Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

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A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: March 10, 2023

Abstract As a less O 2 ‐dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia‐induced low efficiency against solid tumors. However, commonly used metal‐involved agents suffer from long‐term biosafety concern. Herein, metal‐free photosensitizer, N ‐doped carbon dots/mesoporous silica nanoparticles (NCDs/MSN, ≈40 nm) nanohybrid with peroxidase (POD)‐like activity for synergistic and enzyme‐activity treatment, developed on gram scale via facile one‐pot strategy through mixing source precursor assistance of template. Benefiting narrow bandgap (1.92 eV) good charge separation capacity NCDs/MSN, upon 640 nm light irradiation, excited electrons in conduction band can effectively generate •− by reduction dissolved one‐electron transfer process even under hypoxic conditions, inducing apoptosis tumor cells. Moreover, photoinduced partially transform into more toxic • OH two‐electron reduction. POD‐like NCDs/MSN catalyze endogenous H microenvironment, further synergistically ablating 4T1 Therefore, mass production way synthesize novel photosensitizer enzyme‐mimic treatment tumors provided, which exhibits promising clinical translation prospects.

Language: Английский

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Neutrophil-like Biomimic AIE Nanoparticles with High-Efficiency Inflammatory Cytokine Targeting Enable Precise Photothermal Therapy and Alleviation of Inflammation

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7394 - 7405

Published: April 3, 2023

Although photothermal therapy (PTT) has thrived as a promising treatment for drug-resistant bacterial infections by avoiding the abuse of antibiotics, remaining challenges that limit efficiency are poor targeting properties infected lesions and low penetration to cell membrane Gram-negative bacteria. Herein, we developed biomimetic neutrophil-like aggregation-induced emission (AIE) nanorobot (CM@AIE NPs) precise inflammatory site homing efficient PTT effects. Due their surface-loaded neutrophil membranes, CM@AIE NPs can mimic source thus interact with immunomodulatory molecules would otherwise target endogenous neutrophils. Coupled secondary near-infrared region absorption excellent AIE luminogens (AIEgens), localization, in sites be achieved, thereby minimizing damage surrounding normal tissues. Moreover, NP-mediated was stimulated vivo 980 nm laser irradiation, which contributed extent therapeutic depth limited skin The good biocompatibility vitro antibacterial effects prove provide strategy broad-spectrum applications.

Language: Английский

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Constructing Oxygen‐Related Defects in Carbon Nanodots with Janus Optical Properties: Noninvasive NIR Fluorescent Imaging and Effective Photocatalytic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(35)

Published: May 22, 2023

Noninvasive fluorescence (FL) imaging and high-performance photocatalytic therapy (PCT) are opposing optical properties that difficult to combine in a single material system. Herein, facile approach introducing oxygen-related defects carbon dots (CDs) via post-oxidation with 2-iodoxybenzoic acid is reported, which some nitrogen atoms substituted by oxygen atoms. Unpaired electrons these rearrange the electronic structure of oxidized CDs (ox-CDs), resulting an emerging near-infrared (NIR) absorption band. These not only contribute enhanced NIR bandgap emission but also act as trappers for photoexcited promote efficient charge separation on surface, leading abundant photo-generated holes ox-CDs surface under visible-light irradiation. Under white LED torch irradiation, oxidize hydroxide hydroxyl radicals acidification aqueous solution. In contrast, no detected solution 730 nm laser indicating noninvasive FL potential. Utilizing Janus ox-CDs, vivo sentinel lymph nodes around tumors photothermal tumor PCT demonstrated.

Language: Английский

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Functionalized heteroatom-doped carbon dots for biomedical applications: A review

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1284, P. 341874 - 341874

Published: Oct. 9, 2023

Carbon nanoparticles (CDs) have recently drawn a great attention in (bio)chemical analysis, sensing and bioimaging owing to their photostability, water stability, minimal toxicity, biocompatibility ease of surface functionalization. While the vast majority CDs applications rely on exploiting fluorescent properties, doping such nanomaterials with various elements has received increasing as an effective approach modify optoelectronic characteristics, introducing novel improved optical features phosphorescence, upconversion luminescence or multimodal imaging capabilities. This review article focuses recent advances synthesis heteroatom-doped CDs, exhibiting distinctive high value for imaging, well functionalization schemes developed guided analyte labeling. Relevant chemical sensing, disease therapy are here presented. A final section intends provide overview towards future developments emerging light-emitting design devices strategies (bio)analytical chemistry.

Language: Английский

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Carbon‐Dot‐Mediated Highly Efficient Visible‐Driven Photocatalytic Hydrogen Evolution Coupled with Organic Oxidation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(51)

Published: Aug. 29, 2023

Abstract Photocatalytic hydrogen evolution coupled with organic oxidation reaction is a promising alternative to water splitting, where the efficiency limited due weak correlation between charge separation and surface redox reactions. Here, employing nickel phthalocyanine (NiPc) for hole extraction, NiPc‐modified carbon dots (CDs) are combined Cu–In–Zn–S quantum (CIZS QDs) toward profound understanding of electron/hole extraction proton generation reduction. The optimal rate reaches 4.10 mmol g −1 h CIZS/NiPc–CDs l ‐ascorbic acid consumption, 8.10 times that CIZS QDs, which further promoted 11.12 under coextraction Ni 2+ introduction. For benzyl‐alcohol‐oxidation‐coupled H 2 evolution, this strategy shows more dramatic activity enhancement (19.54 times), also appliable methanol‐ or furfuryl‐alcohol‐oxidation coupling systems state‐of‐the‐art activities. Transient photovoltage spectroscopy apparent kinetics analysis indicate, first time, light‐induced electrocatalysis effect consistent Volmer–Heyrovsky process, establishes quasiquantitative basis balancing

Language: Английский

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Advances on carbon nanomaterials and their applications in medical diagnosis and drug delivery

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114032 - 114032

Published: June 13, 2024

Language: Английский

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Combination of Efficient Red Fluorescence and High Photothermal Conversion in the Second Near‐Infrared Window from Carbon Dots through Photoinduced Sodium‐Doping Approach

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 12, 2024

Abstract Carbon dots (CDs) are highly desired in biological applications. However, achieving a balance between photoluminescence (PL) efficiency and photothermal conversion (PTCE) is challenging. In this study, an unprecedent combination of efficient red fluorescence high PTCE the second near‐infrared (NIR‐II) window sodium‐doped CDs system reported. Upon 808 nm laser irradiation, photo‐induced oxidation–reduction reactions happened on surface sodium cation‐functionalized (Na‐CDs), leading to partial reduction surface‐functionalized (Na) ions. The photo‐reduced Na atoms coordinated with sp 2 C domains core, resulting Na‐doped (ir‐Na‐CDs) enhanced absorption band NIR‐II 43% under 1064 irradiation (1 W cm −2 ). Composing ir‐Na‐CDs bovine serum albumin (BSA) PLQY emission 31% water without diminishing region. Transient spectra revealed that no energy transfer occurred center band, revealing novel independent Janus photophysical processes. Moreover, ir‐Na‐CDs@BSA exhibited negligible low cytotoxicity demonstrated tumor accumulation capacity after intravenous injection, enabling effective therapy

Language: Английский

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2024 roadmap on membrane desalination technology at the water-energy nexus

Journal of Physics Energy, Journal Year: 2024, Volume and Issue: 6(2), P. 021502 - 021502

Published: Feb. 26, 2024

Abstract Water and energy are two strategic drivers of sustainable development, intimately interlaced vital for a secure future humanity. Given that water resources limited, whereas global population demand exponentially growing, the competitive balance between these resources, referred to as water-energy nexus, is receiving renewed focus. The desalination industry alleviates stress by producing freshwater from saline sources, such seawater, brackish or groundwater. Since last decade, market has been dominated membrane technology, offering significant advantages over thermal processes, lower demand, easy process control scale-up, modularity flexible productivity, feasibility synergic integration different operations. Although seawater reverse osmosis (SWRO) accounts more than 70% capacity, it circumscribed some technological limitations, as: (i) relatively low recovery factor (around 50%) due negative impact osmotic polarization phenomena; (ii) an consumption in range 3–5 kWh m −3 , still far theoretical (1.1 ) produce potable (at 50% factor). Ultimately, intensive practice research efforts oriented toward development alternative energy-efficient approaches order enhance without placing excessive strain on limited supplies. Recent years have seen relevant surge interest distillation (MD), thermally driven technology having potential complement SWRO logic Process Intensification Zero Liquid Discharge paradigm. Due its peculiar transport mechanism negligibility phenomena, MD allows high-quality distillate production (theoretically, non-volatile species completely rejected) with up 80% at operative temperature (typically 60 °C–80 °C). temperatures make attractive renewable power applications (e.g. solar thermal, wind geothermal sources) efficient exploitation low-grade waste heat streams, efficiency intrinsically losses—and specifically polarization—has so hindered application industrial scale. Nowadays, photothermal materials able absorb convert natural artificial irradiation into gained great attention, demonstrating mitigate ‘anthropic’ input inefficiencies. On this road, step-change improvement light-to-heat conversion expected through high-throughput computational screening thermoplasmonic based electronic optical properties advanced including novel topological phases matter used nanofillers polymeric membranes. Coherently concept Circular Economy, hypersaline solutions rejected (referred ‘brine’) now subject valorization activities along main routes: (1) valuable minor trace metals minerals, special focus critical raw (including, among others, Mg, Na, Ca, K, Sr, Li, Br, B, Rb); (2) salinity gradient (SGP) resulting Gibbs mixing (mainly represented entropic contribution) ionic concentration. exciting new frontier mining concentrates accelerating appearance plethora innovative methods brine dehydration selective extraction ions, although under sword Damocles cost reliable commercial application. other hand, several emerging technologies, electrodialysis (SGP-RED) was already proven capable—at least kW scale–of turning chemical difference river water, electrical energy. Efforts develop next generation ion exchange membranes exhibiting high perm-selectivity (especially monovalent ions) resistance, improve system engineering optimize operational conditions, pursue goal enhancing density achievable (in few W per 2 ). This Roadmap takes form series short contributions written independently worldwide experts topic. Collectively, provide comprehensive picture current state art science how future. In addition, acknowledges challenges advances systems, particularly emphasizing interplay material innovation optimization, which collectively contribute advancing field within nexus framework.

Language: Английский

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Samarium doped carbon dots for near-infrared photo-therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150661 - 150661

Published: March 24, 2024

Language: Английский

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