Comprehensive pharmacokinetic profiling and molecular docking analysis of natural bioactive compounds targeting oncogenic biomarkers in breast cancer DOI Creative Commons

Basim Othman,

Saba Beigh,

Mohammad Albanghali

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 13, 2025

Breast cancer is one of the leading causes death in women worldwide, highlighting crucial need for novel and effective treatments. In this study, we look at ability four natural compounds i.e. Berberine, Curcumin, Withaferin A, Ellagic Acid to target important breast biomarkers such as B-cell lymphoma 2 (BCL-2), programmed death-ligand 1 (PDL-1), cyclin-dependent kinase 4/6 (CDK4/6) fibroblast growth factor receptor (FGFR). These indicators have roles tumor development, survival, immune response, cell cycle control, making them potential targets future Our study employs a variety techniques, including pharmacokinetic profiling (ADME), molecular docking, dynamics simulations, determine how successful these drugs could be therapy. The investigation found that Berberine stand out due their high absorption solubility, implying they suitable clinical application. When ran docking discovered substantial connections between chemicals proteins. Additionally, has binding affinity - 9.3 kcal/mol BCL-2, indicating it can impair protein's cell-protective activities. Acid, on other hand, an even higher PDL-1 9.8 kcal/mol, showing may able increase responses against tumors. Molecular simulations over 100 ns demonstrated stability protein-ligand complexes. Interestingly, was more structurally stable than throughout simulations. We consistent interactions key residues For example, (CID: 5281855) established persistent linkages with LYS43, ASP163, VAL27, whereas 2353) interacted ALA41, LEU152 simulation. conclusion, combination good pharmacokinetics, robust biomarkers, complexes makes interesting candidates further inhibitors treatment. findings establish framework research into inventive techniques effectively combating cancer.

Language: Английский

Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review DOI Creative Commons
Jyoti Singh,

Hamita Preet Kaur,

Anjali Verma

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(39), P. 35452 - 35469

Published: Sept. 19, 2023

Pomegranate peel, derived from the processing of Punica granatum L. (pomegranate), has traditionally been considered agricultural waste. However, recent studies have revealed its potential as a rich source bioactive compounds with diverse pharmacological effects. peel is reservoir antioxidants, polyphenols, dietary fiber, and vitamins, which contribute to remarkable bioactivity. Studies demonstrated anti-inflammatory, cardioprotective, wound healing, anticancer, antimicrobial properties pomegranate owing presence phytochemicals, such gallic acid, ellagic punicalagin. The extraction requires careful selection techniques maximize yield quality. Green methods, including pressurized liquid (PLE), ultrasound-assisted (UAE), microwave-assisted (MAE), enzyme-assisted (EAE), offer efficient sustainable alternatives traditional methods. Furthermore, utilized in food industry, where it can significantly enhance nutritional value, organoleptic characteristics, shelf life products. be used develop innovative functional foods, nutraceuticals, other value-added products, providing new opportunities for pharmaceutical, cosmetic, industries.

Language: Английский

Citations

50
Extraction of phenolic compounds from grape pomace using ohmic heating: Chemical composition, bioactivity and bioaccessibility DOI Creative Commons
Pedro Ferreira-Santos, Clarisse Nobre, Rui M. Rodrigues

et al.

Food Chemistry, Journal Year: 2023, Volume and Issue: 436, P. 137780 - 137780

Published: Oct. 16, 2023

This study addresses the effectiveness of ohmic heating technology (OH) for sustainable recovery phenolic compounds from Grape Pomace (GP) by hydroethanolic extraction. GP extracts biological potential was evaluated in terms antioxidant activity, cytotoxicity and preventive effect against reactive oxygen species (ROS). To understand if can be used as a functional ingredient, simulated gastrointestinal digestion performed to evaluate bioaccessibility. OH-assisted extraction proved an effective process with high capacity. The increased concentration total phenolics biotransformation high-molecular (anthocyanins, flavonoids resveratrol) simpler acids, improving extract displayed selective action cancer cells (Caco-2 HeLa) promoted ROS prevention. results highlighted ability OH bioactives its application nutraceutical or food formulations.

Language: Английский

Citations

48
Seaweed-derived phenolic compounds as diverse bioactive molecules: A review on identification, application, extraction and purification strategies DOI
Abbas Sadeghi, Ali Rajabiyan,

Nafise Nabizade

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131147 - 131147

Published: March 26, 2024

Language: Английский

Citations

32
Trends and challenges of fruit by-products utilization: insights into safety, sensory, and benefits of the use for the development of innovative healthy food: a review DOI Creative Commons
Md. Mehedi Hasan, Md. Rakibul Islam,

Ahmed Redwan Haque

et al.

Bioresources and Bioprocessing, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 18, 2024

Abstract A significant portion of the human diet is comprised fruits, which are consumed globally either raw or after being processed. huge amount waste and by-products such as skins, seeds, cores, rags, rinds, pomace, etc. generated in our homes agro-processing industries every day. According to previous statistics, nearly half fruits lost discarded during entire processing chain. The concern arises when those wastes damage environment simultaneously cause economic losses. There a lot potential these for reuse variety applications, including isolation valuable bioactive ingredients their application developing healthy functional foods. development novel techniques transformation materials into marketable commodities may offer workable solution this issue while also promoting sustainable growth from bio-economic viewpoint. This approach can manage well add value enterprises. goal study twofold based on scenario. first present brief overview most substances found by-products. second review current status valorization trends techniques, safety assessments, sensory attributes, challenges. Moreover, specific attention drawn future perspective, some solutions discussed report.

Language: Английский

Citations

26
A conceptual review on classification, extraction, bioactive potential and role of phytochemicals in human health DOI Creative Commons

Prashant Anil Pawase,

Chetna Goswami,

Rafeeya Shams

et al.

Future Foods, Journal Year: 2024, Volume and Issue: 9, P. 100313 - 100313

Published: Feb. 9, 2024

Natural substances present in plants called phytochemicals are essential for fostering favourable human health outcomes. These bioactive compounds support general via a variety of processes. Phytochemicals have strong antioxidant qualities that aid scavenging dangerous free radicals from the body. This activity can promote cellular by lowering oxidative stress, major contributor to ageing and onset chronic diseases. exhibit dosage-dependent effect, which either beneficial or detrimental outcome. Several vivo vitro studies been conducted strongly supports health-promoting properties diets. A diet is rich derived fruits, vegetables, nuts, legumes, whole grains has linked lower incidence lipid peroxidation, cardiovascular disorders, cancer, other illnesses. Compounds such as β-glucans echinacea stimulate immune responses, enhancing body's ability defend against infections The study expanded understanding biochemical diversity their potential applications various fields life, including food nutrition, pharmaceuticals, cosmetics, agriculture. review deals with significance varieties used enhance nutrition overall health.

Language: Английский

Citations

26
Chitosan, Poly(vinyl alcohol) and Chitosan/Poly(vinyl alcohol) based active films loaded with white turmeric powder for food packaging applications DOI
Veena G. Bhat, Saraswati P. Masti, Shivayogi S. Narasagoudr

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104402 - 104402

Published: May 24, 2024

Language: Английский

Citations

19
Phytochemicals: a new arsenal in drug discovery DOI Open Access

Manal Hatem Ahmed,

Saja Ismail Karkush,

Sumeia Abbas Ali

et al.

International Journal of Medical Science and Dental Health, Journal Year: 2024, Volume and Issue: 10(01), P. 29 - 44

Published: Jan. 1, 2024

In ancient times traditional herbs were used to treat different diseases such as stomach discomfort, toothache, body pain and inflammation, diarrhea, malaria, typhoid, diabetes, so on. Medicinally important plants are recognized have chemicals or phytochemicals that could be useful for illness treatment medication manufacture. These compounds occur naturally in plant parts (leaves, stems, barks, roots) referred secondary metabolites because, like primary metabolites, they synthesized protect the rather than growth. Fortunately humans, majority of these therapeutic properties against a variety health problems. Resistance antibiotics is one world's most critical challenges, with numerous infections rapidly gaining resistance conventional antimicrobials. There currently no viable agent ability reverse antimicrobial resistance, several leading laboratories working hard find new Plant-based chemical received comparatively little attention context development. Natural piqued interest drug development scientists because their structural diversity, novelty, abundance, bioactivity. Cancer major problem. Despite interventions available, huge number patients die each year result cancer disorders. The rising research direction healthcare pharmacy an effective side-effect-free anticancer medication. Chemical entities found proven particularly promising this area. Bioactive preferred act differentially on cells while leaving normal alone. This review provides overview utility medicinal well sources, discovery process, efficacy safety phytochemicals, current applications, developments screening technologies, future directions.

Language: Английский

Citations

17
The Impact of Curcumin, Resveratrol, and Cinnamon on Modulating Oxidative Stress and Antioxidant Activity in Type 2 Diabetes: Moving beyond an Anti-Hyperglycaemic Evaluation DOI Creative Commons
Michalina Banaszak, Ilona Górna, Dagmara Woźniak

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 510 - 510

Published: April 24, 2024

Research indicates that up to half of the population resorts dietary supplements for managing diseases such as type 2 diabetes rather than changing their nutritional habits. These not only aim have an anti-hyperglycaemic effect but also seek reduce oxidative stress prevent complications. This systematic literature review aims evaluate efficacy curcumin, resveratrol, and cinnamon in modulating antioxidant activity individuals with diabetes. Data were collected from PubMed, Web Sciences, Scopus databases regarding impact on total capacity (TAC), malondialdehyde (MDA), tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) levels this review. Effect sizes each study calculated using Cohen’s or Hedges’s d coefficient. Parameters inflammatory status, TAC, MDA, TNF-α, IL-6, hs-CRP, improved following phytochemicals. Additionally, exhibited regulatory effects carbohydrate metabolism by reducing glucose, insulin, glycated haemoglobin concentrations lipid lowering cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG) increasing high-density (HDL). Incorporating into diets may be beneficial maintaining organism homeostasis improving metabolic control However, conflicting results reported highlight need further detailed investigations effectiveness phytochemical use

Language: Английский

Citations

17
Recent Advances in Conventional and Innovative Extraction Techniques for Recovery of High-Added Value Compounds for Food Additives and Nutraceuticals DOI Creative Commons

Abhishek Bisht,

Snehalata Sahu, Anand Kumar

et al.

Food Physics, Journal Year: 2025, Volume and Issue: unknown, P. 100047 - 100047

Published: Jan. 1, 2025

Language: Английский

Citations

2
Recent applications of microencapsulation techniques for delivery of functional ingredient in food products: A comprehensive review DOI Creative Commons

Dwip Das Emon,

Md. S. Islam, Md. Anisur Rahman Mazumder

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100923 - 100923

Published: Feb. 12, 2025

Language: Английский

Citations

2