The Influence of Dietary Interventions on Arterial Stiffness in Overweight and Obese Subjects

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1440 - 1440

Published: March 16, 2023

Arterial stiffness is often increased in overweight/obese subjects before the development of hypertension. It also one earliest indicators cardiovascular disease risk and can be considered a good predictor subclinical dysfunction. significant prognostic factor influencing risk, which dietary habits modify. Obese patients should use caloric-restricted diet because it augments aortic distensibility, diminishes pulse wave velocity (PWV), increases activity endothelial nitric oxide synthases. High intake saturated fatty acids (SFA), trans fats, cholesterol, typical for Western diet, impairs function raises brachial-ankle PWV. The replacement SFA with monounsaturated (MUFA) or polyunsaturated (PUFA) derived from seafood plants arterial stiffness. dairy product (excluding butter) decreases PWV general population. high-sucrose causes toxic hyperglycemia Complex carbohydrates low glycemic index (including isomaltose) recommended to keep vascular health. high sodium (>10 g/day), particularly associated potassium consumption, has deleterious effect on (↑ baPWV). Since vegetables fruits are sources vitamins phytochemicals, they Thus, recommendation prevent similar Mediterranean rich products, plant oils, fish, minimal red meat five servings daily.

Language: Английский

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Management of Metabolic-Associated Fatty Liver Disease/Metabolic Dysfunction-Associated Steatotic Liver Disease: From Medication Therapy to Nutritional Interventions

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2220 - 2220

Published: July 11, 2024

Non-alcoholic fatty liver disease (NAFLD) is a common long-lasting that affects millions of people around the world. It best identified with hepatic fat build-up ultimately leads to inflammation and damage. The classification nomenclature NAFLD have long been controversial topic, until 2020 when group international experts recommended substituting MAFLD (metabolic dysfunction-associated FLD). was then terminologically complemented in 2023 by altering it MASLD, i.e., metabolic steatotic (MASLD). Both MASLD terminologies comprise element disorder, as they offer diagnostic benchmarks are embedded risk factors underlie disease. (as multisystemic disease) provides comprehensive definition includes larger population patients who at morbidity mortality, well adverse cardiovascular diabetes outcomes. highlights risks lean or normal weight individuals, factor has not accentuated discussed previous guidelines. Novel antihyperglycemic agents, anti-hyperlipidemic drugs, lifestyle modifications, nutritional interventions, exercise therapies extensively studied MASLD. Nutrition plays vital role managing both conditions, where centralizing on diet rich whole vegetables, fruits, foods, healthy fats, proteins, specific nutrients (e.g., omega-3 acids fibers) can improve insulin resistance reduce inflammation. Thus, essential understand nutrition these conditions work develop an individualized plan for optimal health. This review discusses prevention strategies NAFLD/MAFLD/MASLD management, particular attention correction.

Language: Английский

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The Effects of Antioxidant Supplementation on the Pathologic Mechanisms of Metabolic Syndrome and Cardiovascular Disease Development

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1641 - 1641

Published: May 27, 2024

In people with obesity, diabetes, and hypertension, lipid glucose metabolism oxidative stress generation interact. This condition, known as a “metabolic syndrome” (MetS), presents global challenge appears to be the underlying mechanism for development of cardiovascular diseases (CVDs). review is designed based on evidence indicating pathogenic mechanisms MetS. detail, we will look at induction in MetS, effects elevated levels condition’s pathophysiology, matters related endothelial function. According different components MetS pathophysiological network, antioxidants dysfunction are reviewed. After considering strategic role pathophysiology its associated CVDs, management by antioxidant supplementation seems an appropriate therapeutic approach.

Language: Английский

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Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?

Pharmacological Research, Journal Year: 2024, Volume and Issue: 200, P. 107058 - 107058

Published: Jan. 11, 2024

Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide. While many factors can contribute to CVD, atherosclerosis is cardinal underlying pathology, its development associated with several metabolic risk including dyslipidemia obesity. Recent studies have definitively demonstrated a link between low-grade systemic inflammation two relevant abnormalities: hypercholesterolemia Interestingly, both disorders are also endothelial dysfunction/activation, proinflammatory prothrombotic phenotype endothelium that involves leukocyte infiltration into arterial wall, one earliest stages atherogenesis. This article reviews current literature on intricate relationship obesity dysfunction, discusses effectiveness present, emerging in-development pharmacological therapies used treat these focus their effects inflammatory state cardiovascular risk.

Language: Английский

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Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

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Theabrownin as a Potential Prebiotic Compound Regulates Lipid Metabolism via the Gut Microbiota, Microbiota-Derived Metabolites, and Hepatic FoxO/PPAR Signaling Pathways

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(15), P. 8506 - 8520

Published: April 3, 2024

The dysregulation of lipid metabolism poses a significant health threat, necessitating immediate dietary intervention. Our previous research unveiled the prebiotic-like properties theabrownin. This study aimed to further investigate theabrownin-gut microbiota interactions and their downstream effects on using integrated physiological, genomic, metabolomic, transcriptomic approaches. results demonstrated that theabrownin significantly ameliorated dyslipidemia, hepatic steatosis, systemic inflammation induced by high-fat/high-cholesterol diet (HFD). Moreover, improved HFD-induced gut dysbiosis alterations in microbiota-derived metabolites. Additionally, detailed interplay between was revealed. Analysis transcriptome indicated FoxO PPAR signaling pathways played pivotal roles response interactions, primarily through upregulating

Language: Английский

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Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2631 - 2631

Published: June 5, 2023

Natural herbs and functional foods contain bioactive molecules capable of augmenting the immune system mediating anti-viral functions. Functional foods, such as prebiotics, probiotics, dietary fibers, have been shown to positive effects on gut microbiota diversity function. The use has linked enhanced immunity, regeneration, improved cognitive function, maintenance microbiota, significant improvement in overall health. plays a critical role maintaining health disruptions its balance various problems. SARS-CoV-2 infection affect diversity, emergence variants poses new challenges combat virus. recognizes infects human cells through ACE2 receptors prevalent lung epithelial cells. Humans are prone because their respiratory gastrointestinal tracts rich microbial high levels TMPRSS2. This review article explores potential mitigating impact strategy these effects.

Language: Английский

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The Influence of Antioxidants on Oxidative Stress-Induced Vascular Aging in Obesity

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1295 - 1295

Published: June 17, 2023

Obesity is a worldwide trend that growing in incidence very fast. Adipose tissue dysfunction caused by obesity associated with the generation of oxidative stress. Obesity-induced stress and inflammation play key role pathogenesis vascular diseases. Vascular aging one main mechanisms. The aim this study to review effect antioxidants on obesity. In order achieve aim, paper designed obesity-caused adipose remodeling, generated high levels stress, effects obesity, redox balance, aging. It seems diseases obese individuals are complex networks pathological develop proper therapeutic tool, first, there need for better understanding interactions between Based these interactions, suggests different lines strategies include change lifestyle prevent control remodelling, oxidant-antioxidant suppression, against Some support strategies, making them appropriate conditions such as stress-induced individuals.

Language: Английский

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The Preventive Mechanisms of Bioactive Food Compounds against Obesity-Induced Inflammation

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1232 - 1232

Published: June 7, 2023

Dietary patterns are promising strategies for preventing and treating obesity its coexisting inflammatory processes. Bioactive food compounds have received considerable attention due to their actions against obesity-induced inflammation, with limited harmful side effects. They perceived as ingredients or dietary supplements other than those necessary meet basic human nutritional needs responsible positive changes in the state of health. These include polyphenols, unsaturated fatty acids, probiotics. Although exact mechanisms bioactive compounds’ action still poorly understood, studies indicated that they involve modulation secretion proinflammatory cytokines, adipokines, hormones; regulate gene expression adipose tissue; modify signaling pathways response. Targeting consumption and/or supplementation foods anti-inflammatory potential may represent a new approach inflammation treatment. Nevertheless, more needed evaluate compound intake, especially times doses. Moreover, worldwide education about advantages is warranted limit consequences unhealthy patterns. This work presents review synthesis recent data on preventive context inflammation.

Language: Английский

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Comparative analysis of pectin and prebiotics on human microbiota modulation in early life stages and adults

Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 6825 - 6846

Published: Jan. 1, 2024

The gut microbiota is essential in human health, influencing various physiological processes ranging from digestion and metabolism to immune function mental health.

Language: Английский

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