The Gut Microbiome and Female Health

Biology, Journal Year: 2022, Volume and Issue: 11(11), P. 1683 - 1683

Published: Nov. 21, 2022

The possession of two X chromosomes may come with the risk various illnesses, females are more likely to be affected by osteoarthritis, heart disease, and anxiety. Given reported correlations between gut microbiome dysbiosis female is worthy exploration. Herein, we discuss composition microbiota its in pathologies affecting population. Using PubMed, performed a literature search, using key terms, namely: “gut microbiome”, “estrogen”, “menopause”, “polycystic ovarian syndrome”, “pregnancy”, “menstruation”. In polycystic syndrome (PCOS), abundance Bacteroides vulgatus, Firmicutes, Streptococcus, ratio Escherichia/Shigella was found increased while that Tenericutes ML615J-28, 124-7, Akkermansia, Ruminococcaceae, Bacteroidetes S24-7 reduced. breast cancer, Clostridiales enhanced, cervical Prevotella, Porphyromonas, Dialister were enhanced but Bacteroides, Alistipes, members Lachnospiracea, decreased. Prevotella increased. Interestingly, administration Lactobacillus acidophilus, Bifidobacterium bifidum, reuteri, fermentum ameliorated PCOS symptoms mix lactis W51, bifidum W23, brevis W63, W52, salivarius W24, acidophilus W37, Lactococcus W19, casei W56, W58 alleviated vascular malfunction arterial stiffness obese postmenopausal women, finally, further research needed, maybe protective against bone mass loss. As several studies report therapeutic potential probiotics since certain pathological states has been relatively characterized, speculate bacterial species as warranted, novel independent or adjunct therapies for pathologies.

Language: Английский

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The maternal gut microbiome during pregnancy and its role in maternal and infant health

Current Opinion in Microbiology, Journal Year: 2023, Volume and Issue: 74, P. 102309 - 102309

Published: April 15, 2023

There is growing knowledge that the maternal gut microbiome undergoes substantial changes during pregnancy. However, despite recognition influences and infant health, we still have a limited understanding of clinical environmental factors can impact pregnancy consequences these changes. Here, review current body about shaping its role in development complications health.

Language: Английский

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The sow vaginal and gut microbiota associated with longevity and reproductive performance

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 7, 2025

Abstract Background Sow longevity and reproductivity are essential in the modern swine industry. Although many studies have focused on genetic genomic factors for selection, little is known about associations between microbiome sows with reproduction. Results In this study, we collected sequenced rectal vaginal swabs from 48 sows, nine of which completed up to four parities (U4P group), exhibiting reproductive longevity. We first identified predictors sow rectum (e.g., Akkermansia ) vagina Lactobacillus U4P group using RandomForest early breeding stage parity. Interestingly, these bacteria showed decreased predicted KEGG gene abundance involved biosynthesis amino acids. Then, tracked longitudinal changes over sows. LEfSe analysis revealed parity-associated that existed both Streptococcus Parity 1, 2, Veillonella 4). also patterns bacterial change (d 0) d 110, such as , was all parties. Furthermore, potential better performance. Finally, discovered Prevotellaceae NK3B31 total number piglets born throughout vagina. Conclusions This study highlights how reproduction within parities. The identification parity-associated, pregnancy-related, performance-correlated provides foundation targeted modulation improve animal production.

Language: Английский

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Sources of gut microbiota variation in a large longitudinal Finnish infant cohort

EBioMedicine, Journal Year: 2023, Volume and Issue: 94, P. 104695 - 104695

Published: July 1, 2023

Although the infant gut microbiota has been extensively studied, comprehensive assessment on determinants including technical variables not performed in large cohorts.

Language: Английский

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Gut microbiota-derived metabolites associate with circulating immune cell subsets in unexplained recurrent spontaneous abortion

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24571 - e24571

Published: Jan. 1, 2024

Currently, the precise causes of over 40 % recurrent spontaneous abortion (RSA) cases cannot be identified, leading to term "unexplained RSA" (URSA). Through an exploration gut microbiota, metabolites, and immune cell subsets in URSA, this study establishes a link between microbiota-derived metabolites cells. The results indicate reduced diversity microbiota URSA. Targeted metabolomic analyses reveal decreased levels deoxycholic acid (DCA), glycolithocholic (GLCA), acetate, propionate, butyrate Furthermore, elevated frequencies Th1, Th17, plasma B cells, along with Tregs Bregs, are observed peripheral blood demonstrate correlations bile acids short-chain fatty various circulation. Collectively, uncovers association circulating

Language: Английский

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Parity and gestational age are associated with vaginal microbiota composition in term and late term pregnancies

EBioMedicine, Journal Year: 2022, Volume and Issue: 81, P. 104107 - 104107

Published: June 24, 2022

Vaginal microbiota and its potential contribution to preterm birth is under intense research. However, only few studies have investigated the vaginal in later stages of pregnancy or at onset labour.We used 16S rRNA gene amplicon sequencing analyse cross-sectional swab samples from 324 Finnish women between 37-42 weeks gestation, sampled before elective caesarean section, spontaneous labour, pregnancies lasting ≥41 gestation. Microbiota data were combined with comprehensive clinical identify factors associated variation.Vaginal composition strongly advancing gestational age parity, i.e. presence previous deliveries. Absence deliveries was a strong predictor Lactobacillus crispatus dominated microbiota, relative abundance L. higher late term pregnancies, especially among nulliparous women.This study identified reproductive history as underlying high gynaecological health-associated pregnant women. Our results suggest that affects reflects regulation duration gestation labour onset, potentially vast utilities. Further are needed address causality mechanisms on how but not pregnancy, microbiota. Parity should be accounted for future outcomes.This research supported by EU H2020 programme Sweet Crosstalk ITN (814102), Academy Finland, State Research Funding, University Helsinki.

Language: Английский

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Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR ON AGE Birth Cohort

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(1)

Published: Jan. 1, 2023

Background: The gut microbiome plays an essential role in human health. Despite the link between air pollution exposure and various diseases, its association with during susceptible life periods remains scarce. Objectives: In this study, we examined black carbon particles quantified prenatal postnatal biological matrices bacterial richness diversity measures, families. Methods: A total of 85 stool samples were collected from 4- to 6-y-old children enrolled ENVIRonmental influence ON early AGEing birth cohort. We performed 16S rRNA gene sequencing calculate indices (Chao1 richness, Shannon diversity, Simpson diversity) relative abundance Black via white light generation under femtosecond pulsed laser illumination placental tissue cord blood, employed as biomarkers, urine, used a post-natal biomarker. robust multivariable-adjusted linear models examine associations loads measures index) (Shannon indices), adjusting for parity, season delivery, batch, age, sex, weight height child, maternal education. Additionally, differential analysis families correction sampling fraction bias. Results are expressed percentage difference doubling 95% confidence interval (CI). Results: Two negatively associated [Shannon: −4.38% (95% CI: −8.31%, −0.28%); Simpson: −0.90% −1.76%, −0.04%)], blood −3.38% −5.66%, −0.84%); −0.91 −1.66%, −0.16%)], urinary −3.39% −5.77%, −0.94%); −0.89% −1.37%, −0.40%)]. explained variance on above varied 6.1% 16.6%. No statistically significant found load Chao1 index. After multiple testing correction, was Defluviitaleaceae Marinifilaceae, Christensenellaceae Coriobacteriaceae; not after correction. Conclusion: composition childhood intestinal microbiome. These findings address influential pregnancy https://doi.org/10.1289/EHP11257

Language: Английский

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Host–gut microbiota interactions during pregnancy

Evolution Medicine and Public Health, Journal Year: 2024, Volume and Issue: 12(1), P. 7 - 23

Published: Jan. 1, 2024

Abstract Mammalian pregnancy is characterized by a well-known suite of physiological changes that support fetal growth and development, thereby positively affecting both maternal offspring fitness. However, mothers also experience trade-offs between current future reproductive success, responses to these can result in mother–offspring fitness conflicts. Knowledge the mechanisms through which operate, as well contexts they critical for understanding evolution reproduction. Historically, hormonal during have been thought play pivotal role conflicts since directly indirectly influence metabolism, immunity, other aspects development. recent research suggests gut microbiota may an important role. Here, we create foundation exploring this constructing mechanistic model linking hormones, immunity metabolism microbiota. We posit marked hormones alter microbiome composition function via impacts on immune system. The then feeds back metabolism. dynamics are likely be involved mediating different health pregnancy. predict interactions describe vary across populations response environments. Moving forward, empirical studies combine microbial functional data with outcomes infants will allow us test evolutionary implications gestational microbiota, enriching our ecology physiology.

Language: Английский

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The effects of microbiota on reproductive health: A review

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(6), P. 1486 - 1507

Published: Sept. 6, 2022

Reproductive issues are becoming an increasing global problem. There is interest in the relationship between microbiota and reproductive health. Stable communities exist gut, tract, uterus, testes, semen. Various effects (e.g., epigenetic modifications, nervous system, metabolism) of dysbiosis can impair gamete quality; interfere with zygote formation, embryo implantation, development; increase disease susceptibility, thus adversely impacting capacity pregnancy. The maintenance a healthy protect host from pathogens, potential, reduce rates adverse pregnancy outcomes. In conclusion, this review discusses male female systems multiple animal species. It explores mechanisms on reproduction, factors that influence composition, applications disorder treatment detection. findings support novel approaches for managing diseases through improvement monitoring. addition, it will stimulate further systematic explorations microbiota-mediated reproduction.

Language: Английский

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Impact of Early Weaning on Development of the Swine Gut Microbiome

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1753 - 1753

Published: July 5, 2023

Considering that pigs are naturally weaned between 12 and 18 weeks of age, the common practice in modern swine industry weaning as early two four age increases challenges during this transition period. Indeed, young with an immature gut suddenly separated from sow, switched milk to a diet consisting only solid ingredients, subjected new social hierarchy mixing multiple litters. From perspective host development, under these conditions causes regression histological structure well digestive barrier functions. While is main center immunity mature animals, underdeveloped has yet contribute function until seven age. The microbiota or microbiome, essential contributor health nutrition their animal host, undergoes dramatic alterations transition, descriptive review aims present microbial ecology-based on events. communities dependent cross-feeding relationships, change substrate availability triggers cascade succession events stable composition reached. During process, unstable prone dysbiosis, which can devolve into diseased state. One potential strategy accelerate maturation microbiome would be identify species critical microbiomes, develop strategies facilitate establishment post-weaning communities.

Language: Английский

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