Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
29(11), P. 804 - 823
Published: Dec. 26, 2022
Abstract:
Edible
mushrooms
have
been
classified
as
“next-generation
food”
due
to
their
high
nutritional
value
coupled
with
biological
and
functional
potential.
The
most
extensively
studied
reported
mushroom
macromolecules
are
polysaccharides.
However,
macrofungi
proteins
peptides
also
a
representative
significant
bioactive
group.
Several
factors
such
species,
substrate
composition
harvest
time
significantly
impact
the
protein
content,
typically
ranging
between
19
35%
on
dry
weight
basis.
Proteins
work
based
shape
structure.
Numerous
extraction
methods,
including
chemical
non-conventional,
implications
yield
stability
will
be
discussed.
Beyond
potential,
great
advantage
of
is
uniqueness,
they
often
differ
from
animal,
vegetable,
microbial
proteins.
According
recently
published
reports,
relevant
include
lectins,
fungal
immunomodulatory
proteins,
ubiquitin-like
possessing
enzymatic
activity
ribonucleases
laccases,
other
enzymes
ergothioneine.
These
antioxidant,
antiviral,
antifungal,
antibacterial,
antihypertensive,
immunomodulatory,
antitumour,
antihypercholesterolemic
or
antihyperlipidemic,
antidiabetic
anti-inflammatory
properties,
which
improved
research
interest
contributed
increase
market
value.
This
review
provides
an
overview
biochemical
properties
main
groups
in
edible
mushrooms,
explicitly
focusing
biomedical
Although
rich
source
various
many
these
molecules
yet
identified
characterised.
Accordingly,
it
crucial
identify
characterise
new
origin,
opens
opportunity
for
further
investigation
bioactives
food,
nutraceutical,
medicinal
applications.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Feb. 7, 2023
Grifola
frondosa
is
an
edible
medicinal
mushroom
that
has
been
proven
to
have
a
variety
of
health
benefits.
The
main
active
ingredients
this
are
polysaccharides.
In
study,
ultrasonic-assisted
extraction
was
used
obtain
crude
polysaccharides
(GFPs).
Then,
purified
GFP
obtained
after
purification.
optimum
conditions
were
time
71
min,
temperature
90°C
in
solid-to-liquid
ratio
1:37
g/mL,
and
ultrasonic
power
500
W.
using
DEAE-52
Sephadex
G-100.
structural
characterization
performed
Fourier
transform
infrared
spectroscopy
(FT-IR),
X-ray
diffraction
(XRD),
ion
chromatography
(IC),
ultraviolet
(UV)
visible
photometry.
morphology
analyzed
by
scanning
electron
microscopy
(SEM),
thermogravimetric
differential
calorimetry
(TG-DSC),
Congo
red
testing.
addition,
the
administration
oxazolone
(OXZ)-induced
ulcerative
colitis
(UC)
mice
found
prevent
weight
loss.
Different
doses
(80,
160,
320
mg/kg
body
weight)
used,
sulfapyridine
(SASP)
as
positive
control
(370
for
treatment
OXZ-induced
UC.
After
treatment,
killed,
blood
colon
tissue
samples
collected.
decreases
length
levels
leukocytes,
platelets,
neutrophils
UC
mice.
Moreover,
also
decreased
expression
pro-inflammatory
cytokines
[tumor
necrosis
factor
(TNF)-α
interleukin
(IL)-1
β],
increased
IL-10,
reduced
injury
results
showed
Under
these
conditions,
predicted
polysaccharide
yield
21.72%,
actual
rate
21.13%.
composition
(molar
ratio)
composed
fucose
(0.025),
glucosamine
hydrochloride
(0.004),
galactose
(0.063),
glucose
(0.869),
mannose
(0.038).
typical
absorption
peak,
extracted
ultrasound-assisted
protocol
mainly
β-glucan.
These
indicate
could
reduce
intestinal
inflammation
promising
candidate
UC,
with
potential
development
food
supplement
improve
diseases.
New Zealand Journal of Botany,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 85
Published: July 22, 2024
Ganoderma,
a
genus
of
mushrooms
known
for
its
long
history
medicinal
use,
has
gained
increasing
attention
in
recent
years
due
to
potential
health
benefits.
This
review
delves
into
the
bioactive
compounds
found
Ganoderma
and
elucidates
intricate
mechanisms
underlying
immunomodulatory
anti-tumour
activities.
The
diverse
health-promoting
effects
can
be
attributed
decadent
array
compounds,
notably
polysaccharides,
triterpenoids,
which
play
pivotal
role.
ability
mushroom
modulate
immune
system,
enhancing
activity
cells,
such
as
natural
killer
cells
macrophages,
is
central
focus.
Furthermore,
we
explore
how
exerts
through
induction
apoptosis,
inhibition
angiogenesis,
interference
with
various
signalling
pathways
critical
cancer
cell
growth
metastasis.
As
research
this
area
continues
evolve,
comprehensive
understanding
supplement
role
promoting
well-being
emerging,
offering
promising
avenues
further
investigation
application
healthcare.
Antibiotics,
Journal Year:
2021,
Volume and Issue:
10(12), P. 1444 - 1444
Published: Nov. 25, 2021
Lung
diseases
such
as
asthma,
chronic
obstructive
pulmonary
diseases,
and
pneumonia
are
causing
many
global
health
problems.
The
COVID-19
pandemic
has
directed
the
scientific
community's
attention
toward
performing
more
research
to
explore
novel
therapeutic
drugs
for
diseases.
Herein,
gas
chromatography
coupled
with
mass
spectrometry
tentatively
identified
44
compounds
in
frankincense
ethanol
extract
(FEE).
We
investigated
antibacterial
antibiofilm
effects
of
FEE
against
Pseudomonas
aeruginosa
bacteria,
isolated
from
patients
respiratory
infections.
In
addition,
its
vitro
immunomodulatory
activity
was
explored
by
detection
gene
expression
tumor
necrosis
factor-α
(TNF-α),
interleukin-6
(IL-6),
nitric
oxide
synthase
(iNOS),
cycloxygenase-2
(COX-2),
nuclear
factor
kappa-B
(NF-κB)
lipopolysaccharide
(LPS)-induced
peripheral
blood
mononuclear
cells
(PBMC).
anticancer
A549
lung
cancer
cell
line
human
skin
fibroblast
(HSF)
normal
studied.
Moreover,
vivo
protective
potential
histologically
immunohistochemically
mice
using
a
benzo(a)pyrene
induced
damage
model.
exhibited
activities
besides
significant
inhibition
TNFα,
IL-6,
NF-κB.
also
exerted
cytotoxic
effect
line.
Histological
immunohistochemical
investigations
morphometric
analysis
mean
area
percentage
color
intensity
positive
TNF-α,
COX-2,
NF-κB
Bcl-2
reactions
revealed
FEE.
This
study
outlined
promising
oleoresin
obtained
B.
dalzielii
treatment
different
Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
29(11), P. 804 - 823
Published: Dec. 26, 2022
Abstract:
Edible
mushrooms
have
been
classified
as
“next-generation
food”
due
to
their
high
nutritional
value
coupled
with
biological
and
functional
potential.
The
most
extensively
studied
reported
mushroom
macromolecules
are
polysaccharides.
However,
macrofungi
proteins
peptides
also
a
representative
significant
bioactive
group.
Several
factors
such
species,
substrate
composition
harvest
time
significantly
impact
the
protein
content,
typically
ranging
between
19
35%
on
dry
weight
basis.
Proteins
work
based
shape
structure.
Numerous
extraction
methods,
including
chemical
non-conventional,
implications
yield
stability
will
be
discussed.
Beyond
potential,
great
advantage
of
is
uniqueness,
they
often
differ
from
animal,
vegetable,
microbial
proteins.
According
recently
published
reports,
relevant
include
lectins,
fungal
immunomodulatory
proteins,
ubiquitin-like
possessing
enzymatic
activity
ribonucleases
laccases,
other
enzymes
ergothioneine.
These
antioxidant,
antiviral,
antifungal,
antibacterial,
antihypertensive,
immunomodulatory,
antitumour,
antihypercholesterolemic
or
antihyperlipidemic,
antidiabetic
anti-inflammatory
properties,
which
improved
research
interest
contributed
increase
market
value.
This
review
provides
an
overview
biochemical
properties
main
groups
in
edible
mushrooms,
explicitly
focusing
biomedical
Although
rich
source
various
many
these
molecules
yet
identified
characterised.
Accordingly,
it
crucial
identify
characterise
new
origin,
opens
opportunity
for
further
investigation
bioactives
food,
nutraceutical,
medicinal
applications.
