The long and short non-coding RNAs modulating EZH2 signaling in cancer

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 2, 2022

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate developmental and biological processes their abnormal expression affects cancer progression. These can function as upstream mediators different signaling pathways enhancer zeste homolog 2 (EZH2) is among them. Briefly, EZH2 belongs to PRCs exert functional roles cells due its methyltransferase activity. gene via inducing H3K27me3. In the present review, our aim provide mechanistic discussion ncRNAs role regulating cancers. MiRNAs dually induce/inhibit affect downstream targets such Wnt, STAT3 EMT. Furthermore, miRNAs regulate therapy response affecting signaling. It noteworthy that reduce miRNA by binding promoter exerting Small-interfering (siRNA) short-hairpin (shRNA) synthetic, short capable reducing suppressing LncRNAs mainly targeting miRNAs. lncRNAs induce modulating expression. Circular (CircRNAs), like lncRNAs, areas discussed review focus on molecular leading clinical translation.

Language: Английский

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The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Sept. 3, 2021

Although chemotherapy can improve the overall survival and prognosis of cancer patients, chemoresistance remains an obstacle due to diversity, heterogeneity, adaptability environmental alters in clinic. To determine more possibilities for therapy, recent studies have begun explore changes metabolism, especially glycolysis. The Warburg effect is a hallmark that refers preference cells metabolize glucose anaerobically rather than aerobically, even under normoxia, which contributes chemoresistance. However, association between glycolysis molecular mechanisms glycolysis-induced unclear. This review describes mechanism from aspects process, signaling pathways, tumor microenvironment, their interactions. understanding how induces may provide new targets concepts therapy.

Language: Английский

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Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: July 1, 2022

Abstract Background One of the most malignant tumors in men is prostate cancer that still incurable due to its heterogenous and progressive natures. Genetic epigenetic changes play significant roles development. The RNA molecules with more than 200 nucleotides length are known as lncRNAs these factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional levels. LncRNAs vital biological functions cells pathological events, hence their undergoes dysregulation. Aim review role alterations development emphasized here. Therefore, were chosen for this purpose level interaction other signaling networks progression examined. Key scientific concepts aberrant has been well-documented rate tumor regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt PTEN, among molecular pathways. Furthermore, radio-resistance chemo-resistance features cells. Overexpression tumor-promoting such HOXD-AS1 CCAT1 can result drug resistance. Besides, induce immune evasion upregulating PD-1. Pharmacological compounds quercetin curcumin have applied targeting lncRNAs. siRNA tool reduce thereby suppressing progression. Prognosis diagnosis clinical course be evaluated by exosomal lncRNA-p21 investigated serum patients a reliable biomarker.

Language: Английский

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Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

Molecules, Journal Year: 2021, Volume and Issue: 26(8), P. 2382 - 2382

Published: April 19, 2021

The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment cancer patients, it great importance reveal the molecular pathways mechanisms involved chemoresistance. Cisplatin (CP) platinum-containing drug with anti-tumor activity against different cancers both pre-clinical clinical studies. However, resistance has restricted its potential patients. CP can promote levels free radicals, particularly reactive oxygen species (ROS) induce cell death. Due double-edged sword role ROS as pro-survival or pro-death mechanism, result resistance. In present review, association sensitivity/resistance discussed, particular, how pathways, upstream downstream targets, affect response cells chemotherapy. Furthermore, compounds, such curcumin, emodin, chloroquine that regulate related increasing sensitivity are described. Nanoparticles provide co-delivery agents by mediating photodynamic therapy, overgeneration trigger sensitivity. Genetic tools, small interfering RNA (siRNA) down-regulate HIF-1α Nrf2 levels, leading Considering relationship between chemotherapy, translating these findings clinic pave way for

Language: Английский

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Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy

Life Sciences, Journal Year: 2021, Volume and Issue: 277, P. 119430 - 119430

Published: March 28, 2021

Language: Английский

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Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10244 - 10244

Published: Sept. 6, 2022

Polyphenols represent a structural class of mainly natural organic chemicals that contain multiple phenol units. The beneficial properties polyphenols have been extensively studied for their antitumor, anti-inflammatory, and antibacterial effects, but nowadays, medical applications are starting to be extended many other due prebiotic role impact on the microbiota. This review focused use in cancer treatment. Their antineoplastic effects demonstrated various studies when they were tested numerous lines some vivo models. A431 SCC13 human skin cell treated with EGCG presented reduced viability enhanced death inactivation β-catenin signaling. Additionally, resveratrol showed great potential against breast its ability exert both anti-estrogenic estrogenic (based concentration) because it has high affinity estrogen receptors ERα Erβ. can combined different classical cytostatic agents enhance therapeutic cells also protect healthy from aggressiveness antitumor drugs anti-inflammatory properties. For instance, curcumin reported reduce gastrointestinal toxicity associated chemotherapy. In case 5-FU-induced, by increasing intestinal permeability inhibiting mucosal damage. Co-administration doxorubicin induced liver cells. inhibit autophagic activity stop hepatoma Hep3B proliferation symbiotic approach is well-known practice including

Language: Английский

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Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2056 - 2056

Published: Nov. 29, 2023

Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in oncological applications phytochemicals, particularly polyphenols, resveratrol-a naturally occurring polyphenolic stilbene derivative-has emerged as a candidate interest. This review analyzes pleiotropic anti-cancer effects resveratrol, including its modulation apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, metastasis, interaction with cancer stem cells tumor microenvironment. The resveratrol on mitochondrial functions, which are crucial development, also discussed. Future research directions identified, elucidation specific molecular targets, facilitate clinical translation prevention therapy.

Language: Английский

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Resveratrol as sensitizer in colorectal cancer plasticity

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(1), P. 55 - 85

Published: July 29, 2023

Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that be linked several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition the sentinel gene p53, apoptosis. As consequence, tumor cells escape effectiveness chemotherapeutic agents. This underscores need for cross-target therapeutic approaches are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize overcome standard drugs. In recent years, scientists have been searching natural compounds used chemosensitizers addition conventional medications synergistic CRC. Resveratrol, polyphenolic phytoalexin found various fruits vegetables such peanuts, berries, red grapes, is one most effective chemopreventive Abundant vitro vivo studies shown resveratrol, interaction with drugs, chemosensitizer CRC agents thus prevents drug by modulating pathways, transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, The ability resveratrol modify subcellular may suppress plasticity reversal critical parameters understanding its anti-cancer effects. this review, we focus on chemosensitizing properties and, thus, potential importance additive ongoing treatments. Graphical abstract

Language: Английский

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Resveratrol Modulates Chemosensitisation to 5-FU via β1-Integrin/HIF-1α Axis in CRC Tumor Microenvironment

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4988 - 4988

Published: March 5, 2023

Frequent development of resistance to chemotherapeutic agents such as 5-flourouracil (5-FU) complicates the treatment advanced colorectal cancer (CRC). Resveratrol is able utilize β1-integrin receptors, strongly expressed in CRC cells, transmit and exert anti-carcinogenic signals, but whether it can also these receptors overcome 5-FU chemoresistance cells has not yet been investigated. Effects knockdown on anti-cancer capabilities resveratrol were investigated HCT-116 5-FU-resistant HCT-116R tumor microenvironment (TME) with 3D-alginate well monolayer cultures. increased cell sensitivity by reducing TME-promoted vitality, proliferation, colony formation, invasion tendency mesenchymal phenotype including pro-migration pseudopodia. Furthermore, impaired favor more effective utilization down-regulating TME-induced inflammation (NF-kB), vascularisation (VEGF, HIF-1α) stem production (CD44, CD133, ALDH1), while up-regulating apoptosis (caspase-3) that was previously inhibited TME. These mechanisms largely abolished antisense oligonucleotides against (β1-ASO) both lines, indicating particular importance for 5-FU-chemosensitising effect resveratrol. Lastly, co-immunoprecipitation tests showed targets modulates TME-associated β1-integrin/HIF-1α signaling axis cells. Our results suggest first time utility related chemosensitization overcoming resveratrol, underlining its potential supportive applications treatment.

Language: Английский

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Soy protein isolate-polyguluronate nanoparticles loaded with resveratrol for effective treatment of colitis

Food Chemistry, Journal Year: 2023, Volume and Issue: 410, P. 135418 - 135418

Published: Jan. 5, 2023

Language: Английский

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