Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats DOI Creative Commons
Keerthi Thirtamara Rajamani, Marie Barbier, Arthur Lefèvre

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(2), P. 412 - 424

Published: Dec. 5, 2023

Abstract Oxytocin plays an important role in modulating social recognition memory. However, the direct implication of oxytocin neurons paraventricular nucleus hypothalamus (PVH) and their downstream hypothalamic targets regulating short- long-term forms memory has not been fully investigated. In this study, we employed a chemogenetic approach to target activity PVH male rats found that specific silencing neuronal population led impairment We combined viral-mediated fluorescent labeling with immunohistochemical techniques identified supramammillary (SuM) as oxytocinergic axonal projections rats. used multiplex fluorescence situ hybridization label receptors SuM determined they are predominantly expressed glutamatergic neurons, including those project CA2 region hippocampus. Finally, highly selective receptor antagonist examine involvement signaling it is necessary for formation both. This study discovered previously undescribed via reinforced form

Language: Английский

BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking DOI Creative Commons
Christopher Gabriel, Zachary Zeidler, Benita Jin

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Aug. 18, 2022

Quantitative descriptions of animal behavior are essential to study the neural substrates cognitive and emotional processes. Analyses naturalistic behaviors often performed by hand or with expensive, inflexible commercial software. Recently, machine learning methods for markerless pose estimation enabled automated tracking freely moving animals, including in labs limited coding expertise. However, classifying specific based on data requires additional computational analyses remains a significant challenge many groups. We developed BehaviorDEPOT (DEcoding POsitional Tracking), simple, flexible software program that can detect from video timeseries analyze results experimental assays. calculates kinematic postural statistics keypoint creates heuristics reliably behaviors. It no programming experience is applicable wide range designs. provide several hard-coded heuristics. Our freezing detection heuristic achieves above 90% accuracy videos mice rats, those wearing tethered head-mounts. also helps researchers develop their own incorporate them into software’s graphical interface. Behavioral stored framewise easy alignment data. demonstrate immediate utility flexibility using popular assays fear conditioning, decision-making T-maze, open field, elevated plus maze, novel object exploration.

Language: Английский

Citations

41
REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation DOI Creative Commons
Han Qin, Ling Fu,

Tingliang Jian

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(23), P. 4000 - 4014.e6

Published: Oct. 21, 2022

Language: Английский

Citations

39
Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice DOI Creative Commons
Noelia S. de León-Reyes, Paula Sierra Díaz, Ramon Nogueira

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(19), P. 4152 - 4171.e31

Published: Sept. 1, 2023

Language: Английский

Citations

35
The role of the prefrontal cortex in social interactions of animal models and the implications for autism spectrum disorder DOI Creative Commons
Alok Nath Mohapatra, Shlomo Wagner

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: June 20, 2023

Social interaction is a complex behavior which requires the individual to integrate various internal processes, such as social motivation, recognition, salience, reward, and emotional state, well external cues informing of others' behavior, state rank. This phenotype susceptible disruption in humans affected by neurodevelopmental psychiatric disorders, including autism spectrum disorder (ASD). Multiple pieces convergent evidence collected from studies rodents suggest that prefrontal cortex (PFC) plays pivotal role interactions, serving hub for affiliation, empathy, hierarchy. Indeed, PFC circuitry results deficits symptomatic ASD. Here, we review this describe ethologically relevant tasks could be employed with rodent models study interactions. We also discuss linking pathologies associated Finally, address specific questions regarding mechanisms may result atypical interactions models, future should address.

Language: Английский

Citations

31
Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit DOI Creative Commons

Su‐Su Lv,

Xue‐Jing Lv,

Yaqi Cai

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(3)

Published: Jan. 19, 2024

Anxiety and depression are frequently observed in patients suffering from trigeminal neuralgia (TN), but neural circuits mechanisms underlying this association poorly understood. Here, we identified a dedicated circuit the ventral hippocampus (vHPC) to medial prefrontal cortex (mPFC) that mediates TN-related anxiodepression. We found TN caused an increase excitatory synaptic transmission vHPC CaMK2A neurons mPFC inhibitory marked by expression of corticotropin-releasing hormone (CRH). Activation CRH + subsequently led feed-forward inhibition layer V pyramidal via activation receptor 1 (CRHR1). Inhibition -mPFC ameliorated TN-induced anxiodepression, whereas activating pathway sufficiently produced anxiodepressive-like behaviors. Thus, our studies driving pain-related anxiodepression molecular target for treating psychiatric disorders.

Language: Английский

Citations

12
Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies DOI
Nancy R. Mack,

Nadia N. Bouras,

Wen‐Jun Gao

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(2), P. 85 - 94

Published: March 13, 2024

Language: Английский

Citations

9
A Subpopulation of Prefrontal Cortical Neurons Is Required for Social Memory DOI
Bo Xing, Nancy R. Mack, Kaiming Guo

et al.

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 89(5), P. 521 - 531

Published: Sept. 6, 2020

Language: Английский

Citations

64
Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex DOI
Bin Yu, Bo Yuan, Jiankun Dai

et al.

Neuroscience Bulletin, Journal Year: 2020, Volume and Issue: 36(6), P. 570 - 584

Published: March 7, 2020

Language: Английский

Citations

51
Skipping ahead: A circuit for representing the past, present, and future DOI Creative Commons
Jennifer C. Robinson, Mark P. Brandon

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 14, 2021

Envisioning the future is intuitively linked to our ability remember past. Within memory system, substantial work has demonstrated involvement of prefrontal cortex and hippocampus in representing past present. Recent data shows that both encode trajectories, which are segregated time by alternating cycles theta rhythm. Here, we discuss how information temporally organized these brain regions supported medial septum, nucleus reuniens, parahippocampal regions. Finally, highlight a circuit predict essential for temporal segregation scenarios.

Language: Английский

Citations

44
Dynamic influences on the neural encoding of social valence DOI
Nancy Padilla-Coreano, Kay M. Tye, Moriel Zelikowsky

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(9), P. 535 - 550

Published: July 12, 2022

Language: Английский

Citations

38