Lycium barbarum polysaccharide alleviates DSS-induced chronic ulcerative colitis by restoring intestinal barrier function and modulating gut microbiota

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(2)

Published: Dec. 7, 2023

Purpose This study examined the protective effects and mechanism of Lycium barbarum polysaccharides (LBP) in context intestinal barrier function microbiota mice with dextran sulfate sodium (DSS)-induced chronic ulcerative colitis (UC).

Language: Английский

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Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1−nuclear factor erythroid 2-related factor 2 (Keap1−Nrf2) protein−protein interaction inhibitors for ulcerative colitis management

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117384 - 117384

Published: Feb. 13, 2025

Language: Английский

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Mechanism of Action and Therapeutic Implications of Nrf2/HO-1 in Inflammatory Bowel Disease

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1012 - 1012

Published: Aug. 20, 2024

Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear erythroid 2 (NF-E2)-related (Nrf2) major transcriptional regulator antioxidant reactions. Heme oxygenase-1 (HO-1), gene regulated by Nrf2, one most critical cytoprotective molecules. In recent years, Nrf2/HO-1 has received widespread attention as regulatory pathway for intracellular defense against oxidative stress. It considered potential target treatment inflammatory bowel disease (IBD). This review highlights mechanism action and therapeutic significance IBD complications (intestinal fibrosis colorectal cancer (CRC)), well phytochemicals targeting IBD. The results suggest that effects on mainly involve following aspects: (1) Controlling to reduce intestinal inflammation injury; (2) Regulation flora repair mucosal barrier; (3) Prevention ferroptosis epithelial cells. However, due complex role Nrf2/HO-1, more nuanced understanding exact mechanisms involved way forward future.

Language: Английский

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Protective effect of andrographolide against ulcerative colitis by activating Nrf2/HO-1 mediated antioxidant response

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 29, 2024

Ulcerative colitis (UC) is a recurring inflammatory bowel disease, in which oxidative stress plays role its progression, and regulation of the oxidative/antioxidative balance has been suggested as potential target for treatment UC. The aim this study was to evaluate protective effect andrographolide against UC antioxidant properties by modulating nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Dextran sulfate sodium (DSS) -induced mice LPS-induced HT29 cell model were established uncover mechanisms andrographolide. ML385, Nrf2 inhibitor, used both models assess whether exerts through Nrf2/HO-1

Language: Английский

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p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF-κB/AP-1 pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155941 - 155941

Published: Aug. 6, 2024

Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease (IBD), presents with limited current drug treatment options. Consequently, the search for safe and effective UC prevention is imperative. Our prior studies have demonstrated that phenolic compound p-Hydroxybenzaldehyde (HD) from Nostoc commune, effectively mitigates intestinal inflammation. However, mechanisms underlying HD's anti-inflammatory effects remain unclear.

Language: Английский

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Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(3), P. 2007 - 2022

Published: April 4, 2024

Language: Английский

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Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116067 - 116067

Published: Dec. 26, 2023

Neuropathic pain, a chronic condition with high incidence, imposes psychological burdens on both patients and society. It is urgent to improve pain management develop new analgesic drugs. Traditional Chinese medicine has gained popularity as method for relief. Diosmetin (Dio) mainly found in herbal medicines effective antioxidant, anti-cancer, anti-inflammatory properties. There are few known mechanisms underlying the effectiveness of Dio treating neuropathic pain. However, complete understanding its therapeutic effect missing.

Language: Английский

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Li-Hong Tang alleviates dextran sodium sulfate-induced colitis by regulating NRF2/HO-1 signaling pathway and gut microbiota

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Ulcerative colitis (UC) is marked by recurring inflammation. Existing treatments are ineffective and may have toxic side effects. Thus, new therapeutic agents urgently needed. We studied the botanical formula "Li-Hong Tang (LHT)", which contains two main ingredients,

Language: Английский

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The Dual Role of NRF2 in Colorectal Cancer: Targeting NRF2 as a Potential Therapeutic Approach

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5985 - 6004

Published: Sept. 1, 2024

Colorectal cancer (CRC), as the third most common bisexual worldwide, requires urgent research on its underlying mechanisms and intervention methods. NRF2 is an important transcription factor involved in regulation of redox homeostasis, protein degradation, DNA repair, other processes, playing role cancer. In recent years, complex CRC has been continuously revealed: one hand, it exhibits a chemopreventive effect by protecting normal cells from oxidative stress, also protective malignant cells. Therefore, this article explores dual related signaling pathways CRC, including their chemical properties promoting effects occurrence, development, metastasis, chemotherapy resistance CRC. addition, focuses exploring ferroptosis, well drug modulators (activators inhibitors) targeting natural products, compounds, traditional Chinese medicine formulations.

Language: Английский

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Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1 - 15

Published: Jan. 1, 2025

Objective: The aim of this study is to investigate the protective effect Cannabidiol (CBD) on DSS-induced colitis in C57BL/6 mice and its related pathways. Methods: A mouse model ulcerative (US) was induced by DSS. Enzyme-linked immunosorbent assay (ELISA), quantitative reverse transcription polymerase-chain reaction (qRT-PCR), Western blot (WB) immunofluorescence (IF) were used identify key factors involved inflammatory response, oxidative stress intestinal fibrosis. In addition, we transfected si-RNA into CCD-18Co cells. Results: research suggests that CBD significantly improves inflammation up-regulating nuclear factor erythroid 2-related 2 (Nrf2) expression, inhibiting classical Nuclear Factor kappa-light-chain-enhancer activated B cells (NF-κb) pathway, release IL-6 (Interleukin), IL-1β, Tumor Necrosis Factor-α (TNF-α) other factors. At same time, plays an antioxidant role regulating Nrf2/ HO-1 (Heme Oxygenase-1) pathway activating activity. On hand, may regulate Transforming growth beta (TGF-β)/SMADs signaling expression TGF-β 1, thereby α-SMA, Collagen1, TIMP1 factors, thus playing anti-fibrotic role. Notably, when Nrf2 inhibited or lacking, loses above against colon injury. Conclusion: affects NF-κb Heme Oxygenase-1 (HO-1) (TGF-β)/SMAD Nrf2, reducing colonic improving progression Keywords: Ulcerative colitis, cannabidiol, fibrosis,

Language: Английский

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