Nanotechnology Advances in the Detection and Treatment of Cancer: An Overview

Nanotheranostics, Journal Year: 2022, Volume and Issue: 6(4), P. 400 - 423

Published: Jan. 1, 2022

Over the last few years, progress has been made across nanomedicine landscape, in particular, invention of contemporary nanostructures for cancer diagnosis and overcoming complexities clinical treatment cancerous tissues.Thanks to their small diameter large surface-to-volume proportions, nanomaterials have special physicochemical properties that empower them bind, absorb transport high-efficiency substances, such as molecular drugs, DNA, proteins, RNAs, probes.They also excellent durability, high carrier potential, ability integrate both hydrophobic hydrophilic compounds, compatibility with various routes, making especially appealing over a wide range oncology fields.This is due configurable scale, structure, surface properties.This review paper discusses how can function therapeutic vectors enhance value molecules; be used medicinal products gene therapy, photodynamics, thermal treatment; finally, application form imaging agents diagnose map tumor growth.

Language: Английский

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Gold nanoparticles in microelectronics advancements and biomedical applications

Materials Science and Engineering B, Journal Year: 2024, Volume and Issue: 301, P. 117191 - 117191

Published: Jan. 13, 2024

Language: Английский

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Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104357 - 104357

Published: March 12, 2023

Language: Английский

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A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3482 - 3482

Published: July 25, 2024

Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,

Language: Английский

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Tumor microenvironment responsive nanozymes for multimodal imaging of tumors

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100032 - 100032

Published: Jan. 29, 2024

Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.

Language: Английский

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Recent progress and applications of gold nanotechnology in medical biophysics using artificial intelligence and mathematical modeling

Nano Express, Journal Year: 2021, Volume and Issue: 2(2), P. 022001 - 022001

Published: Jan. 20, 2021

Abstract In this topical review, we will explore and challenge how artificial intelligence (AI) mathematical modeling apply towards the future in medical applications, focusing on their interactions with gold nanotechnology. There have been rapid advancements applications of AI biophysics. These specific techniques help to improve studies related nanoscale technology. Many works published relation topic; it is now time collectively analyze review them assess contributions these made within Through both theoretical clinical data examined for a fresh present-day understanding. Observations set parameters defined equations through are give explanation variable interaction. This focuses nanoparticle synthesis preparation via Turkevich Brust Schiffrins one-pot method. From this, findings show that size, shape, overall functionality affect its synthetic properties. Depending characteristics nanoparticle, ability maximize light absorbency, wavelengths, optical densities particle limited. Finding an ideal wavelength (dependent sizing) allows higher absorbency itself. Examining cellular uptake cytotoxicity done so transmission electron microscope (TEM) Fourier transform infrared radiation (FT-IR) spectroscopy. By manipulating stochastic diagnostic models, efficiency precision cancer therapy ensure maximal treatment. Set conditions allow tumor treatment planning, where manipulated nano-probes used nanoparticle-based therapy. Versatility sensors multimodal imaging assistance further therapeutic practices. Drawn conclusions expand knowledge growth technology research biophysics application using modeling.

Language: Английский

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Recent advances in waste-recycled nanomaterials for biomedical applications: Waste-to-wealth

Nanotechnology Reviews, Journal Year: 2021, Volume and Issue: 10(1), P. 1662 - 1739

Published: Jan. 1, 2021

Abstract Global overpopulation, industrial expansion, and urbanization have generated massive amounts of wastes. This is considered as a significant worldwide challenge that requires an urgent solution. Additionally, remarkable advances in the field biomedicine impacted entire spectrum healthcare medicine. has paved way for further refining outcomes biomedical strategies toward early detection treatment different diseases. Various nanomaterials (NMs) been dedicated to applications including drug delivery, vaccinations, imaging modalities, biosensors. However, toxicity still main factor restricting their use. NMs recycled from types wastes present pioneering approach not only avoid hazardous effects on environment, but also implement circular economy practices, which are crucial attain sustainable growth. Moreover, utilized safe, yet revolutionary alternative with outstanding potential many applications. review focuses waste NMs, synthesis, properties, multiple special emphasis role control Their pivotal therapeutic actions antimicrobial, anticancer, antioxidant nanodrugs, vaccines will be outlined. The ongoing advancements design expanding diagnostic roles diverse era precision

Language: Английский

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Copper‐based nanomaterials for cancer theranostics

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 14(4)

Published: April 13, 2022

Abstract Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one most widely studied materials in cancer treatment. In recent years, great progress has been made field biomedicine, especially treatment diagnosis tumors. This review begins classification synthetic strategies NMs. Then, according to abundant special NMs, their application biomedicine is summarized detail. For imaging, such as photoacoustic positron emission tomography multimodal imaging based on summarized, well improve diagnostic effectiveness. Moreover, a series structures functions underlying property activity relationship were shown highlight promising therapeutic performance. used monotherapies, photothermal therapy (PTT) chemodynamic (CDT). sophisticated design composition, structure, surface fabrication can endow these more modalities therapy. To further efficiency treatment, combined was introduced Finally, challenges, critical factors, future prospects for clinical translation multifunctional theranostic agents also considered discussed. The aim this provide better understanding key consideration rational increasingly important new paradigm agents. article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools Vivo Nanodiagnostics Imaging

Language: Английский

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Formulation of Quaternized Aminated Chitosan Nanoparticles for Efficient Encapsulation and Slow Release of Curcumin

Molecules, Journal Year: 2021, Volume and Issue: 26(2), P. 449 - 449

Published: Jan. 16, 2021

An effective drug nanocarrier was developed on the basis of a quaternized aminated chitosan (Q-AmCs) derivative for efficient encapsulation and slow release curcumin (Cur)-drug. A simple ionic gelation method conducted to formulate Q-AmCs nanoparticles (NPs), using different ratios sodium tripolyphosphate (TPP) as an crosslinker. Various characterization tools were employed investigate structure, surface morphology, thermal properties formulated nanoparticles. The NPs displayed smaller particle size 162 ± 9.10 nm, higher positive charges, with maximum potential +48.3 mV, compared native (AmCs) (231 7.14 +32.8 mV). Cur-drug efficiency greatly improved reached value 94.4 0.91%, 75.0 1.13% AmCs NPs. Moreover, in vitro Cur-release profile investigated under conditions simulated gastric fluid [SGF; pH 1.2] colon [SCF; 7.4]. For NPs, rate meaningfully decreased, recorded cumulative 54.0% at 7.4, 73.0% exhibited acceptable biocompatibility biodegradability. These findings emphasize that have outstanding delivery anticancer drugs.

Language: Английский

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Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(1), P. 169 - 169

Published: Jan. 4, 2022

Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the world, despite considerable advances in therapy. The formation colorectal adenomas and invasive adenocarcinomas consequence succession genetic epigenetic changes normal colonic epithelium. Genetic processes associated with onset, development, metastasis sporadic CRC have been studied depth, resulting identifying biomarkers might be used to predict behaviour prognosis beyond staging influence therapeutic options. A novel biomarker, or group biomarkers, must discovered order build an accurate clinically useful test may as alternative conventional methods for early detection identify prospective new intervention targets. To minimise mortality burden cancer, screening higher accuracy nano-based diagnostic precision are needed. Cytotoxic medication has negative side effects restricted by resistance. One most promising treatment techniques use carrier system delivery mechanism. deliver cytotoxic medicines, targeted nanoparticles take advantage differently expressed molecules on surface cells. different compounds ligands interact cells, enabling efficient antitumor medicines. Formulations based aid diagnosis help overcome limitations traditional treatments, including low water solubility, nonspecific biodistribution, bioavailability. This article addresses about molecular pathogenesis highlights biomarkers. It also provides conceptual knowledge nanotechnology-based approaches malignant cancer.

Language: Английский

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