Chronic constipation and gut microbiota: current research insights and therapeutic implications DOI
Xiaoqian Xu, Yali Wang,

Yiyan Long

et al.

Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Abstract Chronic constipation is a prevalent clinical condition. Its etiology and pathogenesis have not yet been fully understood. In recent years, mounting evidence suggests close association between chronic intestinal dysbiosis, including alterations in the colony structure metabolites, as well modulation of bowel movements via brain–gut–microbiota axis. With deepening related research, probiotic-related therapies are expected to become potential first-line treatment for future. this review, we summarize current research insights into intricate relationships gut microbiota briefly discuss several different approaches treating constipation. The findings from review may advance our understanding pathological mechanisms underlying and, ultimately, translate them improvements patient care.

Language: Английский

Lysimachia christinae polysaccharide attenuates diet-induced hyperlipidemia via modulating gut microbes-mediated FXR–FGF15 signaling pathway DOI

Yong-Fei Zhou,

Jiaojiao Nie, Chao Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 248, P. 125725 - 125725

Published: July 6, 2023

Language: Английский

Citations

19
The Role of Gut Microbiota-Derived Lithocholic Acid, Deoxycholic Acid and Their Derivatives on the Function and Differentiation of Immune Cells DOI Creative Commons

Yoshimitsu Kiriyama,

Hiromi Nochi

Microorganisms, Journal Year: 2023, Volume and Issue: 11(11), P. 2730 - 2730

Published: Nov. 8, 2023

A wide variety and large number of bacterial species live in the gut, forming gut microbiota. Gut microbiota not only coexist harmoniously with their hosts, but they also induce significant effects on each other. The composition can be changed due to environmental factors such as diet antibiotic intake. In contrast, alterations have been reported a diseases, including intestinal, allergic, autoimmune diseases cancer. metabolize exogenous dietary components ingested from outside body produce short-chain fatty acids (SCFAs) amino acid metabolites. Unlike SCFAs metabolites, source bile (BAs) produced by is endogenous BAs liver. generate secondary acids, lithocholic (LCA), deoxycholic (DCA), derivatives, which recently shown play important roles immune cells. This review focuses current knowledge role LCA, DCA, derivatives

Language: Английский

Citations

18
The oral-gut microbiome axis in inflammatory bowel disease: from inside to insight DOI Creative Commons
Aili Wang,

Zihan Zhai,

Yiyun Ding

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Inflammatory bowel disease (IBD) is an idiopathic and persistent inflammatory illness of the bowels, leading to a substantial burden on both society patients due its high incidence recurrence. The pathogenesis IBD multifaceted, partly attributed imbalance immune responses toward gut microbiota. There correlation between severity in oral microbiota, which has been discovered recent research highlighting role microbes development IBD. In addition, various conditions, such as angular cheilitis periodontitis, are common extraintestinal manifestations (EIMs) associated with colonic inflammation. However, it still unclear exactly how microbiota contributes This review sheds light probable causal involvement intestinal inflammation by providing overview evidence, developments, future directions regarding relationship Changes can serve markers for IBD, aiding early diagnosis predicting progression. Promising advances probiotic-mediated microbiome modification antibiotic-targeted eradication specific pathogens hold potential prevent

Language: Английский

Citations

6
Bear bile powder ameliorates type 2 diabetes via modulation of metabolic profiles, gut microbiota, and metabolites DOI Creative Commons

Xing-Ling Chen,

Ke Cai, Wen Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 4, 2023

Introduction: Bear bile powder (BBP) is widely used in the clinic and has a hypoglycemic effect, but its mechanism not clear. Methods: In this study, type 2 diabetes mellitus (T2DM) rats induced by high-sugar high-fat diet combined with streptozotocin were given BBP, biochemical indexes, pathological sections, metabonomics, intestinal microbiota (IM) short-chain fatty acids (SCFAs) determined. Results: The results showed that BBP could reduce blood glucose, relieve inflammation, insulin resistance, lipid metabolism disorder, alleviate tissue damage of liver, spleen, kidney, pancreas T2DM rats. It worth noting can reverse changes urine metabolites rats, which are mainly related to tryptophan metabolism, pentose glucuronate interconversions, starch sucrose glycerophospholipid metabolism. addition, restored IM disorder decreased abundance Allobaculum , Blautia Dubosiella Anaerostipes enriched Lactobacillus Romboutsia UCG-005 norank_f__Eggerthellaceae increased concentration SCFAs contents. Discussion: These findings suggest may improve regulating multiple metabolic pathways, composition, levels.

Language: Английский

Citations

13
The Black Box Orchestra of Gut Bacteria and Bile Acids: Who Is the Conductor? DOI Open Access

Soumia Majait,

Max Nieuwdorp,

Marleen Kemper

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1816 - 1816

Published: Jan. 17, 2023

Over the past decades potential role of gut microbiome and bile acids in type 2 diabetes mellitus (T2DM) has been revealed, with a special reference to low bacterial alpha diversity. Certain acid effects on bacteria concern cytotoxicity, or case microbiome, bacteriotoxicity. Reciprocally, plays key regulating pool by influencing conversion (de)conjugation primary into secondary acids. Three main groups enzymes responsible for are salt hydrolases (BSHs), hydroxysteroid dehydrogenases (HSDHs) encoded inducible (Bai) operon genes. Interventions such as probiotics, antibiotics fecal transplantation can impact levels. Further evidence reciprocal interaction between microbiota comes from multitude nutritional interventions including macronutrients, fibers, prebiotics, specific individual products diets. Finally, anatomical changes after bariatric surgery important because their metabolic effects. The heterogeneity studies, diseases, species (epi)genetic influences nutrition may challenge establishing detailed that aim tackle

Language: Английский

Citations

13
Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases DOI Open Access

Yoshimitsu Kiriyama,

Hiromi Nochi

Genes, Journal Year: 2023, Volume and Issue: 14(4), P. 825 - 825

Published: March 29, 2023

Bile acids (BAs) are amphiphilic steroidal molecules generated from cholesterol in the liver and facilitate digestion absorption of fat-soluble substances gut. Some BAs intestine modified by gut microbiota. Because a variety ways different types bacteria present microbiota, changes microbiota can affect metabolism host. Although most absorbed transferred to liver, some systemic circulation. Furthermore, have also been detected brain thought migrate into through known physiological functions acting as ligands for various nuclear cell-surface receptors, found act on mitochondria autophagy cell. This review focuses their roles intracellular organelles neurodegenerative diseases.

Language: Английский

Citations

13
The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review DOI Creative Commons
Chen Sun,

Dongzi Zhu,

Qi Zhu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 9, 2024

Autoimmune hepatitis (AIH) is a chronic inflammatory disease of the liver that mediated by autoimmunity and has complex pathogenesis. Its prevalence increased globally. Since first organ to be exposed harmful substances, such as gut-derived intestinal microbiota its metabolites, gut health closely related health, "liver-gut axis" allows abnormalities in influence development liver-related diseases AIH. Changes composition resultant disruption barrier microbial transport are involved multiple ways immune homeostasis inflammation, thereby influencing In terms mechanisms immune, or which decreased secondary bile acids, short-chain fatty acids (SCFAs), polyamines, lipopolysaccharide (LPS), branched-chain amino (BCAA), tryptophan metabolite, acid, can disrupt activating various cells immune-related signaling pathways, resulting aberrant activation system. Clarifying this mechanism significant clinical implications for treatment AIH with drugs target pathways. Therefore, narrative review summarizes progress exploring involvement pathogenesis AIH, aim helping improve precise targeting therapeutic treatments against benefit treatment.

Language: Английский

Citations

5
Laminaria japonica Polysaccharide Regulates Fatty Hepatosis Through Bile Acids and Gut Microbiota in Diabetes Rat DOI
Bo Zhang,

Jiacai Wang,

Xiaoxue Chen

et al.

Marine Biotechnology, Journal Year: 2024, Volume and Issue: 26(6), P. 1165 - 1178

Published: Aug. 29, 2024

Language: Английский

Citations

5
Diversity of the microbiota communities found in the various regions of the intestinal tract in healthy individuals and inflammatory bowel diseases DOI Creative Commons
Samuel Adefisoye Lawal, Athalia Voisin,

Hana Olof

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 2, 2023

The severe and chronic inflammatory bowel diseases (IBD), Crohn disease ulcerative colitis, are characterized by persistent inflammation gut damage. There is an increasing recognition that the microbiota plays a pivotal role in IBD development progression. However, studies of complete composition (bacteria, fungi, viruses) from precise locations within remain limited. In particular, have focused primarily on bacteriome, with available methods limiting evaluation mycobiome (fungi) virome (virus). Furthermore, while different segments small large intestine display functions (

Language: Английский

Citations

12
Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain DOI Creative Commons
Ali Shahbazi, Ali Sepehrinezhad,

Edris Vahdani

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1272 - 1272

Published: April 25, 2023

A common neuropsychiatric complication of advanced liver disease, hepatic encephalopathy (HE), impacts the quality life and length hospital stays. There is new evidence that gut microbiota plays a significant role in brain development cerebral homeostasis. Microbiota metabolites are providing avenue therapeutic options for several neurological-related disorders. For instance, composition blood-brain barrier (BBB) integrity altered HE variety clinical experimental studies. Furthermore, probiotics, prebiotics, antibiotics, fecal transplantation have been shown to positively affect BBB disease models potentially extendable by targeting microbiota. However, mechanisms underlie dysbiosis its effects on still unclear HE. To this end, aim review was summarize disruption possible mechanism.

Language: Английский

Citations

11