Horticulturae,
Journal Year:
2023,
Volume and Issue:
9(7), P. 737 - 737
Published: June 23, 2023
Polygala
fallax
Hemsl.,
a
species
belonging
to
the
genus
and
family
Polygalaceae,
is
primarily
distributed
in
southern
China.
Wild
P.
Hemsl.
(Polygalaceae)
currently
endangered,
but
its
utilization
value
has
not
yet
been
thoroughly
investigated.
The
present
review
summarizes
morphological
structural
characteristics,
wild
resource
distribution,
chemical
constituents
pharmacological
efficacy,
artificial
breeding
cultivation
techniques,
of
facilitate
future
studies
on
conservation
use
Hemsl
plants.
We
conclude
that
(i)
medicinal
edible
plant,
also
eco-economic
ornamental
value;
(ii)
roots
are
primary
parts,
which
contain
pharmacologically
active
compounds
such
as
saponins,
flavones,
oligosaccharide
polyesters,
polysaccharides,
sterols,
organic
acids,
etc.;
(iii)
shows
various
efficacies
including
anti-inflammatory
effects,
antivirus
antioxidative
an
immunity-boosting
function,
hepatic-protective
hypolipidemic
effect,
blood-activating,
stasis-eliminating
antitumor,
etc.
More
research
applications
needed,
especially
efforts
identify
effective
constituents,
quality
control,
clinical
applications.
resources
should
be
enhanced,
aboveground
efficacy
other
flavones
further
explored.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 2, 2024
Abstract
Cancer
remains
a
significant
global
public
health
concern,
with
increasing
incidence
and
mortality
rates
worldwide.
Oxidative
stress,
characterized
by
the
production
of
reactive
oxygen
species
(ROS)
within
cells,
plays
critical
role
in
development
cancer
affecting
genomic
stability
signaling
pathways
cellular
microenvironment.
Elevated
levels
ROS
disrupt
homeostasis
contribute
to
loss
normal
functions,
which
are
associated
initiation
progression
various
types
cancer.
In
this
review,
we
have
focused
on
elucidating
downstream
that
influenced
oxidative
stress
carcinogenesis.
These
include
p53,
Keap1-NRF2,
RB1,
p21,
APC,
tumor
suppressor
genes,
cell
type
transitions.
Dysregulation
these
can
lead
uncontrolled
growth,
impaired
DNA
repair
mechanisms,
evasion
death,
all
hallmark
features
development.
Therapeutic
strategies
aimed
at
targeting
emerged
as
area
investigation
for
molecular
biologists.
The
objective
is
limit
response
time
cancer,
including
liver,
breast,
prostate,
ovarian,
lung
cancers.
By
modulating
redox
balance
restoring
homeostasis,
it
may
be
possible
mitigate
damaging
effects
enhance
efficacy
treatments.
targeted
therapies
interventions
specifically
address
impact
holds
great
promise
improving
patient
outcomes.
approaches
antioxidant-based
treatments,
redox-modulating
agents,
restore
function
affected
stress.
summary,
understanding
carcinogenesis
process
through
therapeutic
utmost
importance
combating
Further
research
needed
unravel
complex
mechanisms
underlying
stress-related
develop
effective
translated
into
clinical
applications
management
treatment
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(4), P. 989 - 989
Published: Feb. 16, 2023
The
açaí
palm
(Euterpe
oleracea
Mart.),
a
species
belonging
to
the
Arecaceae
family,
has
been
cultivated
for
thousands
of
years
in
tropical
Central
and
South
America
as
multipurpose
dietary
plant.
recent
introduction
fruit
its
nutritional
healing
qualities
regions
outside
origin
rapidly
expanded
global
demand
berry.
health-promoting
disease-preventing
properties
this
plant
are
attributed
numerous
bioactive
phenolic
compounds
present
leaf,
pulp,
fruit,
skin,
seeds.
purpose
review
is
an
up-to-date,
comprehensive,
critical
evaluation
health
benefits
phytochemicals
with
special
focus
on
cellular
molecular
mechanisms
action.
In
vitro
vivo
studies
showed
that
possesses
antioxidant
anti-inflammatory
exerts
cardioprotective,
gastroprotective,
hepatoprotective,
neuroprotective,
renoprotective,
antilipidemic,
antidiabetic,
antineoplastic
activities.
Moreover,
clinical
trials
have
suggested
can
protect
against
metabolic
stress
induced
by
oxidation,
inflammation,
vascular
abnormalities,
physical
exertion.
Due
medicinal
absence
undesirable
effects,
shows
promising
future
promotion
disease
prevention,
addition
vast
economic
potential
food
cosmetic
industries.
Brain Behavior and Immunity,
Journal Year:
2024,
Volume and Issue:
119, P. 494 - 506
Published: April 22, 2024
Alcohol
Use
Disorder
(AUD)
is
a
persistent
condition
linked
to
neuroinflammation,
neuronal
oxidative
stress,
and
neurodegenerative
processes.
While
the
inhibition
of
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
has
demonstrated
effectiveness
in
reducing
liver
inflammation
associated
with
alcohol,
its
impact
on
brain
remains
largely
unexplored.
This
study
aimed
assess
effects
alirocumab,
monoclonal
antibody
targeting
PCSK9
lower
systemic
low-density
lipoprotein
cholesterol
(LDL-C),
central
nervous
system
(CNS)
pathology
rat
model
chronic
alcohol
exposure.
Alirocumab
(50
mg/kg)
or
vehicle
was
administered
weekly
for
six
weeks
32
male
rats
subjected
35
%
ethanol
liquid
diet
control
(n
=
8
per
group).
The
evaluated
expression,
LDL
receptor
(LDLR)
neuroinflammatory
markers
tissues.
Chronic
exposure
increased
expression
brain,
while
alirocumab
treatment
significantly
upregulated
LDLR
reduced
stress
neurons
vasculature
(3-NT,
p22phox).
also
mitigated
ethanol-induced
microglia
recruitment
cortex
hippocampus
(Iba1).
Additionally,
decreased
pro-inflammatory
cytokines
chemokines
(TNF,
CCL2,
CXCL3)
whole
tissue
attenuated
upregulation
adhesion
molecules
(ICAM1,
VCAM1,
eSelectin).
presents
novel
evidence
that
diminishes
modifies
neuroimmune
interactions
elicited
by
Further
investigation
needed
elucidate
mechanisms
which
signaling
influences
context
Redox Biology,
Journal Year:
2024,
Volume and Issue:
76, P. 103311 - 103311
Published: Aug. 14, 2024
Clinical
studies
have
previously
established
the
role
of
olive
products
in
cardiovascular
disease
(CVD)
prevention,
whilst
identification
responsible
constituents
for
beneficial
effects
is
still
pending.
We
sought
to
assess
and
compare
cardioprotective
potential
oleuropein
(OL),
hydroxytyrosol
(HT),
oleocanthal
(OC)
oleanolic
Acid
(OA),
regarding
Ischemia/Reperfusion
Injury
(IRI)
CVD
risk
factors
alleviation.
The
scope
study
was
design
a
potent
safe
combinatorial
therapy
high-cardiovascular-risk
patients
on
bench-to-bedside
approach.
evaluated
IRI-limiting
6-weeks
treatment
with
OL,
HT,
OC
or
OA
at
nutritional
doses,
healthy
metabolic
syndrome
(MS)-burdened
mice.
Three
regimens
were
designed
mixture
preponderant
benefits
(OL-HT-OC,
Combo
2),
including
infarct
sparing
antiglycemic
potency,
compared
isolated
compounds,
further
investigated
its
anti-atherosclerotic
effects.
In
vivo
experiments
revealed
that
combination
regimen
2
presented
most
favorable
limiting
size
hyperglycemia,
which
selected
be
clinical
setting
Chronic
Coronary
Artery
Syndrome
(CCAS)
patients.
Cardiac
function,
inflammation
markers
oxidative
stress
assessed
baseline
after
4
weeks
OL-HT-OC
supplement
study.
found
significantly
reduced
Controls.
OL
exhibited
antihyperglycemic
properties
attenuated
hypercholesterolemia.
OL-HT-OA,
OL-HT-OC-OA
cardioprotective,
whereas
only
mitigated
hyperglycemia.
cardioprotection
attributed
apoptosis
suppression,
enhanced
antioxidant
upregulation
enzymes.
Additionally,
it
atherosclerotic
plaque
extent
vivo.
ameliorated
cardiac,
vascular
endothelial
function
small-scale
Conclusively,
exerts
vivo,
remarkable
clinically
translatable
high-risk
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 820 - 820
Published: July 8, 2024
Dietary
restriction
(DR)
protocols
frequently
employ
intermittent
fasting.
Following
a
period
of
fasting,
meal
consumption
increases
lipogenic
gene
expression,
including
that
NADPH-generating
enzymes
fuel
lipogenesis
in
white
adipose
tissue
(WAT)
through
the
induction
transcriptional
regulators
SREBP-1c
and
CHREBP.
knockout
mice,
unlike
controls,
did
not
show
an
extended
lifespan
on
DR
diet.
WAT
cytoplasmic
NADPH
is
generated
by
both
malic
enzyme
1
(ME1)
pentose
phosphate
pathway
(PPP),
while
liver
primarily
synthesized
folate
cycle
provided
one-carbon
units
serine
catabolism.
During
daily
fasting
diet,
fatty
acids
are
released
from
transported
to
peripheral
tissues,
where
they
used
for
beta-oxidation
phospholipid
lipid
droplet
synthesis,
monounsaturated
(MUFAs)
may
activate
Nrf1
inhibit
ferroptosis
promote
longevity.
Decreased
PPP
stimulated
browning
protected
high-fat
high
levels
macrophages
linked
obesity.
But
oscillations
[NADPH]/[NADP+]
feeding
cycles
play
important
role
maintaining
metabolic
plasticity
drive
Studies
measuring
malate/pyruvate
as
proxy
[NADPH]/[NADP+],
well
studies
using
fluorescent
biosensors
expressed
animal
models
monitor
changes
needed
during
ad
libitum
diets
determine
associated
with
