Recent advances in digital microfluidic chips for food safety analysis: Preparation, mechanism and application

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 134, P. 136 - 148

Published: March 11, 2023

Language: Английский

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A Next-Generation Bacteria (Akkermansia muciniphila BAA-835) Presents Probiotic Potential Against Ovalbumin-Induced Food Allergy in Mice

Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 16(3), P. 737 - 751

Published: April 25, 2023

Language: Английский

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Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 12(7), P. 1686 - 1694

Published: April 25, 2024

Language: Английский

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The Etiology of IgE-Mediated Food Allergy: Potential Therapeutics and Challenges

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1563 - 1563

Published: Feb. 13, 2025

Immunoglobulin E (IgE)-mediated food allergy has been dramatically increasing in incidence over the last few decades. The combinations of both genetic and environmental factors that affect microbiome immune system have demonstrated significant roles its pathogenesis. morbidity, at times mortality, occurs as result this specific, reproducible, but impaired response is due to nature shift from a regulatory T (Treg) cellular helper 2 (Th2) response. This imbalance caused by allergens results an interleukin (IL)-4 IL-13 dominant environment drives B cell activation differentiation into IgE-producing plasma cells. resulting symptoms can range mild more severe anaphylaxis, even death. Current therapeutic strategies involve avoidance broad symptom management upon accidental exposure; however, no definitive cure exists. narrative review highlights how elucidation pathogenesis IgE-mediated resulted development therapeutics are specific these individual receptors molecules which relatively successful mitigating potentially life-threatening allergic However, potential adverse effects re-sensitization following conclusion treatment urged need for improved methods. Therefore, given understanding their mechanism action overlap with allergies, probiotics small molecule natural compounds may provide novel preventative strategies. compelling, they success clinical trials hope improve quality life patients.

Language: Английский

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Immunotherapeutic Approaches to Peanut Allergy Treatment—Pre-Clinical and Clinical Studies: A Comprehensive Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1902 - 1902

Published: March 12, 2025

Peanut allergy is a prevalent and potentially life-threatening condition affecting millions of people worldwide, necessitating strict dietary vigilance. Despite its widespread impact, current treatment options are predominantly limited to allergen avoidance emergency management allergic reactions. This review explores contemporary immunotherapeutic strategies aimed at achieving long-term relief for individuals with peanut allergy. We conducted comprehensive literature discuss different approaches, such as subcutaneous immunotherapy (SCIT), epicutaneous (EPIT), oral (OIT), sublingual (SLIT), focusing on their mechanisms, efficacy, safety profiles. Additionally, the delves into novel approaches monoclonal antibodies targeting IgE other critical immune pathways, adjuvanted therapies utilizing nanoparticles gut microbiota, advances in adoptive cell therapy including CAR-T cells regulatory T cells. Furthermore, we highlight some clinical trials that test efficacy these patients Collectively, provide an overview advancements interventions recommendations personalized regimens, ultimately paving way more effective strategies.

Language: Английский

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The Future of Food Allergy Management: Advancements in Therapies

Current Allergy and Asthma Reports, Journal Year: 2024, Volume and Issue: 24(4), P. 161 - 171

Published: Feb. 23, 2024

Language: Английский

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Beyond Antibiotics: What the Future Holds

Antibiotics, Journal Year: 2024, Volume and Issue: 13(10), P. 919 - 919

Published: Sept. 25, 2024

The prevalence of multidrug resistance (MDR) and stagnant drug-development pipelines have led to the rapid rise hard-to-treat antibiotic-resistant bacterial infections. These infectious diseases are no longer just nosocomial but also becoming community-acquired. spread MDR has reached a crisis level that needs immediate attention. landmark O’Neill report projects by 2050, mortality rates associated with infections will surpass individuals afflicted cancer. Since conventional antimicrobials very reliable, it is great importance investigate different strategies combat these life-threatening diseases. Here, we provide an overview recent advances in viable alternative treatment mainly targeting pathogen’s virulence capability rather than viability. Topics include small molecule immune inhibition factors, quorum sensing (QS) quenching, biofilm development, bacteriophage-mediated therapy, manipulation individual’s macroflora

Language: Английский

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The clinical and immunological basis of early food introduction in food allergy prevention

Frontiers in Allergy, Journal Year: 2023, Volume and Issue: 4

Published: Jan. 23, 2023

IgE-mediated food allergy has an estimated prevalence of 6%–10% in developed countries. Allergen avoidance long been the main focus prevention and late solid introduction after 6–12 months age was recommended high-risk infants. However, rising despite delayed exposure to allergens observations that sensitization products could even occur before foods resulted a shift towards early as attempt prevent allergy. Since then, many trials focused on clinical outcome allergen overall seem point protective effect development allergies. For non-IgE-mediated diseases allergy, evidence seems less clear. Moreover, data underlying immunological processes is lacking. The goal this review summarize available changes IgE non-IgE mediated

Language: Английский

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Probiotics as adjuvants to mitigate adverse reactions and enhance effectiveness in Food Allergy Immunotherapy

Scandinavian Journal of Immunology, Journal Year: 2024, Volume and Issue: 100(6)

Published: Oct. 15, 2024

In the past decades, food allergies became increasingly dominant since early childhood, leading to a lower quality of life and increasing costs addressed by health care system. Beside standard avoidance specific allergens drug treatments following allergen exposure, great deal research has lately focused on Food Allergy Allergen Immunotherapy (FA-AIT). SCIT EPIT (Subcutaneous Epicutaneous Immunotherapy), OIT (Oral SLIT (Sublingual Immunotherapy) consist in gradual exposure desensitize achieve tolerance once therapy ended. Although promising, FA-AIT may bring acute local systemic adverse reactions. To enhance efficacy, safety convenience AIT, quest potential adjuvants mitigate reactions becomes crucial. Immunomodulatory activities, such as that regulatory T cells decreasing IgE, have been observed probiotics' strains multiple studies elucidated role gut microbiota major interplayer among host its immune this review, microbiome modulation is shown AIT adjuvant, nevertheless need more clinical near future pivotal assess efficacy targeted bacterial therapies faecal transplantation.

Language: Английский

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The age-specific microbiome of children with milk, egg, and peanut allergy

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(2), P. 203 - 210.e6

Published: April 30, 2024

Language: Английский

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