Surgery, Journal Year: 2024, Volume and Issue: 176(4), P. 1233 - 1238
Published: Aug. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124481 - 124481
Published: July 23, 2024
Language: Английский
Citations
10
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133494 - 133494
Published: June 27, 2024
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 139920 - 139920
Published: Jan. 22, 2025
Language: Английский
Citations
1
Medicines, Journal Year: 2025, Volume and Issue: 12(1), P. 4 - 4
Published: Feb. 7, 2025
Vaccination represents a critical preventive strategy in the current global healthcare system, serving as an indispensable intervention against diverse pathogenic threats. Although conventional immunization relies predominantly on hypodermic needle-based administration, this method carries substantial limitations, including needle-associated fear, bloodborne pathogen transmission risks, occupational injuries among workers, waste management issues, and dependence trained medical personnel. Microneedle technology has emerged innovative vaccine delivery offering convenient, effective, minimally invasive administration. These microscale needle devices facilitate targeted antigen to epidermal dermal tissues, where abundant populations of antigen-presenting cells, specifically Langerhans dendritic provide robust immunological responses. Multiple research groups have extensively investigated microneedle-based vaccination strategies. This transdermal technique offers several advantages, notably circumventing cold-chain requirements enabling self-administration. Numerous preclinical investigations clinical trials demonstrated safety profile, immunogenicity, patient acceptance microneedle-mediated across applications. comprehensive review examines fundamental aspects immunization, principles, transcutaneous strategies, delivery-including classifications, barriers. Furthermore, addresses technical considerations, such treatment efficacy, application methodologies, wear duration, dimensional optimization, manufacturing processes, regulatory frameworks, sustainability followed by analysis future perspective technology.
Language: Английский
Citations
1
Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2596 - 2596
Published: Sept. 13, 2024
The nanofiber materials of three-dimensional spatial structure synthesized by electrospun have the characteristics high porosity, specific surface area, and similarity to natural extracellular matrix (ECM) human body. These are beneficial for absorbing wound exudate, effectively blocking invasion external bacteria, promoting cell respiration proliferation, which provides an ideal microenvironment healing. Moreover, dressings can flexibly load drugs according condition wound, further Recently, shown promising application prospects as medical in clinical. Based on current research, this article reviewed development history principles technology. Subsequently, based types base material, polymer-based dressing containing drug-releasing factors were discussed. Furthermore, skin tissue is highlighted. This review aims provide a detailed overview research nanomaterials healing, addressing challenges suggesting future directions advance field
Language: Английский
Citations
7
Small, Journal Year: 2023, Volume and Issue: 20(7)
Published: Oct. 8, 2023
Abstract The severe quality of life and economic burden imposed by non‐healing skin wounds, infection risks, treatment costs are affecting millions patients worldwide. To mitigate these challenges, scientists relentlessly seeking effective measures. In recent years, extracellular vesicles (EVs) have emerged as a promising cell‐free therapy strategy, attracting extensive attention from researchers. EVs mediate intercellular communication, possessing excellent biocompatibility stability. These features make potential tool for treating plethora diseases, including those related to wound repair. However, there is growing focus on the engineering overcome inherent limitations such low production, relatively fixed content, targeting capabilities natural EVs. This could improve both effectiveness specificity in repair treatments. light this, present review will introduce latest progress design methods experimental paradigms engineered applied Furthermore, it comprehensively analyze current clinical research status prospects within this field.
Language: Английский
Citations
11
Physiologia, Journal Year: 2024, Volume and Issue: 4(1), P. 81 - 99
Published: Feb. 8, 2024
When thinking of skin disease, cancer comes up almost immediately as an example. While the American Cancer Society lists 6 major types, National Institute Arthritis and Musculoskeletal Skin Diseases identifies 13 significant benign disorders, reflecting diversity conditions in dermatology. This topical review aims to provide overview pathophysiology these cancers disorders summarize conventional diagnostic methods current treatment approaches.
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 133005 - 133005
Published: June 12, 2024
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 134973 - 134973
Published: Aug. 24, 2024
Language: Английский
Citations
4
Frontiers in Chemical Engineering, Journal Year: 2025, Volume and Issue: 6
Published: Jan. 13, 2025
Wound healing represents a global public health problem when it is not treated correctly, which can cause complications for the patient, such as functional loss of an organ, amputation, and even death. At biological level, wound involves complex mechanism in immune system cellular biochemical cascades intervene coordinated manner, whose development occurs stages inflammation, proliferation, remodeling. Therefore, therapies have been developed to accelerate proven effective. However, factors diabetes mellitus limit process because causes alterations microvascular dysfunction, well inflammatory response greater oxidative stress. This reflected abnormal process; therefore, search compounds has become area interest. In this regard, medicinal plants used centuries treat wounds different cultures world. Hence, review documents main plant species Latin America due its great biodiversity numerous that are potentially important new active compounds. review, 62 families with studies were found, highlighting Fabaceae, Asteraceae Euphorbiaceae family. Additionally, 32 natural diverse structural nature effects evaluated vivo vitro models, essential studying pathogenesis tissue repair mechanism, detecting biomarkers, evaluate treatments. Currently, several models study process, including silico , vitro, models. On other hand, there no appropriate model determine effect, and, many cases, they combined provide sufficient scientific evidence. demonstrates potential region research into sources molecules. Nevertheless, still being studied findings allow generating viable alternatives solution problems associated healing.
Language: Английский
Citations
0