Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Cell Metabolism, Journal Year: 2019, Volume and Issue: 29(3), P. 592 - 610

Published: March 1, 2019

Language: Английский

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The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2018, Volume and Issue: 17(5), P. 1054 - 1112

Published: July 10, 2018

Abstract Flavonoids are plant‐derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and complex pathways involved bioavailability of flavonoids body now well understood. In recent years, been appreciated that gut microbiome plays major role flavonoid action, but much progress still needs to be made this area. Since first publications health effects flavonoids, their action is understood protect against various stresses, mechanism evolved from debunked simple direct antioxidant hypothesis into an understanding molecular targets enzymes specific cell types. This review traces development field over past 8 decades, indicates current state art, how was reached. Future recommendations based historical analysis (a) focus key areas (b) perform intervention studies focusing protective effects, (c) carry out cellular vitro experiments using appropriate cells together chemical form found at site action; could native compounds food for digestion intestine, conjugated metabolites blood after absorption small intestine cells, or forms tissues catabolism by microbiota.

Language: Английский

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Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review

Obesity Reviews, Journal Year: 2016, Volume and Issue: 17(7), P. 573 - 586

Published: April 15, 2016

Dietary polyphenols constitute a large family of bioactive substances potential beneficial effect on metabolic syndrome (MetS). This review summarizes the results clinical studies patients with MetS involving chronic supplementation polyphenol-rich diet, foods, extracts or single phenolics features (obesity, dyslipidemia, blood pressure and glycaemia) associated complications (oxidative stress inflammation). Polyphenols were shown to be efficient, especially at higher doses, there no specific foods able alleviate all MetS. Green tea, however, significantly reduced body mass index waist circumference improved lipid metabolism. Cocoa glucose. Soy isoflavones, citrus products, hesperidin quercetin metabolism, whereas cinnamon In numerous studies, antioxidative anti-inflammatory effects not significant after polyphenol in However, some trials pointed towards an improvement endothelial function supplemented cocoa, anthocyanin-rich berries, resveratrol. Therefore, diets rich polyphenols, such as Mediterranean which promote consumption diverse products could effective nutritional strategy improve health © 2016 The Authors. Obesity Reviews published by John Wiley & Sons Ltd behalf World Obesity.

Language: Английский

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The safety of green tea and green tea extract consumption in adults – Results of a systematic review

Regulatory Toxicology and Pharmacology, Journal Year: 2018, Volume and Issue: 95, P. 412 - 433

Published: March 24, 2018

A systematic review of published toxicology and human intervention studies was performed to characterize potential hazards associated with consumption green tea its preparations. toxicological evidence from laboratory revealed the liver as target organ hepatotoxicity critical effect, which strongly certain dosing conditions (e.g. bolus dose via gavage, fasting), positively correlated total catechin epigallocatechingallate (EGCG) content. adverse event (AE) data 159 yielded findings consistent in that a limited range concentrated, catechin-rich preparations resulted hepatic AEs dose-dependent manner when ingested large doses, but not consumed brewed or extracts beverages part food. Toxico- pharmacokinetic further suggests internal catechins is key determinant occurrence severity hepatotoxicity. safe intake level 338 mg EGCG/day for adults derived safety solid dose. An Observed Safe Level (OSL) 704 might be considered beverage form based on AE data.

Language: Английский

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Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health

Circulation Research, Journal Year: 2018, Volume and Issue: 122(2), P. 369 - 384

Published: Jan. 18, 2018

A growing body of nutritional science highlights the complex mechanisms and pleiotropic pathways cardiometabolic effects different foods. Among these, some most exciting advances are occurring in area flavonoids, bioactive phytochemicals found plant foods; dairy, including milk, yogurt, cheese. Many relevant ingredients mechanistic now being clarified, shedding new light on both for how diet influences health well-being. Flavonoids, example, have skeletal muscle, adipocytes, liver, pancreas, myocardial, renal, immune cells, instance, related to 5′-monophosphate-activated protein kinase phosphorylation, endothelial NO synthase activation, suppression NF-κB (nuclear factor-κB) TLR4 (toll-like receptor 4). Effects dairy similarly may be mediated by specific amino acids, medium-chain odd-chain saturated fats, unsaturated branched-chain natural trans probiotics, vitamin K1/K2, calcium, as well processing such fermentation homogenization. These characteristics foods influence diverse mammalian target rapamycin, silent information regulator transcript-1, angiotensin-converting enzyme, peroxisome proliferator–activated receptors, osteocalcin, matrix glutamate protein, hepatic de novo lipogenesis, adipose fatty acid oxidation inflammation, gut microbiome interactions intestinal integrity endotoxemia. The complexity these emerging corresponding biological responses rapid continued need generate robust empirical evidence clinical

Language: Английский

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Role of oxidative stress and antioxidants in daily nutrition and human health

Nutrition, Journal Year: 2016, Volume and Issue: 33, P. 311 - 321

Published: Aug. 8, 2016

Language: Английский

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Polyphenol protection and treatment of hypertension

Phytomedicine, Journal Year: 2016, Volume and Issue: 23(2), P. 220 - 231

Published: Jan. 7, 2016

Language: Английский

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Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5246 - 5246

Published: July 6, 2023

Cellular signaling pathways involved in the maintenance of equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited prevention treatment cancer. Epigallocatechin-3-gallate (EGCG) is most abundant phenolic compound found green tea. It has been shown to regulate multiple crucial cellular pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, others. Deregulation abovementioned pathophysiology demonstrated EGCG may exert anti-proliferative, anti-inflammatory, apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical clinical studies suggest used numerous disorders, This review aims summarize existing knowledge regarding biological properties EGCG, especially context cancer prophylaxis.

Language: Английский

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Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1373 - 1373

Published: March 20, 2024

Epigallocatechin gallate (EGCG) is a catechin, which type of flavonoid found in high concentrations green tea. EGCG has been studied extensively for its potential health benefits, particularly cancer. to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects numerous cancer cell lines animal models. demonstrated the ability interrupt various signaling pathways associated with cellular proliferation division different types. anticancer activity mediated by interfering hallmarks. This article summarize highlight on hallmarks focused impacts these cancer-related The studies discussed this review enrich understanding EGCG’s as therapeutic tool against cancer, offering substantial foundation scientists medical experts advance scientific clinical investigations regarding possibility treatment.

Language: Английский

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Flavonoids and Flavonoid-Based Nanoparticles for Osteoarthritis and Rheumatoid Arthritis Management

BioChem, Journal Year: 2024, Volume and Issue: 4(1), P. 38 - 61

Published: March 13, 2024

Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands advanced therapeutic approaches. In this context, flavonoids, diverse group of naturally occurring compounds abundant in fruits, vegetables, medicinal plants, have emerged as promising candidates for mitigating the inflammatory processes associated with arthritic conditions. This review aims, first, to provide comprehensive exploration potential focusing on specific such quercetin, epigallocatechin-3-gallate (EGCG), apigenin, luteolin, fisetin, silibinin, kaempferol, naringenin, myricetin. The second section delves into anti-arthritic activities these drawing insights from clinical trials scientific studies. Each flavonoid is scrutinized individually elucidate its mechanisms action efficacy context both arthritis. third highlights challenges harnessing flavonoids anti-inflammatory purposes. Bioavailability limitations pose significant hurdle, prompting innovative strategies use nanoparticles delivery vehicles. response challenges, fourth focuses emerging field flavonoid-based nanoparticles. includes detailed discussions EGCG, naringenin-based nanoparticles, highlighting formulation preclinical evidence supporting their arthritis management. targeted sites synergistic combinations other are also discussed avenues enhance impact flavonoids. consolidates current knowledge nanoformulations interventions By addressing presenting future research directions, aims contribute advancement effective alleviating

Language: Английский

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