Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers

Pharmacological Research, Journal Year: 2020, Volume and Issue: 160, P. 105199 - 105199

Published: Sept. 14, 2020

Language: Английский

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The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Life Sciences, Journal Year: 2021, Volume and Issue: 268, P. 119005 - 119005

Published: Jan. 7, 2021

Language: Английский

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Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives

European Journal of Medicinal Chemistry Reports, Journal Year: 2021, Volume and Issue: 3, P. 100010 - 100010

Published: Oct. 15, 2021

Cancer is one of notorious diseases across the globe.Therapeutic approaches for cancer are often expensive and develop severe side effects, usually result comorbidities among survivors. Identifying novel therapies treatment will reduce in curing these diseases. It has been reported that flavones, a sub-class flavonoid can act as potent anticancer agent. Many experimental results displayed flavones modulate signal transduction pathways carcinogenesis. Flavones have found to control cell cycle progression, oxidative stress, angiogenesis metastasis alongwith some molecular ultimately prevent progression shown possess considerable preventive agents. As per reports, rich diet beneficial, decreased risk breast cancer, skin, digestive system, certain hematological malignancies prostate cancer. Apart from also effective improving other disease conditions such cardiovascular neurological Hence, prime target natural product drug discovery research. Based on existing findings, it concluded more extensive research needed understand detailed beneficial properties along with biochemical mechanisms drive medicinal properties.

Language: Английский

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Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis

Life Sciences, Journal Year: 2021, Volume and Issue: 270, P. 119006 - 119006

Published: Jan. 7, 2021

Language: Английский

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Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

The EPMA Journal, Journal Year: 2021, Volume and Issue: 12(4), P. 559 - 587

Published: Oct. 6, 2021

Inflammation is an essential pillar of the immune defense. On other hand, chronic inflammation considered a hallmark cancer initiation and progression. Chronic demonstrates potential to induce complex changes at molecular, cellular, organ levels including but not restricted stagnation impairment healing processes, uncontrolled production aggressive ROS/RNS, triggered DNA mutations damage, compromised efficacy repair machinery, significantly upregulated cytokine/chemokine release associated patho-physiologic protein synthesis, activated signaling pathways involved in carcinogenesis tumor progression, abnormal tissue remodeling, created pre-metastatic niches, among others. The anti-inflammatory activities flavonoids demonstrate clinically relevant as preventive therapeutic agents improve individual outcomes diseases linked low-grade systemic inflammation, cancers. To this end, are potent modulators pro-inflammatory gene expression being, therefore, great interest selectively suppressing molecular targets within pathways. This paper provides in-depth analysis properties flavonoids, highlights corresponding mechanisms targeted pathways, proposes treatment models for multi-level prevention framework predictive, preventive, personalized medicine (PPPM / 3PM). individualized profiling patient stratification implementing approaches. Most prominent examples presented proposed application flavonoid-conducted treatments overall management.The online version contains supplementary material available 10.1007/s13167-021-00257-y.

Language: Английский

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Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

Cancers, Journal Year: 2021, Volume and Issue: 13(16), P. 3934 - 3934

Published: Aug. 4, 2021

Gastrointestinal (GI) cancer is a prevalent global health disease with massive burden on care providers. Internal and external factors such as obesity, smoking, diet (red meat), low socioeconomic status infection Helicobacter pylori are the critical risk of GI cancers. Flavonoids natural phenolic compounds found abundantly in fruits vegetables. Upon ingestion, 90% flavonoids consumed require further enzymatic metabolism by gut microbiome to enhance their bioavailability absorption. Several epidemiological studies reported that consumption conversion microbes strongly associated reduced development. This review summarizes current knowledge human microbiome. It also addresses underlying anti-GI effects metabolic pathways apoptosis cellular proliferation. Overall, metabolites produced from flavonoid’s illustrate effects, but mechanisms action need clarification.

Language: Английский

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Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism

Cancers, Journal Year: 2021, Volume and Issue: 13(2), P. 188 - 188

Published: Jan. 7, 2021

Tumor cells develop several metabolic reprogramming strategies, such as increased glucose uptake and utilization via aerobic glycolysis fermentation of to lactate; these lead a low pH environment in which the cancer thrive evade apoptosis. These characteristics tumor are known Warburg effect. Adaptive alterations can be attributed mutations key enzymes transcription factors. The features phenotype may serve promising markers for early detection treatment tumors. Besides, glycolytic process tumors is reversible could represent therapeutic target. So-called mono-target therapies often unsafe ineffective, have high prevalence recurrence. Their success hindered by ability simultaneously multiple chemoresistance pathways. Therefore, agents that modify cellular targets, energy restriction target specifically, potential. Resveratrol, natural active polyphenol found grapes red wine used many traditional medicines, its components signaling pathways tumors, leading suppression cell proliferation, activation apoptosis, regression growth. Here, we describe current knowledge on various mechanisms resveratrol modulates metabolism, potential an imitator caloric restriction, capacity

Language: Английский

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10479 - 10479

Published: Sept. 9, 2022

In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.

Language: Английский

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Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

The EPMA Journal, Journal Year: 2022, Volume and Issue: 13(2), P. 315 - 334

Published: April 14, 2022

Breast cancer incidence is actually the highest one among all cancers. Overall breast management associated with challenges considering risk assessment and predictive diagnostics, targeted prevention of metastatic disease, appropriate treatment options, cost-effectiveness approaches applied. Accumulated research evidence indicates promising anti-cancer effects phytochemicals protecting cells against malignant transformation, inhibiting carcinogenesis spread, supporting immune system increasing effectiveness conventional therapies, others. Molecular sub-/cellular mechanisms are highly complex affecting several pathways considered potent targets for advanced diagnostics cost-effective treatments. Demonstrated affects, therefore, clinically relevant improving individual outcomes might be applicable to primary (protection initial development), secondary potential disease tertiary (towards cascading complications) care. However, a detailed data analysis essential adapt algorithms individuals' patients' needs. Consequently, concepts patient stratification, prevention, treatments tailored individualized profile instrumental application natural substances improve overall benefiting affected individuals society at large.

Language: Английский

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Antioxidants in brain tumors: current therapeutic significance and future prospects

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Oct. 28, 2022

Brain cancer is regarded among the deadliest forms of worldwide. The distinct tumor microenvironment and inherent characteristics brain cells virtually render them resistant to majority conventional advanced therapies. Oxidative stress (OS) a key disruptor normal homeostasis involved in carcinogenesis different cancers. Thus, antioxidants may inhibit tumorigenesis by preventing OS induced various oncogenic factors. Antioxidants are hypothesized initiation endorsing DNA repair suppressing progression creating an energy crisis for preneoplastic cells, resulting antiproliferative effects. These effects referred as chemopreventive mediated antioxidant mechanism. In addition, minimize chemotherapy-induced nonspecific organ toxicity prolong survival. also support prooxidant chemistry that demonstrate chemotherapeutic potential, particularly at high or pharmacological doses trigger promoting free radical production, which essential activating cell death pathways. A growing body evidence revealed roles exogenous adjuvants their ability reverse chemoresistance. this review, we explain influences endogenous on cancers with reference roles. role metabolic reprogramming influence downstream signaling events suppressor gene mutations critically discussed. Finally, review both pro- anticancer mechanisms molecules killing neoplastic inhibiting recurrence followed treatments. requirements treatment under conditions discussed along reasons behind conflicting outcomes reports. mention influencing factors regulate pharmacology treatment. conclusion, achieve consistent clinical treatments cancers, rigorous mechanistic studies required respect types, forms, stages tumors. concomitant regimens need adequate consideration.

Language: Английский

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