Potential oestrogenic effects (following the OECD test guideline 440) and thyroid dysfunction induced by pure cyanotoxins (microcystin-LR, cylindrospermopsin) in rats DOI Creative Commons
Antonio Casas-Rodríguez, Rosario Moyano, Verónica Molina-Hernández

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 226, P. 115671 - 115671

Published: March 10, 2023

Potential endocrine-disrupting properties of cyanotoxins, such as microcystin-LR (MC-LR) and cylindrospermopsin (CYN) are concern due to their increasing occurrence, the scarcity reports on topic (particularly for CYN) impact human's health at different levels. Thus, this work performed first time uterotrophic bioassay in rats, following Organization Economic Cooperation Development (OECD) Test Guideline 440, explore oestrogenic CYN MC-LR (75, 150, 300 μg/kg b.w./day) ovariectomized (OVX) rats. Results revealed neither changes wet blotted uterus weights nor morphometric study uteri. Moreover, among steroid hormones analysed serum, most remarkable effect was dose-dependent increase progesterone (P) levels rats exposed MC-LR. Additionally, a histopathology thyroids serum were determined. Tissue affectation (follicular hypertrophy, exfoliated epithelium, hyperplasia) observed, well increased T3 T4 both toxins. Taken together, these results point out that not compounds conditions tested assay OVX but, however, thyroid disruption effects cannot be discarded.

Language: Английский

Marine natural products DOI
Anthony R. Carroll, Brent R. Copp, Rohan A. Davis

et al.

Natural Product Reports, Journal Year: 2022, Volume and Issue: 39(6), P. 1122 - 1171

Published: Jan. 1, 2022

A comprehensive review of 1407 new MNPs including turbinmicin, a potent antifungal lead isolated from marine bacterium.

Language: Английский

Citations

216
Mitigation of oxidative stress damage caused by abiotic stress to improve biomass yield of microalgae: A review DOI
Jiangyu Zhu,

Yifei Cai,

Minato Wakisaka

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 896, P. 165200 - 165200

Published: July 1, 2023

Language: Английский

Citations

51
A Review of Common Cyanotoxins and Their Effects on Fish DOI Creative Commons
Halina Falfushynska, Nadiia Kasianchuk, Eduard Siemens

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 118 - 118

Published: Jan. 25, 2023

Global warming and human-induced eutrophication drive the occurrence of various cyanotoxins in aquatic environments. These metabolites reveal diversified mechanisms action, encompassing cyto-, neuro-, hepato-, nephro-, neurotoxicity, pose a threat to biota human health. In present paper, we review data on most studied cyanotoxins, microcystins, nodularins, cylindrospermopsin, anatoxins, saxitoxins, environment, as well their potential bioaccumulation toxicity fish. Microcystins are among all known although other toxic cyanobacterial also commonly identified environments can high Except for primary signs, adversely affect antioxidant system anti-/pro-oxidant balance. Cyanotoxins negatively impact mitochondrial endoplasmic reticulum by increasing intracellular reactive oxygen species. Furthermore, fish exposed microcystins cylindrospermopsin exhibit immunomodulatory, inflammatory, endocrine responses. Even though exert complex pressure fish, numerous aspects yet be subject in-depth investigation. Metabolites than should more thoroughly understand long-term effects provide robust background monitoring management actions.

Language: Английский

Citations

40
Understanding the Risks of Diffusion of Cyanobacteria Toxins in Rivers, Lakes, and Potable Water DOI Creative Commons

Amin Mahmood Thawabteh,

Hani Naseef,

Donia Karaman

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(9), P. 582 - 582

Published: Sept. 20, 2023

Blue-green algae, or cyanobacteria, may be prevalent in our rivers and tap water. These minuscule bacteria can grow swiftly form blooms warm, nutrient-rich Toxins produced by cyanobacteria pollute streams harm the liver nervous system humans. This review highlights properties of 25 toxin types 12 different genera. The also covered strategies for reducing controlling issues. include using physical chemical treatments, cutting back on fertilizer input, algal lawn scrubbers, antagonistic microorganisms biocontrol. Micro-, nano- ultrafiltration techniques could used removal internal extracellular cyanotoxins, addition to powdered granular activated carbon, ozonation, sedimentation, ultraviolet radiation, potassium permanganate, free chlorine, pre-treatment oxidation techniques. efficiency treatment removing intracellular cyanotoxins is demonstrated. approaches aim lessen risks cyanobacterial associated toxins. Effective management water systems depends early detection quick action. Cyanobacteria cells their toxins detected microscopy, molecular methods, chromatography, spectroscopy. Understanding causes many ways elimination will help this crucial environmental issue.

Language: Английский

Citations

26
Four decades of progress in cylindrospermopsin research: The ins and outs of a potent cyanotoxin DOI
Yiming Yang, Gongliang Yu, Youxin Chen

et al.

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 406, P. 124653 - 124653

Published: Nov. 23, 2020

Language: Английский

Citations

67
Cyanotoxins and Food Contamination in Developing Countries: Review of Their Types, Toxicity, Analysis, Occurrence and Mitigation Strategies DOI Creative Commons
Mohamed F. Abdallah, Wannes Hugo R. Van Hassel, Mirjana Andjelković

et al.

Toxins, Journal Year: 2021, Volume and Issue: 13(11), P. 786 - 786

Published: Nov. 6, 2021

Cyanotoxins have gained global public interest due to their potential bioaccumulate in food, which threatens human health. Bloom formation is usually enhanced under Mediterranean, subtropical and tropical climates are the dominant climate types developing countries. In this context, we present an up-to-date overview of cyanotoxins (types, toxic effects, analysis, occurrence, mitigation) with a special focus on contamination (sea)food from all countries Africa, Asia, Latin America as has received less attention. A total 65 publications been found (from 2000 until October 2021) reporting by one or more seafood edible plants (five papers). Only Brazil China conducted research cyanotoxin food comparison other The majority focused detection microcystins using different analytical methods. detected levels mostly surpassed provisional tolerable daily intake limit set World Health Organization, indicating real risk exposed population. Assessment foods still requires further investigations conducting survey studies, especially simultaneous multiple categories food.

Language: Английский

Citations

51
Plant-cyanobacteria interactions: Beneficial and harmful effects of cyanobacterial bioactive compounds on soil-plant systems and subsequent risk to animal and human health DOI
Bahareh Nowruzi,

Noureddine Bouaı̈cha,

James S. Metcalf

et al.

Phytochemistry, Journal Year: 2021, Volume and Issue: 192, P. 112959 - 112959

Published: Oct. 12, 2021

Language: Английский

Citations

50
Co-Occurrence of Taste and Odor Compounds and Cyanotoxins in Cyanobacterial Blooms: Emerging Risks to Human Health? DOI Creative Commons
Maura Manganelli, Emanuela Testai, Zakaria Tazart

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 872 - 872

Published: March 28, 2023

Cyanobacteria commonly form large blooms in waterbodies; they can produce cyanotoxins, with toxic effects on humans and animals, volatile compounds, causing bad tastes odors (T&O) at naturally occurring low concentrations. Notwithstanding the amount of literature either cyanotoxins or T&O, no review has focused them same time. The present critically evaluates recent T&O compounds (geosmin, 2-methylisoborneol, β-ionone β-cyclocitral) to identify research gaps harmful exposure animals both metabolite classes. production be due common different cyanobacterial species/strains, additional possibility by non-cyanobacterial species. few environmental studies co-occurrence these two groups metabolites are not sufficient understand if how co-vary, influence each other, perhaps stimulating cyanotoxin production. Therefore, T&Os cannot reliably serve as early warning surrogates for cyanotoxins. scarce data toxicity seem indicate a health risk (but inhalation β-cyclocitral deserves more study). However, available combined mixtures combinations compounds; therefore, whether is issue remains an open question.

Language: Английский

Citations

19
Cyanotoxins and the Nervous System DOI Creative Commons
James S. Metcalf, Maeve Tischbein, Paul Alan Cox

et al.

Toxins, Journal Year: 2021, Volume and Issue: 13(9), P. 660 - 660

Published: Sept. 16, 2021

Cyanobacteria are capable of producing a wide range bioactive compounds with many considered to be toxins. Although there number toxicological outcomes respect cyanobacterial exposure, this review aims examine those which affect the central nervous system (CNS) or have neurotoxicological properties. Such exposures can acute chronic, and we detail issues concerning CNS entry, detection remediation. Exposure occur through variety media but, increasingly, exposure air via inhalation may greater significance requires further investigation. Even though toxins traditionally been classified based on their primary mode toxicity, increasing evidence suggests that some also possess neurotoxic properties include known cyanotoxins unknown compounds. Furthermore, chronic long-term these is increasingly being identified as adversely affecting human health.

Language: Английский

Citations

35
A review and assessment of cyanobacterial toxins as cardiovascular health hazards DOI Open Access
Zorica Svirčev, Liang Chen,

Kinga Sántha

et al.

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 96(11), P. 2829 - 2863

Published: Aug. 23, 2022

Language: Английский

Citations

26