New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

Diabetologia, Journal Year: 2019, Volume and Issue: 62(9), P. 1539 - 1549

Published: July 25, 2019

Language: Английский

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‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

The Journal of Physiology, Journal Year: 2016, Volume and Issue: 594(12), P. 3187 - 3207

Published: March 1, 2016

The increasing ageing of our societies is accompanied by a pandemic obesity and related cardiometabolic disorders. Progressive dysfunction the white adipose tissue increasingly recognized as an important hallmark process, which in turn contributes to metabolic alterations, multi-organ damage systemic pro-inflammatory state ('inflammageing'). On other hand, obesity, paradigm dysfunction, shares numerous biological similarities with normal process such chronic inflammation multi-system alterations. Accordingly, understanding interplay between accelerated critical gain insight into general well pathophysiology conditions. Here we postulate concept 'adipaging' illustrate common links fact that, great extent, obese adults are prematurely aged individuals.

Language: Английский

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The diabetogenic action of statins — mechanisms and clinical implications

Nature Reviews Endocrinology, Journal Year: 2015, Volume and Issue: 12(2), P. 99 - 110

Published: Dec. 15, 2015

Language: Английский

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Oxidative stress in chronic kidney disease

Renal Replacement Therapy, Journal Year: 2018, Volume and Issue: 4(1)

Published: Dec. 1, 2018

For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovascular disease. One main novel risk factors oxidative stress, which occurs when there overproduction reactive oxygen species (ROS) and/or a reduction in antioxidant defense capacity. Oxidative stress involved progression renal injury, pathogenesis atherosclerosis, and exacerbation burden CKD patients. In addition, uremic- dialysis-associated these further contribute to via proinflammatory state, including exposure dialysate endotoxins or use bioincompatible hemodialysis dialyzer membranes. Consequences include amyloidosis, anemia. Strategies combat therapies such as vitamins C E N-acetylcysteine (NAC). While strategies are promising, few interventional studies have examined their effects until now. light disparate experimental clinical data, large, randomized, long-term required establish efficacy safety

Language: Английский

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Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Cardiovascular Diabetology, Journal Year: 2018, Volume and Issue: 17(1)

Published: June 30, 2018

Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin a cholesterol-lowering statin. However, both drugs act on glucose lipid metabolism which could lead to adverse effects when used in as compared monotherapy. In this review, proposed molecular mechanisms action statin patients dyslipidemia are critically assessed, hypothesis underlying interactions between these is developed.

Language: Английский

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The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study

Journal of Renal Nutrition, Journal Year: 2016, Volume and Issue: 26(4), P. 237 - 244

Published: Feb. 22, 2016

Language: Английский

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Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Revista Brasileira de Farmacognosia, Journal Year: 2022, Volume and Issue: 32(2), P. 174 - 187

Published: March 10, 2022

Language: Английский

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Statin initiation and risk of incident kidney disease in patients with diabetes

Canadian Medical Association Journal, Journal Year: 2023, Volume and Issue: 195(21), P. E729 - E738

Published: May 28, 2023

The role of statin therapy in the development kidney disease patients with type 2 diabetes mellitus (DM) remains uncertain. We aimed to determine relationships between initiation and outcomes DM.

Language: Английский

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Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 284 - 284

Published: March 15, 2024

Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage the heart, kidney, eyes, and nerves. Elevated brain function cognitive abilities. They also lead various neurological neuropsychiatric disorders, including neurodegeneration decline. High neuronal can cause drastic due neurotoxicity. Astrocytes, type glial cell, play vital role in maintaining through neuron–astrocyte coupling. Hyperglycemia progressive decline networks impairment, contributing dysfunction fostering neurodegenerative environment. In this review, we summarize connections, functions, impairments cells diabetic brain. We effects hyperglycemia on functions

Language: Английский

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Atorvastatin ameliorates diabetic nephropathy through inhibiting oxidative stress and ferroptosis signaling.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 976, P. 176699 - 176699

Published: June 1, 2024

Language: Английский

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