Journal of Umm Al-Qura University for Applied Sciences,
Journal Year:
2023,
Volume and Issue:
9(3), P. 360 - 377
Published: May 10, 2023
Abstract
Fungal
infections
(mycoses)
represent
a
major
health
issue
in
humans.
They
have
emerged
as
global
concern
for
medical
professionals
by
causing
high
morbidity
and
mortality.
approximately
impact
one
billion
individuals
per
annum
account
1.6
million
deaths.
The
diagnosis
of
Candida
is
challenging
task.
Laboratory-based
species
identification
techniques
(molecular,
commercial,
conventional)
been
reviewed
summarized.
This
review
aims
to
discuss
the
mycoses
history,
taxonomy,
pathogenicity,
virulence
characteristics.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(12), P. 2013 - 2013
Published: June 10, 2022
The
current
work
concentrated
on
the
green
synthesis
of
silver
nanoparticles
(AgNPs)
through
use
aqueous
Citruslimon
zest
extract,
optimizing
different
experimental
factors
required
for
formation
and
stability
AgNPs.
preparation
was
confirmed
by
observation
color
change
mixture
nitrate,
after
addition
plant
from
yellow
to
a
reddish-brown
colloidal
suspension
established
detecting
surface
plasmon
resonance
band
at
535.5
nm,
utilizing
UV-Visible
analysis.
optimum
conditions
were
found
be
1
mM
nitrate
concentration,
1:9
ratio
extract
mixture,
4
h
incubation
period.
Fourier
transform
infrared
spectroscopy
spectrum
indicated
that
phytochemicals
compounds
present
in
Citrus
limon
had
fundamental
effect
production
AgNPs
as
bio-reducing
agent.
morphology,
size,
elemental
composition
investigated
zeta
potential
(ZP),
dynamic
light
scattering
(DLS),
SEM,
EDX,
X-ray
diffraction
(XRD),
transmission
electron
microscopy
(TEM)
analysis,
which
showed
crystalline
spherical
nanoparticles.
In
addition,
antimicrobial
antioxidant
properties
this
bioactive
nanoparticle
also
investigated.
excellent
antibacterial
activity
against
one
Gram-negative
pathogens
bacteria,
Escherichia
coli,
Gram-positive
Staphylococcus
aureus,
well
antifungal
Candida
albicans.
obtained
results
indicate
is
significant.
This
can
used
biomedical
pharmacological
fields.
Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(3), P. 381 - 381
Published: March 21, 2023
Biological
particles,
along
with
inorganic
gaseous
and
particulate
pollutants,
constitute
an
ever-present
component
of
the
atmosphere
surfaces.
Among
these
particles
are
fungal
species
colonizing
almost
all
ecosystems,
including
human
body.
Although
inoffensive
to
most
people,
fungi
can
be
responsible
for
several
health
problems,
such
as
allergic
diseases
infections.
Worldwide
disease
incidence
is
increasing,
new
emerging
appearing
yearly.
Reasons
this
increase
expansion
life
expectancy,
number
immunocompromised
patients
(immunosuppressive
treatments
transplantation,
autoimmune
diseases,
immunodeficiency
diseases),
uncontrolled
underlying
conditions
(e.g.,
diabetes
mellitus),
misusage
medication
corticosteroids
broad-spectrum
antibiotics).
Managing
challenging;
only
four
classes
antifungal
drugs
available,
resistance
no
vaccines
have
been
approved.
The
present
work
reviews
implications
in
from
(i.e.,
bronchopulmonary
aspergillosis,
severe
asthma
sensitization,
thunderstorm
asthma,
rhinosinusitis,
occupational
lung
diseases)
infections
superficial,
subcutaneous,
systemic
infections).
Topics
etiological
agent,
risk
factors,
clinical
manifestations,
diagnosis,
treatment
will
revised
improve
knowledge
growing
concern.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: June 21, 2024
Abstract
Background
Dental
pathogens
play
a
crucial
role
in
oral
health
issues,
including
tooth
decay,
gum
disease,
and
infections,
recent
research
suggests
link
between
these
cancer
initiation
progression.
Innovative
therapeutic
approaches
are
needed
due
to
antibiotic
resistance
concerns
treatment
limitations.
Methods
We
synthesized
analyzed
piperine-coated
zinc
oxide
nanoparticles
(ZnO-PIP
NPs)
using
UV
spectroscopy,
SEM,
XRD,
FTIR,
EDAX.
Antioxidant
antimicrobial
effectiveness
were
evaluated
through
DPPH,
ABTS,
MIC
assays,
while
the
anticancer
properties
assessed
on
KB
squamous
carcinoma
cells.
Results
ZnO-PIP
NPs
exhibited
significant
antioxidant
activity
of
50
µg/mL
against
dental
pathogens,
indicating
strong
properties.
Interaction
analysis
revealed
high
binding
affinity
with
pathogens.
showed
dose-dependent
cells,
upregulating
apoptotic
genes
BCL2,
BAX,
P53.
Conclusions
This
approach
offers
multifaceted
solution
combatting
both
infections
cancer,
showcasing
their
potential
for
advancement
healthcare.
It
is
essential
acknowledge
limitations
challenges
associated
use
ZnO
clinical
applications.
These
may
include
regarding
nanoparticle
toxicity,
biocompatibility,
long-term
safety.
Further
rigorous
testing
warranted
address
issues
ensure
safe
effective
translation
into
practice.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 15, 2025
The
polymorphic
microbiome
is
considered
a
new
hallmark
of
cancer.
Advances
in
High-Throughput
Sequencing
have
fostered
rapid
developments
research.
interaction
between
cancer
cells,
immune
and
microbiota
defined
as
the
immuno-oncology
(IOM)
axis.
Fungal
microbes
(the
mycobiome),
although
representing
only
∼
0.1-1%
microbiome,
are
critical
immunologically
active
component
tumor
microbiome.
Accumulating
evidence
suggests
possible
involvement
commensal
pathogenic
fungi
initiation,
progression,
treatment
responsiveness.
tumor-associated
mycobiome
mainly
consists
gut
mycobiome,
oral
intratumoral
mycobiome.
However,
role
remains
poorly
understood,
diversity
complexity
analytical
methods
make
it
challenging
to
access
this
field.
This
review
aims
elucidate
causal
complicit
roles
development
progression
while
highlighting
issues
that
need
be
addressed
executing
such
We
systematically
summarize
advantages
limitations
current
fungal
detection
analysis
methods.
enumerate
integrate
these
recent
findings
into
our
understanding
accompanied
by
prospect
novel
exhilarating
clinical
implications.
Annual Review of Immunology,
Journal Year:
2022,
Volume and Issue:
40(1), P. 121 - 141
Published: Jan. 10, 2022
Invasive
fungal
diseases
are
rare
in
individuals
with
intact
immunity.
This,
together
the
fact
that
there
only
a
few
species
account
for
most
mycotic
diseases,
implies
remarkable
natural
resistance
to
pathogenic
fungi.
Mammalian
immunity
fungi
rests
on
two
pillars,
powerful
immune
mechanisms
and
elevated
temperatures
create
thermal
restriction
zone
species.
Conditions
associated
increased
susceptibility
generally
reflect
major
disturbances
of
function
involving
both
cellular
humoral
innate
adaptive
arms,
which
considerable
redundancy
host
defense
against
In
general,
tissue
invasion
is
controlled
through
either
neutrophil
or
granulomatous
inflammation,
depending
Neutrophils
critical
Candida
spp.
Aspergillus
while
macrophages
essential
controlling
mycoses
due
Cryptococcus
spp.,
Histoplasma
other
The
increasing
number
immunocompromised
patients
climate
change
could
significantly
increase
prevalence
diseases.
Revista Argentina de Microbiología,
Journal Year:
2022,
Volume and Issue:
55(2), P. 189 - 198
Published: Nov. 18, 2022
Candida
albicans
is
a
commensal
of
the
mammalian
microbiome
and
primary
pathogenic
fungus
humans.
It
becomes
severe
health
problem
in
immunocompromised
patients
can
cause
wide
variety
mucosal
systemic
infections.
The
interaction
between
C.
host
cells
characterized
by
expression
virulence
factors
such
as
adhesins
invasins,
secretion
hydrolytic
enzymes,
transition
from
yeast
to
filamentous
hyphae
form,
ability
form
biofilms;
these
features
collectively
result
cell
adhesion,
invasion,
damage.
This
review
describes
complex
interactions
with
cellular
events
that
it
triggers
environment.
We
also
immune
response
induced
antigens
mechanisms
developed
this
avoid
action
antifungal
agents.
es
un
comensal
del
microbioma
de
mamíferos
y
el
principal
hongo
patógeno
humanos.
En
pacientes
inmunocomprometidos
se
convierte
en
grave
problema
salud
por
causar
una
amplia
variedad
infecciones
mucosas
sistémicas.
La
interacción
entre
las
células
huésped
lleva
la
expresión
factores
virulencia,
como
adhesinas
e
invasinas,
secreción
enzimas
hidrolíticas
transición
levadura
hifa
filamentosa,
capaz
para
formar
biopelículas,
lo
que
genera
adherencia,
invasión
daño
celular.
esta
revisión
describimos
compleja
con
célula
los
eventos
celulares
ejecuta
ambiente
patogénico.
También
revisa
respuesta
inmunitaria
inducida
antígenos
mecanismos
desarrollados
este
evitar
acción
agentes
antifúngicos.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 5895 - 5895
Published: May 24, 2022
Vulvovaginal
candidiasis
(VVC)
is
one
of
the
most
common
types
vaginal
infections
in
women
around
world
and
often
underestimated
by
both
patients
doctors.
Research
on
pathogenesis
fungal
over
last
20
years
has
resulted
a
closer
understanding
virulence
factors
involved
Candida
epithelial
invasion
their
mechanisms
action.
Recently,
attention
was
drawn
to
enormous
complexity
interaction
between
yeast-like
fungi
host
cells,
as
well
level
host’s
response
infection
impact
course
treatment
VVC.
Our
work
provides
broad
description
already
known
some
new
reports
(such
phenotypic
switching
or
biofilm
formation
capacity)
importance
for
tissue
At
same
time,
we
also
focus
interactions
with
cells
local
innate
immune
that
are
now
considered
equally
important
this
case.
The
presented
review
describes
aspects
still
unknown
pathogenicity
associated
infections.
Virulence,
Journal Year:
2022,
Volume and Issue:
13(1), P. 1573 - 1589
Published: Sept. 18, 2022
Antifungal
resistance
to
Candida
pathogens
increases
morbidity
and
mortality
of
immunosuppressive
patients,
an
emerging
crisis
worldwide.
Understanding
the
prevalence
antifungal
susceptibility
pattern
is
necessary
control
treat
candidiasis.
We
aimed
systematically
analyse
profiles
species
published
in
last
ten
years
(December
2011
December
2021)
from
mainland
China.
The
studies
were
collected
PubMed,
Google
Scholar,
Science
Direct
search
engines.
Out
89
included
studies,
a
total
44,716
isolates
collected,
mainly
comprising
C.
albicans
(49.36%),
tropicalis
(21.89%),
parapsilosis
(13.92%),
glabrata
(11.37%).
lowest
was
detected
for
azole
group;
fluconazole
susceptibilities
against
parapsilosis,
albicans,
glabrata,
tropicalis,
guilliermondii,
pelliculosa,
auris
93.25%,
91.6%,
79.4%,
77.95%,
76%,
50%,
0%
respectively.
Amphotericin
B
anidulafungin
most
susceptible
drugs
all
species.
Resistance
linked
with
mutations
ERG11,
ERG3,
ERG4,
MRR1-2,
MSH-2,
PDR-1
genes.
Mutation
FKS-1
FKS-2
causing
echinocandins
stated
two
studies.
Gaps
studies'
characteristics
detected,
such
as
79.77%,
47.19
%,
26.97%,
7.86%,
4.49%
did
not
mention
rates,
age,
gender,
breakpoint
reference
guidelines,
fungal
identification
method,
current
study
demonstrates
overall
species,
gaps
surveillance
risk-reduction
strategies
that
could
be
supportive
candidiasis
therapy
researchers
their
future