The Role of Nutrition in Chronic Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 664 - 664

Published: Jan. 28, 2023

According to the Centers for Disease Control and Prevention, six out of every ten adults in United States have at least one chronic disease, about four two or more diseases [...]

Language: Английский

---

The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3368 - 3368

Published: July 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Language: Английский

---

Ketogenic nutritional therapy (KeNuT)—a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)—diet therapies in endocrinology and metabolism

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(3), P. 487 - 500

Published: Jan. 18, 2024

Abstract Purpose The ketogenic nutritional therapy (KeNuT) is an effective dietary treatment for patients with obesity and obesity-related comorbidities, including type 2 diabetes, dyslipidaemia, hypertension, coronary artery disease, some of cancers. However, to date official document on the correct prescription diet, validated by authoritative societies in nutrition or endocrine sciences, missing. It important emphasize that requires proper medical supervision patient selection, due complex biochemical implications ketosis need a strict therapeutic compliance, experienced nutritionist personalization whole protocol. Methods This practical guide provides update main clinical indications contraindications meal replacements its mechanisms action. In addition, various phases protocol involving replacements, monitoring, management potential side effects, are also discussed. Conclusion will help healthcare provider acquire necessary skills provide comprehensive care overweight, diseases, using multistep treatment, recognized Club Italian Society Endocrinology (SIE)—Diet Therapies Metabolism.

Language: Английский

---

Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102233 - 102233

Published: Feb. 14, 2024

Language: Английский

---

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Cell Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 13, 2024

Abstract Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which KD exerts its antiepileptic efficacy remain elusive. Herein, we report that KD-produced β-hydroxybutyric acid (BHB) augments brain gamma-aminobutyric (GABA) GABA/glutamate ratio to inhibit epilepsy. The ameliorated pentetrazol-induced mice. Mechanistically, BHB, but not other ketone bodies, inhibited HDAC1/HDAC2, increased H3K27 acetylation, transcriptionally upregulated SIRT4 glutamate decarboxylase 1 ( GAD1 ). BHB-induced de-carbamylated inactivated dehydrogenase preserve for GABA synthesis, upregulation mouse neuron excitation. BHB administration mice induced pentetrazol. BHB-mediated relief of required high level ratio. These results identified as major metabolite suggested may serve an alternative less toxic agent than KD.

Language: Английский

---

A Comprehensive Approach to Parkinson’s Disease: Addressing Its Molecular, Clinical, and Therapeutic Aspects

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7183 - 7183

Published: June 29, 2024

Parkinson's disease (PD) is a gradually worsening neurodegenerative disorder affecting the nervous system, marked by slow progression and varied symptoms. It second most common disease, over six million people in world. Its multifactorial etiology includes environmental, genomic, epigenetic factors. Clinical symptoms consist of non-motor motor symptoms, with being classic presentation. Therapeutic approaches encompass pharmacological, non-pharmacological, surgical interventions. Traditional pharmacological treatment consists administering drugs (MAOIs, DA, levodopa), while emerging evidence explores potential antidiabetic agents for neuroprotection gene therapy attenuating parkinsonian Non-pharmacological treatments, such as exercise, calcium-rich diet, adequate vitamin D supplementation, aim to prevent complications. For those patients who have medically induced side effects and/or refractory surgery therapeutic option. Deep brain stimulation primary option, associated symptom improvement. Levodopa/carbidopa intestinal gel infusion through percutaneous endoscopic gastrojejunostomy portable pump succeeded reducing "off" time, where occur, increasing "on" time. This article aims address general aspects PD provide comparative comprehensive review conventional latest advancements treatments PD. Nevertheless, further studies are required optimize suitable alternatives.

Language: Английский

---

High-fat diet and neuroinflammation: the role of mitochondria

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107615 - 107615

Published: Jan. 1, 2025

Language: Английский

---

Impact of the Ketogenic Diet on Neurological Diseases: A Review

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 71 - 71

Published: Jan. 9, 2025

The ketogenic diet (KD), high in fat and low carbohydrates, was introduced the 1920s as a non-pharmacological treatment for refractory epilepsy. Although its mechanism of action is not fully understood, beneficial effects have been observed neurological diseases such epilepsy, Alzheimer's disease, Parkinson's disease. This review examines impact molecular neuroglial complementary therapy diseases. KD associated with neuroprotective antioxidant that improve mitochondrial function, regulate neurotransmitter flow, reduce neuroinflammation oxidative stress. Glial cells play an essential role utilization ketone bodies (KBs) within central nervous system's metabolism, particularly during ketosis induced by KD. Thus, represents broad promising strategy involves both neurons glial cells, on brain metabolism neuroinflammatory homeostasis. Multiple mechanisms identified to explain benefits diseases; however, further experimental clinical studies are needed address various pathways order achieve conclusive results.

Language: Английский

---

Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 29, 2023

Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, currently approved only provide symptomatic benefits. Emerging epidemiological clinical studies suggest that lifestyle changes, including diet physical activity, offer alternative therapeutic route slowing preventing cognitive decline dementia. Age single most common risk factor dementia, it associated cellular bioenergetics metabolic processes. Therefore, nutrient-rich critical optimal brain health. Furthermore, type 2 diabetes (T2D) AD, diets reduce T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, DASH diets, fruits, leafy green vegetables, fish, nuts, olive oil, prevent or slow decline. The mechanisms by which these nutrients promote health, however, are not yet completely understood. Other dietary approaches eating regimes, ketogenic intermittent fasting, also emerging as beneficial This review summarizes pathophysiology, factors, pathways activated several regimes shown promising results promoting

Language: Английский

---

Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling

JACC Basic to Translational Science, Journal Year: 2023, Volume and Issue: 8(9), P. 1123 - 1137

Published: July 5, 2023

Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact molecular processes underlying this disorder are not fully known. This study includes comprehensive and coordinated set in vivo vitro experiments using human specimens from patients with postischemic heart failure (HF) healthy control subjects, murine model HF, cellular systems. These approaches identified for first time specific pattern maladaptive chromatin remodeling, namely double methylation histone 3 at lysine 27 single 36 (H3_K27me2K36me1) consistently induced by ischemic injury all these settings: HF; models. Mechanistically, work demonstrates that modification mediates ischemia-induced transcriptional repression PPARG coactivator 1α (PGC1α), master regulator mitochondrial function biogenesis. Intriguingly, both augmented H3_K27me2K36me1 dysfunction ensued PGC1α down-regulation were significantly attenuated treatment β-hydroxybutyrate, most abundant ketone body humans, revealing novel pathway coupling metabolism to gene expression. Taken together, findings establish remodeling as key mechanism injury, functionally modulated bodies.

Language: Английский

---