Unraveling the therapeutic potential of natural products in the prevention and treatment of leukemia

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114351 - 114351

Published: Feb. 1, 2023

Leukemia is a heterogeneous group of hematological malignancies distinguished by differentiation blockage and uncontrolled proliferation myeloid or lymphoid progenitor cells in the bone marrow (BM) peripheral blood (PB). There are various types leukemia which intensive chemotherapy regimens hematopoietic stem cell transplantation (HSCT) now most common treatments associated with severe side effects multi-drug resistance cells. Therefore, it crucial to develop novel therapeutic approaches adequate efficacy selectively eliminate leukemic improve consequences leukemia. Medicinal plants have been utilized for ages treat multiple disorders due their diverse bioactive compounds. Plant-derived products used as medication prevent many cancer. Over last two decades, 50 % all anticancer drugs approved worldwide from natural derivatives. Therefore this study aims review such polyphenols, alkaloids, terpenoids, nitrogen-containing, organosulfur compounds antileukemic agents. Current investigations identified efficiently destroy through mechanisms action inhibiting proliferation, reactive oxygen species production, inducing cycle arrest, apoptosis both vitro, vivo, clinical studies. suitable promising chemotherapeutic chemopreventive It played an essential role drug development emerged possible source biologically active metabolites interventions, especially DATA AVAILABILITY: Data will be made available on request.

Language: Английский

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Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1201 - 1201

Published: April 18, 2024

The complex and multi-stage processes of carcinogenesis are accompanied by a number phenomena related to the potential involvement various chemopreventive factors, which include, among others, compounds natural origin such as flavonols. use flavonols is not only promising but also recognized strategy for cancer treatment. impact on arises from their ability act antioxidants, impede proliferation, promote cell death, inhibit angiogenesis, regulate immune system through in diverse forms cellular death. So far, molecular mechanisms underlying regulation apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis occurring with participation have remained incompletely elucidated, results studies carried out so far ambiguous. For this reason, one therapeutic goals initiate death altered cells quercetin, kaempferol, myricetin, isorhamnetin, galangin, fisetin, morin. This article offers an extensive overview recent research these compounds, focusing particularly role combating elucidating governing cuproptosis. Assessment anticancer effects therapy targeting types pathways may prove useful developing new regimens counteracting resistance previously used treatments.

Language: Английский

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A detailed overview of quercetin: implications for cell death and liver fibrosis mechanisms

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Background Quercetin, a widespread polyphenolic flavonoid, is known for its extensive health benefits and commonly found in the plant kingdom. The natural occurrence extraction methods of quercetin are crucial due to bioactive potential. Purpose This review aims comprehensively cover sources quercetin, methods, bioavailability, pharmacokinetics, role various cell death pathways liver fibrosis. Methods A comprehensive literature search was performed across several electronic databases, including PubMed, Embase, CNKI, Wanfang database, ClinicalTrials.gov, up 10 February 2024. terms employed were “quercetin”, “natural quercetin”, “quercetin methods”, “bioavailability “pharmacokinetics “cell pathways”, “apoptosis”, “autophagy”, “pyroptosis”, “necroptosis”, “ferroptosis”, “cuproptosis”, “liver fibrosis”, “hepatic stellate cells”. These keywords interconnected using AND/OR as necessary. focused on studies that detailed bioavailability pharmacokinetics different pathways, effects Results details quercetin’s involvement apoptosis, autophagy, pyroptosis, necroptosis, ferroptosis, cuproptosis, with particular attention regulatory influence apoptosis autophagy. It dissects mechanisms through which affects these types dosages. Moreover, paper delves into fibrosis, interactions hepatic cells, modulation pertinent signaling cascades. Additionally, it articulates from physical organic chemistry standpoint uniqueness structure potential specific actions liver. Conclusion provides analysis suggesting significant modulating mitigating underscoring therapeutic

Language: Английский

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Crosstalk between autophagy and metabolism: implications for cell survival in acute myeloid leukemia

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 24, 2024

Abstract Acute myeloid leukemia (AML), a prevalent form of in adults, is often characterized by low response rates to chemotherapy, high recurrence rates, and unfavorable prognosis. A critical barrier managing refractory or recurrent AML the resistance chemotherapy. Increasing evidence indicates that tumor cell metabolism plays crucial role progression, survival, metastasis, treatment resistance. Autophagy, an essential regulator cellular energy metabolism, increasingly recognized for its metabolic reprogramming AML. Autophagy sustains cells during chemotherapy not only providing but also facilitating rapid proliferation through supply components such as amino acids nucleotides. Conversely, state can influence activity autophagy. Their mutual coordination helps maintain intrinsic homeostasis, which significant contributor cells. This review explores recent advancements understanding interaction between autophagy cells, emphasizing their roles survival drug comprehensive interplay shed light on strategies, particularly under adverse conditions insight may pave way innovative targeted strategies.

Language: Английский

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Anticancer and apoptosis inducing potential of quercetin against a wide range of human malignancies

International Journal of Food Properties, Journal Year: 2023, Volume and Issue: 26(1), P. 2590 - 2626

Published: Sept. 7, 2023

Quercetin, a flavonoid, is dietary component that has attracted the attention of dietitians and medicinal chemists due to its anticancer potential. It an antioxidant significant role in reducing different human cancers such as breast, pancreatic, prostate, colon, blood, oral. Being additional anti-cancer agent, it can stop cancer cell invasion metastasis, induce apoptosis autophagy, decrease growth proliferation. Multiple mechanisms, including suppression pathways involved survival, angiogenesis, inflammation, are thought be responsible for these effects. Quercetin anti-inflammatory properties both vitro vivo tests, which important chronic inflammation major contributor cancer. Preventing synthesis cytokines chemokines encourage support lessen spread In cells, quercetin cause programmed death, cells from rapidly multiplying replicating. provides protection against degradation DNA induced by radiation other carcinogens. The PI3K/Akt/mTOR pathway, NF-κB system, Wnt/β-catenin pathway few signaling modulates. activate process breaks range having terminate recover damaged or unwanted cellular mechanisms. best treatment plans various kinds will need determined through research, also help confirm safety effectiveness humans.

Language: Английский

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Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 396(12), P. 3443 - 3458

Published: July 25, 2023

Language: Английский

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A global bibliometric and visualized analysis of the links between the autophagy and acute myeloid leukemia

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 23, 2024

Background and objectives: Autophagy is a cellular process where damaged organelles or unwanted proteins are packaged into double-membrane structure transported to lysosomes for degradation. plays regulatory role in various hematologic malignancies, including acute myeloid leukemia (AML). However, there few bibliometric studies on the of autophagy AML. The purpose this study clarify through analysis. Methods: literature AML research from 2003 2023 was searched Web Science Core Collection, tools such as VOSviewer 1.6.18, Cite Space (6.1.R3), RStudio (R package bibliometrix), Scimago Graphica were used understand current status hotspots research. conducted an analysis dimensions quantity publications, countries, institutions, journals, authors, co-references, keywords, predict future development trends field by drawing relevant visualization maps. Results: A total 343 articles obtained, published 169 written 2,323 authors 295 institutions 43 countries. journals with most publications Blood Oncotarget. China had Chongqing Medical University Sun Yat-sen publications. author highest number Tschan, Mario P. main types included clinical research, vitro experiments, vivo public database information, reviews, forms therapeutic effects mainly focused genetic regulation, traditional Chinese medicine combination, inhibitors, drug targets. past 17 years have inhibition, targeted drugs. Chemotherapy resistance mitochondrial will be forefront Conclusion: gradual increase decline after 2022 could result focusing more type quality literature. autophagy-related In future, remain focus field, likely chemotherapy autophagy.

Language: Английский

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Inflammasomes Are Influenced by Epigenetic and Autophagy Mechanisms in Colorectal Cancer Signaling

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6167 - 6167

Published: June 3, 2024

Inflammasomes contribute to colorectal cancer signaling by primarily inducing inflammation in the surrounding tumor microenvironment. Its role is receiving increasing attention, as has a protumor effect addition tissue damage. The inflammasome's function complex and controlled several layers of regulation. Epigenetic processes impact functioning or manifestation genes that are involved control inflammasomes subsequent cascades. Researchers have intensively studied significance epigenetic mechanisms regulation, they encompass potential therapeutic targets. regulatory interactions between inflammasome autophagy intricate, exhibiting both advantageous harmful consequences. aspects two entities also relationship activation inflammasome, autophagy, alterations CRC involves interrelated pathways. This article provides brief summary newest studies on how epigenetics with special focus their cancer. Based latest findings, we provide an overview ideas for this network.

Language: Английский

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Enhancing impact of dietary nano formulated quercetin on laying performance: egg quality, oxidative stability of stored eggs, intestinal immune and antioxidants related genes expression

BMC Veterinary Research, Journal Year: 2024, Volume and Issue: 20(1)

Published: Oct. 29, 2024

Nutritional interventions with natural antioxidants can provide a pragmatic solution for modifying hens' performance and maintaining oxidative stability of eggs during storage. Quercetin is the most abundant flavonoids potent antioxidant immune stimulant activities. The concept incorporating quercetin, as immunostimulant, into effective nano-carriers (QNPs) has promoted their bioavailability thus, effectiveness first time were assessed on laying immunity, quality Four hundred 12-weeks-old Hy-line brown hens distributed to four experimental groups: control group fed basal diets, other 3 groups diets fortified 100, 200 300 mg/kg QNPs 60 weeks. Laying laid improved expressed by elevated rate, egg mass %, weight yolk in QNPs200 300. Fortification QNPs300 remarkably decreased layers serum total cholesterol concurrently saturated fatty acids while increased polyunsaturated acids. Over- 45 days storage period, enhanced phospholipids, phenolics flavonoids, activity (T-AOC) simultaneous MDA content eggs. Furthermore, response was detected both intestine reflected higher lysozymes activity, IgM, IgG phagocytic index demotion NO together AvBD 6–12, IL-10, IgM ATg 5-7-12 upregulation downregulation IL-1β TNF-α especially at Intestinal redox balance modified via decreasing H2O2 catalase, SOD, GSH-Px, HO-1 NQO1 doses QNPs. supplementation provides new nutritional strategy towards increasing hen performance, fortification that prevents deterioration

Language: Английский

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Amplification of Cardioprotective Response of Remote Ischemic Preconditioning in Rats by Quercetin: Potential Role of Activation of mTOR-dependent Autophagy and Nrf2

Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Language: Английский

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