International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(15), P. 5478 - 5478
Published: July 31, 2020
The
disruption
of
circadian
rhythms
by
environmental
conditions
can
induce
alterations
in
body
homeostasis,
from
behavior
to
metabolism.
light:dark
cycle
is
the
most
reliable
agent,
which
entrains
rhythms,
although
its
credibility
has
decreased
because
extensive
use
artificial
light
at
night.
Light
pollution
compromise
performance
and
health,
but
underlying
mechanisms
are
not
fully
understood.
present
review
assesses
consequences
induced
constant
(LL)
comparison
with
dim
night
(dLAN)
on
control
metabolism
rodents,
since
such
an
approach
identify
key
chronodisruption.
Data
suggest
that
effects
LL
more
pronounced
compared
dLAN
directly
related
level
duration
exposure.
Dim
LAN
reduces
nocturnal
melatonin
levels,
similarly
LL,
corticosterone
behavioral
traits
uniform
improved
quantification
disrupted
needed.
Metabolism
under
strong
lead
various
pathologies.
Moreover,
only
output,
some
metabolites
peripheral
signal
molecules
feedback
clockwork
either
stabilize
or
amplify
desynchronization.
Diabetologia,
Journal Year:
2020,
Volume and Issue:
63(3), P. 462 - 472
Published: Jan. 8, 2020
The
circadian
system
generates
endogenous
rhythms
of
approximately
24
h,
the
synchronisation
which
are
vital
for
healthy
bodily
function.
timing
many
physiological
processes,
including
glucose
metabolism,
coordinated
by
system,
and
disruptions
that
desynchronise
or
misalign
these
can
result
in
adverse
health
outcomes.
In
this
review,
we
cover
role
its
disruption
metabolism
individuals
with
type
2
diabetes
mellitus.
We
begin
defining
then
provide
an
overview
regulation
metabolism.
next
discuss
impact
on
control
diabetes.
Given
concurrent
high
prevalence
disruption,
understanding
mechanisms
underlying
may
aid
improving
glycaemic
control.
European Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
51(1), P. 531 - 550
Published: Nov. 7, 2018
The
circadian
system
regulates
physiology
and
behavior.
Acute
challenges
to
the
system,
such
as
those
experienced
when
traveling
across
time
zones,
will
eventually
result
in
re-synchronization
local
environmental
cues,
but
this
is
oftentimes
accompanied
by
adverse
short-term
consequences.
When
are
chronically,
adaptation
may
not
be
achieved,
for
example
case
of
rotating
night
shift
workers.
transient
chronic
disturbance
most
frequently
referred
"circadian
disruption",
many
other
terms
have
been
proposed
used
refer
similar
situations.
It
now
beyond
doubt
that
contributes
health
disease,
emphasizing
need
clear
terminology
describing
their
goal
review
provide
an
overview
describe
disruption
discuss
quantifications
experimental
observational
settings
with
a
focus
on
human
research,
highlight
limitations
currently
available
tools.
For
research
advance
translational
science,
clear,
operationalizable,
scalable
key,
they
enable
improved
assessment
reproducibility
results,
ideally
ranging
from
mechanistic
settings,
including
animal
large-scale
randomized
clinical
trials.
Frontiers in Psychiatry,
Journal Year:
2018,
Volume and Issue:
9
Published: Dec. 5, 2018
Good
sleep
and
mood
are
important
for
health
keeping
active.
Numerous
studies
have
suggested
that
the
incidence
of
insomnia
depressive
disorder
linked
to
biological
rhythms,
immune
function
nutrient
metabolism,
but
exact
mechanism
is
not
yet
clear.
There
considerable
evidence
showing
gut
microbiome
only
affects
digestive,
metabolic,
functions
host
also
regulates
mental
states
through
microbiome-gut-brain
axis.
Preliminary
indicates
microorganisms
circadian
genes
can
interact
with
each
other.
The
characteristics
gastrointestinal
metabolism
related
host's
rhythm.
Moreover,
emotion
physiological
stress
affect
composition
microorganisms.
inflammation
may
be
loss,
misalignment,
affective
disorders
metabolic
disease.
In
this
review
article,
we
discuss
various
how
its
activities
rhythms
emotions
host.
Exploring
effects
on
depression
will
help
further
our
understanding
pathogenesis
disorders.
It
therefore
regulate
maintain
a
normal
micro-ecological
environment
in
patients
when
treating
BMJ,
Journal Year:
2018,
Volume and Issue:
unknown, P. k4641 - k4641
Published: Nov. 21, 2018
Abstract
Objectives
To
prospectively
evaluate
the
joint
association
of
duration
rotating
night
shift
work
and
lifestyle
factors
with
risk
type
2
diabetes
risk,
to
quantitatively
decompose
this
only,
their
interaction.
Design
Prospective
cohort
study.
Setting
Nurses’
Health
Study
(1988-2012)
II
(1991-2013).
Participants
143
410
women
without
diabetes,
cardiovascular
disease,
or
cancer
at
baseline.
Exposures
Rotating
was
defined
as
least
three
shifts
per
month
in
addition
day
evening
that
month.
Unhealthy
lifestyles
included
current
smoking,
physical
activity
levels
below
30
minutes
moderate
vigorous
intensity,
diet
bottom
fifths
Alternate
Healthy
Eating
Index
score,
body
mass
index
25
above.
Main
outcome
measures
Incident
cases
were
identified
through
self
report
validated
by
a
supplementary
questionnaire.
Results
During
22-24
years
follow-up,
10
915
incident
occurred.
The
multivariable
adjusted
hazard
ratios
for
1.31
(95%
confidence
interval
1.19
1.44)
five
year
increment
2.30
(1.88
2.83)
unhealthy
factor
(ever
low
quality,
activity,
overweight
obesity).
For
ratio
2.83
(2.15
3.73)
significant
additive
interaction
(P
<0.001).
proportions
17.1%
(14.0%
20.8%)
alone,
71.2%
(66.9%
75.8%)
11.3%
(7.3%
17.3%)
Conclusions
Among
female
nurses,
both
associated
higher
diabetes.
excess
combined
than
each
individual
factor.
These
findings
suggest
most
could
be
prevented
adhering
healthy
lifestyle,
benefits
greater
workers.
Journal of Biological Rhythms,
Journal Year:
2021,
Volume and Issue:
37(1), P. 3 - 28
Published: Dec. 30, 2021
The
various
non-standard
schedules
required
of
shift
workers
force
abrupt
changes
in
the
timing
sleep
and
light-dark
exposure.
These
result
disturbances
endogenous
circadian
system
its
misalignment
with
environment.
Simulated
night-shift
experiments
field-based
studies
both
indicate
that
is
resistant
to
adaptation
from
a
day-
night-oriented
schedule,
as
determined
by
lack
substantial
phase
shifts
over
multiple
days
centrally
controlled
rhythms,
such
those
melatonin
cortisol.
There
evidence
disruption
caused
work
results
not
only
between
external
cycle,
but
also
state
internal
desynchronization
levels
system.
This
case
rhythms
central
pacemaker
clock
genes
expression
tissues
peripheral
blood
mononuclear
cells,
hair
follicle
oral
mucosa
cells.
disruptive
effects
atypical
extend
beyond
profile
canonical
affects
other
transcripts
human
genome.
In
general,
after
several
living
at
night,
most
rhythmic
genome
remain
adjusted
day-oriented
dampened
group
amplitudes.
contrast
transcripts,
metabolomics
revealed
metabolites
hours
when
working
nights,
thus
leading
their
Altogether,
these
sleep-wake
emphasize
all-encompassing
impact
work,
can
contribute
increased
risk
medical
conditions.
Here,
we
review
latest
scientific
regarding
on
system,
alertness
shift-working
populations,
discuss
potential
clinical
impacts.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: May 17, 2021
Dietary
restriction
(DR)
decreases
body
weight,
improves
health,
and
extends
lifespan.
DR
can
be
achieved
by
controlling
how
much
and/or
when
food
is
provided,
as
well
adjusting
nutritional
composition.
Because
these
factors
are
often
combined
during
DR,
it
unclear
which
necessary
for
beneficial
effects.
Several
drugs
have
been
utilized
that
target
nutrient-sensing
gene
pathways,
many
of
change
expression
throughout
the
day,
suggesting
timing
drug
administration
critical.
Here,
we
discuss
dietary
pharmacological
interventions
promote
a
healthy
lifespan
influencing
energy
intake
circadian
rhythms.