the Hippo pathway altered tumor and promoted progression. Thus, this study aimed at identifying key regulators ccRCC pinpointing potential therapeutic targets for patients.Hippo-related gene sets metabolic were used to screen ccRCC. Public databases samples from patients applied investigate association dihydrolipoamide branched chain transacylase E2 (DBT) with signaling. role DBT confirmed by gain or loss function assays vitro vivo. Mechanistic results yielded luciferase reporter assay, immunoprecipitation, mass spectroscopy, mutational studies.DBT as a Hippo-related marker significant prognostic predictive value, its downregulation caused methyltransferase-like-3 (METTL3)-mediated N6-methyladenosine (m6 A) modification Functional studies specified suppressor inhibiting progression correcting lipid disorder findings revealed annexin A2 (ANXA2) interacted lipoyl-binding domain activate signaling which led decreased nuclear localization yes1-associated transcriptional regulator (YAP) repression lipogenic genes.This demonstrated tumor-suppressive DBT/ANXA2/YAP axis-regulated suggested target pharmaceutical intervention

Language: Английский

Citations

24
Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy DOI Creative Commons
Ziqing He, Xiyu Liu,

Simin Qin

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 636 - 636

Published: May 15, 2024

Astragalus polysaccharide (APS) derived from A. membranaceus plays a crucial role in traditional Chinese medicine. These polysaccharides have shown antitumor effects and are considered safe. Thus, they become increasingly important cancer immunotherapy. APS can limit the spread of by influencing immune cells, promoting cell death, triggering autophagy, impacting tumor microenvironment. When used combination with other therapies, enhance treatment outcomes reduce toxicity side effects. combined checkpoint inhibitors, relay cellular immunotherapy, vaccines broadened application immunotherapy enhanced effectiveness. By summarizing research on over past two decades, this review elaborates anticancer mechanism its use clinical trials. Considering multiple roles APS, emphasizes importance using as an adjunct to compares APS. This discussion provides insights into specific action reveals molecular targets for developing effective strategies, highlights wide therapy future.

Language: Английский

Citations

10
AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review DOI
Sandra Maria Barbalho, Nahúm Méndez‐Sánchez, Lucas Fornari Laurindo

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 218, P. 115871 - 115871

Published: Oct. 20, 2023

Language: Английский

Citations

18
AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis DOI Creative Commons
Wuping Tan, Yijun Wang,

Siyi Cheng

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Obesity and imbalance in lipid homeostasis contribute greatly to heart failure with preserved ejection fraction (HFpEF), the dominant form of failure. Few effective therapies exist control metabolic alterations homeostasis.

Language: Английский

Citations

7
Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer DOI

Cora E Miracle,

Chelsea L. McCallister,

Richard D Egleton

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150437 - 150437

Published: July 23, 2024

Language: Английский

Citations

7
A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation DOI
Ling Chen, Guiying Xu,

Xiaoxu Song

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 583, P. 216635 - 216635

Published: Jan. 17, 2024

Language: Английский

Citations

6
Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism DOI

Xiaodan Lyu,

Qian Zhang,

Hamza M. Fares

et al.

Cancer Letters, Journal Year: 2022, Volume and Issue: 534, P. 215616 - 215616

Published: March 3, 2022

Language: Английский

Citations

24
Targeting Adiponectin in Breast Cancer DOI Creative Commons
Rawan Nehme,

Mona Diab‐Assaf,

Caroline Decombat

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(11), P. 2958 - 2958

Published: Nov. 17, 2022

Obesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, relationship between obesity has been well established extensively investigated. There is strong evidence overweight increase risk of postmenopausal cancer, adipokines central players in this relationship. Produced secreted predominantly by white adipose tissue, adiponectin a bioactive molecule exhibits numerous protective effects considered guardian angel adipokine. obesity–cancer relationship, more shows may prevent protect individuals from developing cancer. Recently, several updates have published on implication regulating tumor development, progression, metastases. review, we provide an updated overview metabolic signaling linking all its stages. On other hand, critically summarize available promising candidates reactivate these pathways mainly targeting receptors. These molecules synthetic small or plant-based proteins. Interestingly, advances genomics made it possible create peptide sequences specifically replace adiponectin, activate receptor, mimic function. Thus, obvious anti-cancer activity should better exploited, must regarded serious biomarker targeted order confront threatening disease.

Language: Английский

Citations

23