Mechanism of Huaiqihuang in treatment of diabetic kidney disease based on network pharmacology, molecular docking and in vitro experiment DOI Creative Commons
Junwei Wang,

Guiqiao Ma,

Peipei Zhang

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(50), P. e36177 - e36177

Published: Dec. 15, 2023

This study aimed to investigate the active components, key targets, and potential molecular mechanisms Huaiqihuang (HQH) in treatment of diabetic kidney disease (DKD) through network pharmacology, docking, vitro experiments.The components targets HQH were obtained from TCMSP HERB databases. The DKD GeneCards, OMIM, DrugBank, TTD Protein interaction relationships STRING database, a protein was constructed using Cytoscape software. Gene ontology Kyoto Encyclopedia Genes Genomes enrichment analysis performed Metascape database. Molecular docking AutoDock software verify binding between compounds core target genes. In experiments conducted human renal proximal tubular epithelial cells various methods, such as CCK8, RT-PCR, immunofluorescence, western blot, evaluate effects on inflammatory factors, pathways.A total 48 ingredients, 168 HQH, 1073 obtained. A 118 438 biological processes, 187 signal pathways identified for DKD. indicated that may exert its therapeutic by regulating expression factors nuclear factor kappa B (NF-κB) signaling pathway. results showed β-sitosterol baicalein had highest affinity with AKT1, IL6, TNF, PTGS2, IL1B, CASP3, suggesting they be most effective ingredients experimental demonstrated could enhance viability inhibited high glucose, decrease levels reduce NF-κB-P65 (P < .01), inhibit NF-κB-p65 translocation, chemokine .01).HQH inhibiting NF-κB pathway, reducing level pro-inflammatory cytokines, alleviating glucose-induced injury cells.

Language: Английский

Sustainable Supply Chain Management in the Herbal Medicine Industry DOI

Ebiuwa Gladys Obahiagbon,

Matthew Chidozie Ogwu

Reference series in phytochemistry, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 29

Published: Jan. 1, 2023

Language: Английский

Citations

22
Lipid metabolism disorder in diabetic kidney disease DOI Creative Commons

Yi-Zhen Han,

Bo-Xuan Du,

Xingyu Zhu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 29, 2024

Diabetic kidney disease (DKD), a significant complication associated with diabetes mellitus, presents limited treatment options. The progression of DKD is marked by substantial lipid disturbances, including alterations in triglycerides, cholesterol, sphingolipids, phospholipids, droplets, and bile acids (BAs). Altered metabolism serves as crucial pathogenic mechanism DKD, potentially intertwined cellular ferroptosis, lipophagy, reprogramming, immune modulation gut microbiota (thus impacting the liver-kidney axis). elucidation these mechanisms opens new potential therapeutic pathways for management. This research explores link between disruptions onset.

Language: Английский

Citations

9
NF-ĸB axis in diabetic neuropathy, cardiomyopathy and nephropathy: A roadmap from molecular intervention to therapeutic strategies DOI Creative Commons

Aryan Rezaee,

Parham Rahmanian,

Amirreza Nemati

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29871 - e29871

Published: April 18, 2024

Diabetes mellitus (DM) is a metabolic illness defined by elevated blood glucose levels, mediating various tissue alterations, including the dysfunction of vital organs. can lead to many consequences that specifically affect brain, heart, and kidneys. These issues are known as neuropathy, cardiomyopathy, nephropathy, respectively. Inflammation acknowledged pivotal biological mechanism contributes development diabetes consequences. NF-κB modulates inflammation immune system at cellular level. Its abnormal regulation has been identified in several clinical situations, cancer, inflammatory bowel illnesses, cardiovascular diseases, Mellitus (DM). The purpose this review evaluate potential impact on complications associated with DM. Enhanced activity promotes inflammation, resulting harm compromised organ performance. Phytochemicals, which therapeutic molecules, potentially decline level, therefore alleviating progression problems correlated More importantly, be influenced factors, such TLR4 Highlighting these factors facilitate novel therapies future.

Language: Английский

Citations

6
Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy DOI Creative Commons

Fengzhao Liu,

Lijuan Zhao, Tao Wu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

As the quality of life improves, incidence diabetes mellitus and its microvascular complications (DMC) continues to increase, posing a threat people's health wellbeing. Given limitations existing treatment, there is an urgent need for novel approaches prevent treat DMC. Autophagy, pivotal mechanism governing metabolic regulation in organisms, facilitates removal dysfunctional proteins organelles, thereby sustaining cellular homeostasis energy generation. Anomalous states pancreatic β-cells, podocytes, Müller cells, cardiomyocytes, Schwann cells DMC are closely linked autophagic dysregulation. Natural products have property being multi-targeted can affect autophagy hence progression terms nutrient perception, oxidative stress, endoplasmic reticulum inflammation, apoptosis. This review consolidates recent advancements understanding pathogenesis via proposes perspectives on treating by either stimulating or inhibiting using natural products.

Language: Английский

Citations

5
Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF-β1/Smads signaling pathway DOI
Qiangsheng Li, Yifei Wang, Yan Jia

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112131 - 112131

Published: April 25, 2024

Language: Английский

Citations

5
Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application DOI Creative Commons
Qiqi Zhang,

Shiwan Hu,

Zishan Jin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 6, 2024

Affected by aging, the elderly diabetes patients have many pathological characteristics different from young people, including more complications, vascular cognitive impairment, osteoporosis, and sarcopenia. This article will explore their pathogenesis mechanism of Traditional Chinese medicine (TCM) intervention, use method systematic review to evaluate clinical application TCM in diabetes.

Language: Английский

Citations

4
Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy DOI Creative Commons
Yang Sun, Yanhong Zhao,

Yongxin Lu

et al.

International Urology and Nephrology, Journal Year: 2023, Volume and Issue: 56(4), P. 1449 - 1463

Published: Oct. 10, 2023

Abstract Objective The etiopathogenesis of diabetes nephropathy (DN) has not yet been fully clarified. Finding effective treatments to prevent renal failure in DN patients become the main focus research recent years. Circular RNA (circRNA) shown play a momentous role progression. Based on this, we aimed investigate potential mechanism by which urine-derived stem cell (USC)-derived exosome circRNA ATG7 (Exo-ATG7) mediates Methods Exosomes from USCs were isolated and identified. rat model was established intraperitoneally injecting 60 mg/kg streptozotocin. protein expression levels measured Western blot immunofluorescence. HE Masson staining used evaluate injury, related genes detected RT-qPCR. Results CircRNA significantly downregulated model, extracellular vesicles improved function reduced inflammation rats. However, after knocking down USCs-derived ATG7, improvement therapeutic effect rats lost. In addition, overexpression facilitated switching macrophages pro-inflammatory M1 phenotype anti-inflammatory M2 both vivo vitro. Mechanistically, upregulation can alleviate damage Importantly, promotes macrophage polarization regulating SOCS1/STAT3 signaling pathway through miR-4500. animal experiments also confirmed that USC cells, extracted exosome-treated could weaken exosomes. Conclusion Our results indicate USC-derived exosomal facilitates mediated miR-4500, thereby inhibiting

Language: Английский

Citations

9
Gut microbiota microbial metabolites in diabetic nephropathy patients: far to go DOI Creative Commons
Jianxiu Yu, Xin Chen,

Su-Gang Zang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 8, 2024

Diabetic nephropathy (DN) is one of the main complications diabetes and a major cause end-stage renal disease, which has severe impact on quality life patients. Strict control blood sugar pressure, including use renin–angiotensin–aldosterone system inhibitors, can delay progression diabetic but cannot prevent it from eventually developing into disease. In recent years, many studies have shown close relationship between gut microbiota imbalance occurrence development DN. This review discusses latest research findings correlation microbial metabolites in DN, manifestations DN patients, application diagnosis their role disease progression, so on, to elucidate prevention provide theoretical basis methods for clinical treatment.

Language: Английский

Citations

2
Mitochondrial dysfunction in diabetic nephropathy: insights and therapeutic avenues from traditional Chinese medicine DOI Creative Commons

Dan-mai Zhao,

Rui Zhong, Xiaotian Wang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 23, 2024

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus. The progressive damage to glomeruli, tubules, and interstitium in the kidneys can lead development chronic kidney disease (CKD) end-stage renal (ESRD). Most energy we need comes from mitochondria. Mitochondria are best known as sites for production respiratory ATP essential eukaryotic life. pathogenesis DN involves variety factors, such altered haemodynamics, oxidative stress, inflammation, studies animal models suggest that mitochondrial dysfunction plays an important role DN. Traditional Chinese medicine (TCM) has history more than 2,500 years rich experience remarkable efficacy treatment Recent have found TCM may great potential regulating This review will elucidate main causes relationship with DN, explore depth mechanisms protect by improving dysfunction. Current pharmacological treatments patients do not prevent inevitable progression ESRD. With herbs, expected be most promising candidate continue learn about incorporate current advances extraction techniques.

Language: Английский

Citations

2
Herbal therapeutics for chronic disease management DOI
Md. Helal Uddin Chowdhury, Md. Adnan

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 411 - 463

Published: Nov. 22, 2024

Language: Английский

Citations

0