Investigation of the Associations of Novel Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)—With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 9553 - 9553

Published: Aug. 23, 2022

Atherosclerosis, the underlying cause of coronary artery disease (CAD), has a significant inflammatory component. White blood cell count is an affordable and accessible way to assess systemic immune response, as it comprises many subgroups with distinct complex functions. Considering their multidirectional effect on atherosclerosis, new biomarkers integrating various leukocyte subgroups, Systemic Inflammatory Index (SII) Response (SIRI), were recently devised describe balance between inflammation reaction. This research aimed evaluate relationship intensity measured by these severity CAD assessed angiography diagnosis acute syndrome (ACS) or stable in 699 patients. SIRI, but not SII, was associated diagnosis, having highest values for patients ACS (STEMI), significantly higher than (p < 0.01). The SII SIRI observed three-vessel CAD. require further in-depth well-designed potential clinical setting.

Language: Английский

---

Association of the systemic immune-inflammation index with all-cause mortality in patients with arteriosclerotic cardiovascular disease

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 12, 2022

Systemic immune-inflammation index (SII), derived from blood cell counts of circulating platelets, neutrophils, and lymphocytes, has been identified as a novel inflammatory prognostic marker. However, the clinical value SII in patients with arteriosclerotic cardiovascular disease (ASCVD) had not further explored. Thus, this study is designed to explore associations mortality ASCVD individuals.All individuals aged ≥20 years were included National Health Nutritional Examination Surveys (NHANES) 2005-2014 followed for survival until 31 December 2019. Multivariable Cox analysis investigated between SII, evaluated continuous variable splines, categorical ones (quartiles), all-cause death. To demonstrate association mortality, subgroup analysis, restricted cubic spline along piecewise linear regression also conducted.A total 2,595 participants (57.8% men) included. During median 7.7 follow-up, 1,122 deaths due recorded. After adjusting multiple confounders, when compared quartile 1 (SII ln transform), those 4 46% increased risk death [hazard ratio (HR) = 1.46, 95% confidence interval (CI) 1.22-1.75]. As variable, each unit raised ln-SII was associated 24% (HR 1.24, CI 1.10-1.38). In model, relationship non-linear. The cutoff 6.57 higher than threshold point 1.25-fold mortality. No significant difference noted below points.An detected baseline United States population. Increased poor ASCVD.

Language: Английский

---

Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

European Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 54(2)

Published: Sept. 29, 2023

Abstract Background Systemic immune‐inflammation index (SII) is a novel inflammatory marker based on neutrophils, platelets and lymphocytes counts, which has potential prognostic value among coronary artery disease (CAD) patients as described by some observational studies. We aimed to provide higher‐certainty evidence verify the association of SII with poor outcomes CAD patients. Methods PubMed, Web Science, Embase, Ovid Scopus were searched find relevant literature exploring Hazard ratios (HRs) 95% confidence intervals (CIs) extracted from included pooled fixed‐effect or random‐effect model. Sensitivity analyses subgroup conducted detect source heterogeneity evaluate stability results. Results A total nine studies 15,832 participants included. The quantitative synthesis including eight 15,657 showed that high was related major adverse cardiovascular event in (HR CI: 2.36 [1.67, 3.33]). After eliminating adjusting for publication bias, above result still robust 1.67 [1.32, 2.12]). Additionally, we also demonstrated values all‐cause death, myocardial infarction stroke. Conclusion Higher

Language: Английский

---

Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1256 - 1256

Published: Feb. 22, 2024

(1) Background: The systemic inflammatory response index (SIRI; neutrophil count × monocyte/lymphocyte count), and the immune-inflammation (SII; platelet count/lymphocyte count) are recently proposed biomarkers to assess immune status. However, data on SIRI SII still relatively lacking do not definitively exhaustively define their role as predictors of an adverse prognosis in acute myocardial infarction (AMI). aim present study was evaluate determinants well prognostic power ST-elevation (STEMI). (2) Methods: A total 105 STEMI patients (74 males, 70 ± 11 years) were studied (median follow-up 54 25 months, 24 deaths). (3) Results: main creatinine brain natriuretic peptide (BNP) (multivariate regression). Patients with higher (>75th percentile, 4.9) 1257.5) had lower survival rates than those low SIRI/SII group (Kaplan–Meier analysis). Univariate Cox regression revealed that high associated mortality (HR: 2.6, 95% CI: 1.1–5.8, p < 0.05; 2.2, 1–4.9, ≤ 0.05, respectively); however, these associations lost significance after multivariate adjustment. (4) Conclusions: association significantly affected by confounding factors our population, especially BNP, which both indices outcome.

Language: Английский

---

Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center longitudinal study

Inflammation Research, Journal Year: 2022, Volume and Issue: 72(1), P. 149 - 158

Published: Nov. 9, 2022

Language: Английский

---

The Association between Serum Vitamin D Concentration and New Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response (SIRI)—In Patients with Ischemic Heart Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 4212 - 4212

Published: Oct. 10, 2022

The incidence of ischemic heart disease (IHD) increases every year. This cardiovascular has an inflammatory factor in its etiology due to different immune cells that influence atherogenesis. New biomarkers-the Systemic Inflammatory Index (SII) and the Response (SIRI)-attempt describe pro- anti-inflammatory balance quantify complex impact system on atherosclerosis, while vitamin D a multidirectional human body, including systems. Hence, objective this research was analyze association between SII SIRI serum concentrations patients with IHD. A significant correlation observed 25(OH)D whole group both biomarkers (SII SIRI) ACS but not stable role IHD complications new requires further well-designed, large-scale research.

Language: Английский

---

Association between systemic immune-inflammation index and chronic kidney disease: A population-based study

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(2), P. e0292646 - e0292646

Published: Feb. 8, 2024

Systemic immune-inflammation index (SII) is a new indicator of inflammation, and chronic kidney disease (CKD) has connection to inflammation. However, the relationship between SII CKD still unsure. The aim this study was whether there an association in adult US population.

Language: Английский

---

The Systemic Immune Inflammatory Response Index Can Predict the Clinical Prognosis of Patients with Initially Diagnosed Coronary Artery Disease

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 5069 - 5082

Published: Nov. 1, 2023

Recently, the systemic immune inflammatory response index (SIIRI), a novel and expanded marker, has been an independent predictor of lesion severity in patients with acute coronary syndrome (ACS). However, its predictive role initially diagnosed artery disease (CAD) remains to be explored.We evaluated 959 CAD undergoing initial intervention. Each patient had laboratory measurements, including blood cell counts, taken after admission before interventional treatment. The primary endpoint was major cardiovascular events (MACEs), defined as death, nonfatal myocardial infarction(MI), stroke. secondary endpoints included MACEs readmission for congestive heart failure(HF).During mean follow-up period 33.3±9.9 months, 229 (23.9%) were recorded. ROC curve analysis displayed that best cut-off value SIIRI predicting 247.17*1018/L2. Kaplan-Meier survival showed rate low group higher than high (P<0.001). Compared group, significantly risk (187 cases (39.53%) vs.42 (8.64%), P<0.001). Univariate multivariate Cox regression analyses levels independently associated occurrence percutaneous intervention (PCI) (adjusted hazard ratio [HR]: 3.808, 95% confidence interval [CI%]: 2.643-5.486, Adding conventional factor models improved MACEs.Elevated is adverse prognosis CAD. can simple practical identify high-risk PCI.

Language: Английский

---

Baicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro

Drug Design Development and Therapy, Journal Year: 2022, Volume and Issue: Volume 16, P. 3353 - 3364

Published: Sept. 1, 2022

To investigate the effect of baicalin on reactive oxygen species (ROS)/ NOD-like receptor protein 3 (NLRP3)/Caspase-1/gasdermin-D (GSDMD) inflammasome pathway and its related mechanism in regulating pyroptosis human renal tubular epithelial cells (HK-2) induced by contrast media.Iohexol was used to act HK-2 establish a cell model; signal genes were silenced, cytokines detected enzyme-linked immunosorbent assay (ELISA), viability, gene expression, expression evaluated double fluorescence staining flow cytometry. assess cytotoxicity caused agent; pretreated with different concentrations baicalin; then exposed iohexol again, relevant indicators tested again.After iohexol, NLRP3 markers NLRP3, interleukin (IL)-1β, IL-18 mRNA levels as well ASC, Caspase-1, GSDMD up-regulated. In addition, also significantly increased IL-18, IL-1β, lactate dehydrogenase (LDH), superoxide dismutase (SOD), malondialdehyde (MDA) release, cellular ROS levels. The results Annexin V-FITC/PI cytometry showed that level apoptosis increased. However, after intervention baicalin, changes above indexes stimulation inhibited.Exposure can induce through ROS/NLRP3/Caspase-1/GSDMD signaling pathway. Baicalin ameliorated iohexol-induced

Language: Английский

---

The association of systemic inflammatory biomarkers with non-alcoholic fatty liver disease: a large population-based cross-sectional study

Preventive Medicine Reports, Journal Year: 2023, Volume and Issue: 37, P. 102536 - 102536

Published: Dec. 7, 2023

The aim of this study was to explore the relationship between non-alcoholic fatty liver disease (NAFLD) and two blood inflammatory markers (systemic immune-inflammation (SII) index, system inflammation response index (SIRI)). National Health Nutrition Examination Survey data year 2017-2018 used for cross-sectional study. In order analyze association SII SIRI risk NAFLD, we multivariable logistic regression models, restricted cubic spline (RCS) plot, subgroup analysis data. total, there were 1,199 individuals who participated in survey. As shown by RCS linked with NAFLD a U-shaped pattern. With regard known confounding variables, when comparing lowest quartile, odds ratio 95% confidence interval prevalence across quartiles (0.89 (0.57, 1.41), 0.56 (0.35, 0.89) 1.01 (0.64, 1.59)), (0.77 (0.48, 1.23), 0.79 (0.50, 1.24) 0.94 (0.60, 1.47)), respectively. Additionally, also U-curve correlated among participants age ≥60 years, female, without hypertension, BMI ≥30 kg/m2. There is indicating that should be monitored dynamically.

Language: Английский

---