Regulatory Mechanisms of Vitellogenesis in Insects

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 28, 2021

Vitellogenesis is pre-requisite to insect egg production and embryonic development after oviposition. During vitellogenesis, the yolk protein precursor vitellogenin (Vg) mainly synthesized in fat body, transported by hemolymph through intercellular spaces (known as patency) follicular epithelium reach membrane of maturing oocytes, sequestered into oocytes via receptor-mediated endocytosis. Insect vitellogenesis governed two critical hormones, sesquiterpenoid juvenile hormone (JH) ecdysteriod 20-hydroxyecdysone (20E). JH acts principal gonadotropic stimulate basal hemimetabolous most holometabolous insects. 20E for some hymenopterans, lepidopterans dipterans. Furthermore, microRNA (miRNA) nutritional (amino acid/Target Rapamycin insulin) pathways interplay with signaling cascades control vitellogenesis. Revealing regulatory mechanisms underlying understanding reproduction helpful developing new strategies pest control. Here, we outline recent research progress molecular action along role miRNA sensor regulating We highlight advancements coordination hormone, pathways.

Language: Английский

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RNA Interference in Insects: From a Natural Mechanism of Gene Expression Regulation to a Biotechnological Crop Protection Promise

Biology, Journal Year: 2024, Volume and Issue: 13(3), P. 137 - 137

Published: Feb. 21, 2024

Insect pests rank among the major limiting factors in agricultural production worldwide. In addition to direct effect on crops, some phytophagous insects are efficient vectors for plant disease transmission. Large amounts of conventional insecticides required secure food worldwide, with a high impact economy and environment, particularly when beneficial also affected by chemicals that frequently lack desired specificity. RNA interference (RNAi) is natural mechanism gene expression regulation protection against exogenous endogenous genetic elements present most eukaryotes, including insects. Molecules double-stranded (dsRNA) or highly structured substrates cellular enzymes produce several types small RNAs (sRNAs), which play crucial role targeting sequences transcriptional post-transcriptional silencing. The relatively simple rules underlie RNAi regulation, mainly based Watson–Crick complementarity, have facilitated biotechnological applications these mechanisms. This includes promise using engineered dsRNA molecules, either endogenously produced crop plants exogenously synthesized applied onto as new generation specific, sustainable, environmentally friendly insecticides. Fueled this expectation, article reviews current knowledge about pathways insects, other questions such delivery recombinant RNA, critical establish reliable technology insect control plants.

Language: Английский

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Post-transcriptional regulation of insect metamorphosis and oogenesis

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 77(10), P. 1893 - 1909

Published: Nov. 13, 2019

Language: Английский

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Regulatory roles of microRNAs in insect pests: prospective targets for insect pest control

Current Opinion in Biotechnology, Journal Year: 2021, Volume and Issue: 70, P. 158 - 166

Published: June 2, 2021

Language: Английский

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Endocrine factors modulating vitellogenesis and oogenesis in insects: An update

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 587, P. 112211 - 112211

Published: March 15, 2024

Language: Английский

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The Role of MicroRNAs in Mammalian Fertility: From Gametogenesis to Embryo Implantation

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(2), P. 585 - 585

Published: Jan. 16, 2020

The genetic codes inscribed during two key developmental processes, namely gametogenesis and embryogenesis, are believed to determine subsequent development survival of adult life. Once the embryo is formed, its further mainly depends on intrinsic characteristics, maternal environment (the endometrial receptivity), embryo–maternal interactions established each phase development. These processes under strict regulation that could be manifested temporally spatially depending physiological status cell. MicroRNAs (miRNAs), one small non-coding classes RNAs, approximately 19–22 nucleotides in length, candidates for post-transcriptional regulators. tiny RNAs expressed ovarian tissue, granulosa cells, testis, oocytes, follicular fluid, embryos implicated diverse biological such as cell-to-cell communication. Moreover, accumulated evidences have also highlighted miRNAs can released into extracellular through different mechanisms facilitating intercellular Therefore, understanding mediated regulatory embryogenesis provides insights about molecular underlying oocyte/sperm formation, early development, implantation. Thus, this review highlights role mammalian summarizes recent findings miRNA-mediated occurring

Language: Английский

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Diversity of Insect Sesquiterpenoid Regulation

Frontiers in Genetics, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 10, 2020

Insects are arguably the most successful group of animals in world terms both species numbers and diverse habitats. The sesquiterpenoids juvenile hormone, methyl farnesoate farnesoic acid well known to regulate metamorphosis, reproduction, sexual dimorphism, eusociality, defense insects. Nevertheless, different insects have evolved with sesquiterpenoid biosynthetic pathway as products. On other hand, noncoding RNAs such microRNAs been implicated regulation many important biological processes, recently explored production. In this review, we summarise latest findings on diversity reported groups insects, recent advancements understanding production by microRNAs.

Language: Английский

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The Molecular Regulation in the Pathophysiology in Ovarian Aging

Aging and Disease, Journal Year: 2021, Volume and Issue: 12(3), P. 934 - 934

Published: Jan. 1, 2021

The female reproductive system is of great significance to women's health. Aging the occurs approximately 10 years prior natural age-associated functional decline other organ systems. With an increase in life expectancy worldwide, aging has gradually become a key health issue among women. Therefore, adequate understanding causes and molecular mechanisms ovarian essential towards inhibition age-related diseases promotion longevity In general, women begin experience function around age 35 years, which mainly manifested as decrease number follicles quality oocytes. Studies have revealed occurrence mitochondrial dysfunction, reduced DNA repair, epigenetic changes, metabolic alterations cells within ovaries increases. present work, we reviewed possible factors aging-induced insufficiency based on its clinical diagnosis performed in-depth investigation relevant potential targets provide novel approaches for effective improvement older

Language: Английский

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Kr-h1, a Cornerstone Gene in Insect Life History

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: April 27, 2022

Insect life cycle is coordinated by hormones and their downstream effectors. Krüppel homolog1 (Kr-h1) one of the crucial effectors which mediates actions two critical insects, juvenile hormone (JH) 20-hydroxyecdysone (20E). It a transcription factor with DNA-binding motif eight C 2 H zinc fingers found to be conserved among insect orders. The expression Kr-h1 fluctuant during development high abundance in instars lower levels final instar pupal stage, reappearance adults, governed coordination JH, 20E, miRNAs. dynamic pattern closely linked its function entire insects. Over past several years, accumulating studies have advanced our understanding role development. acts as universal antimetamorphic both hemimetabolous holometabolous species directly inhibiting 20E signaling genes Broad-Complex ( Br-C ) Ecdysone induced protein 93F E93 ), steroidogenic enzyme involved ecdysone biosynthesis. Meanwhile, it promotes vitellogenesis ovarian majority studied In addition, regulates behavioral plasticity caste identity, neuronal morphogenesis, maturation sexual behavior, well embryogenesis metabolic homeostasis. Hence, cornerstone regulator life.

Language: Английский

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Identification of differentially expressed miRNAs associated with diamide detoxification pathways in Spodoptera frugiperda

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 21, 2024

The fall armyworm (FAW) Spodoptera frugiperda is a severe economic pest of multiple crops globally. Control this often achieved using insecticides; however, over time, S. has developed resistance to new mode action compounds, including diamides. Previous studies have indicated diamide complex developmental process involving detoxification genes. Still, the mechanism underlying possible involvement microRNAs in post-transcriptional regulation not yet been elucidated. In study, global screen (miRNAs) revealed 109 known and 63 novel miRNAs. Nine miRNAs (four five novel) were differentially expressed between insecticide-resistant -susceptible strains. Gene Ontology analysis predicted putative target transcripts encoding significant genes belonging pathways. Additionally, are involved response exposure, indicating they probably associated with pathway. Thus, study provides comprehensive evidence for link repressed miRNA expression induced that possibly mediate through regulation. These findings highlight important clues further research unravel roles mechanisms conferring resistance.

Language: Английский

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